Catálogo de publicaciones

Compartir en
redes sociales


Navegación

Tipo

Acceso

Plataformas

Temática

Mostrando 10 de 3.863 registro(s)

Filtros temática quitar todos

libros Acceso Abierto
Agregar a Mi catálogo

