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¿Clasificar o castigar?: Un estudio sobre el rol de los profesionales en el Servicio Penitenciario Bonaerense

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Autores/as: María Julia Di Carlo ; Esteban Rodriguez Alzueta ; Iván Galvani ; Hernán Olaeta ; Rodolfo Luis Brardinelli

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Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2016 Repositorio Institucional Digital de Acceso Abierto de la Universidad Nacional de Quilmes (SNRD) acceso abierto

Cobertura temática: Medicina básica - Sociología - Derecho - Filosofía, ética y religión  

Di Carlo, M. J. (2016) ¿Clasificar o castigar? Un estudio sobre el rol de los profesionales en el Servicio Penitenciario Bonaerense. (Tesis de maestría). Universidad Nacional de Quilmes, Bernal, Argentina.

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¿Es el pico flujo ambulatorio representativo de la función respiratoria y equivalente a la espirometría por software?

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Autores/as: Pablo José María Vilela

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Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2009 SEDICI: Repositorio Institucional de la UNLP (SNRD) acceso abierto

Cobertura temática: Medicina básica  

Las diferentes técnicas de exploración de la función pulmonar aportan información, a menudo esencial, para el diagnóstico y evaluación del grado de disfunción pulmonar. Existe un conjunto de pruebas básicas que se emplean de forma convencional en la clínica para establecer el perfil de la función pulmonar en el paciente objeto de estudio. Entre ellas se encuentra la espirometría forzada con prueba broncodilatadora. Un método rápido, económico y de fácil realización para evaluar a un enfermo con alteraciones respiratorias, es la realización del pico flujo con un neumotacómetro (Pick-Flow). El mismo mide el volumen espirado durante el primer segundo de la maniobra. Este método que es rápido, de bajo costo y fácil de transportar en cualquier maletín médico, es una prueba básica que debe estar al alcance del médico general para la valoración correcta del paciente.

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"One rotten apple spoils the whole barrel": The plant hormone ethylene, the small molecule and its complexity

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ISBNs: 9782889196234 (impreso)

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Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2015 Directory of Open access Books acceso abierto

Cobertura temática: Ciencias biológicas - Medicina básica - Otras ciencias sociales  

The gaseous molecule ethylene (C2H4), which is small in size and simple in structure, is a plant hormone most often associated with fruit ripening yet has a diversity of effects throughout the plant life cycle. While its agricultural effects were known even in ancient Egypt, the complexity of its mode of action and the broad spectrum of its effects and potential uses in plant physiology remain important scientific challenges today. In the last few decades, the biochemical pathway of ethylene production has been uncovered, ethylene perception and signaling have been molecularly dissected, ethylene-responsive transcription factors have been identified and numerous effects of ethylene have been described, ranging from water stress, development, senescence, reproduction plant-pathogen interactions, and of course, ripening. Thus ethylene is involved in plant development, in biotic and abiotic stress, and in reproduction. There is no stage in plant life that is not affected by ethylene, modulated by a complex and fascinating molecular machinery.

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2014: what new directions for Alzheimer's disease?

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ISBNs: 9782889195350 (impreso)

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No requiere 2015 Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica - Ciencias de la salud - Otras ciencias sociales  

According to the World Health Organization, more than 40 million people in the world are affected with dementia. To date, 60-70% of the cases of dementia are attributed to the Alzheimer's disease (AD). This neurodegenerative disorder gradually takes place over a period of at least 20 years before the onset of symptoms, which are impaired memory, apathy and depression. The characteristics of AD consist in neurofibrillary tangles (intraneuronal aggregates of hyperphosphorylated tau proteins) and senile plaques (dense extraneuronal deposits composed of amyloid ß (Aß)). The other features linked to these two core pathological hallmarks of AD are inflammation, oxidative stress, progressive synaptic and neuronal loss. In past years, some of the emerging therapeutic strategies against AD were employed to deal with the pathological hallmarks of the disease. Science teams all over the world try to restore the tau phosphorylation equilibrium. Their purpose is to interfere with the aggregation of tau and decrease its amount of proteins per se as well. Furthermore, they are trying either to stimulate the elimination processes of the aggregated tau proteins or to stop the formation of Aß peptides. This could be reached by the stimulation of the classic techniques of protein degradation such as the autophagic pathway, or by the targeted immunotherapy. In this Research Topic, we wish to summarize and review the etiology of AD and the related therapeutic opportunities for the next decades. To fully understand the precise mechanisms underlying AD, research findings, reviews, new insights and new approaches include AD and related tauopathies, tau phosphorylation balance, pharmacological compounds against AD, neuroprotection strategies and new therapeutic ways but also risk factors for AD and AD genetic information are included in this issue.

25 Years of p53 Research

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ISBNs: 978-1-4020-2920-2 (impreso) 978-1-4020-2922-6 (en línea)

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No detectada 2005 SpringerLink

Cobertura temática: Ciencias biológicas - Medicina básica - Medicina clínica  


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30 years of the Comet Assay: an overview with some new insights

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ISBNs: 9782889196494 (impreso)

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No requiere 2015 Directory of Open access Books acceso abierto

Cobertura temática: Ciencias biológicas - Medicina básica - Medicina clínica - Ciencias de la salud - Otras ciencias sociales  

By means of this ‘Frontiers in Genetics’ research topic, we are celebrating 30 years of the Comet Assay. The first paper on this single-cell gel electrophoresis assay was published in 1984 by O. Ostling and K.J. Johanson (Biochem. Biophys. Res. Commun. Vol.123: 291-298). The comet assay is a versatile and sensitive method for measuring single - and double-strand breaks in DNA. By including lesion-specific enzymes in the assay, its range and sensitivity are greatly increased, but it is important to bear in mind that their specificity is not absolute. The comet assay (with and without inclusion of lesion-specific enzymes) is widely used as a biomarker assay in human population studies - primarily to measure DNA damage, but increasingly also to assess the capacity of cells for DNA repair. Ostling and Johanson (Biochem. Biophys. Res. Commun., 1984) were also the first to report experiments to measure DNA repair, by simply following the decrease of DNA damage over time after challenging cells with ionising radiation. However, this approach is time-consuming and laborious as it requires an extended period of cell culture and is therefore not ideal for biomonitoring studies, which typically require high-throughput processing of many samples. As an alternative approach, the in vitro comet-based repair assay was developed: a cell extract is incubated with a DNA substrate containing specific lesions, and DNA incisions accumulate. The in vitro comet-based repair assay has been modified and improved over the past decade: it was first devised to measure base excision repair of oxidised purines in lymphocytes (Collins et al., Mutagenesis, 2001), but has since been adapted for other lesions and thus other repair pathways, as well as being applied to tissue samples in addition to cell suspensions. Even after 30 years, the comet assay is still in a growth phase, with many new users each year. Many questions are repeatedly raised, which may seem to have self-evident answers, but clearly, it is necessary to reiterate them for the benefit of the new audience, and sometimes being forced to think again about old topics can shed new light. Different applications of the comet assay are discussed in this special issue, including: genotoxicity testing in different organisms, human biomonitoring, DNA repair studies, environmental biomonitoring and clinical studies. Furthermore, we consider and where possible answer questions, including the ones raised by Raymond Tice at the 8th International Comet Assay Workshop in Perugia (Italy 2009): What is the spectrum of DNA damage detected by the various versions of the comet assay?; What are the limitations associated with each application?; What should be done to standardize the assay for biomonitoring studies?; Can the comet assay be used to monitor changes in global methylation status?; What cell types are suitable for detecting genotoxic substances and their effects in vivo and in vitro?; Can the assay be fully automated?; and more. So this ‘Frontiers in Genetics’ research topic is written for the beginner as well as for the experienced users of the comet assay.

35th Hemophilia Symposium: Hamburg 2004

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ISBNs: 978-3-540-28543-4 (impreso) 978-3-540-28546-5 (en línea)

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No detectada 2006 SpringerLink

Cobertura temática: Medicina básica - Medicina clínica  


3D Radiative Transfer in Cloudy Atmospheres

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ISBNs: 978-3-540-23958-1 (impreso) 978-3-540-28519-9 (en línea)

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No detectada 2005 SpringerLink

Cobertura temática: Ciencias de la tierra y ciencias ambientales relacionadas - Ciencias biológicas - Ingeniería médica - Medicina básica  


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AAPS Open

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ISSNs 2364-9534 (en línea)

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Institución detectada Período Navegá Descargá Solicitá
No requiere desde oct. 2022 / hasta oct. 2022 Directory of Open Access Journals acceso abierto
No requiere desde nov. 2015 / hasta oct. 2022 SpringerLink acceso abierto

Cobertura temática: Medicina básica  


AAPS PharmSciTech

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ISSNs 1530-9932 (en línea)

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Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 2019 / hasta dic. 2020 SpringerLink

Cobertura temática: Medicina básica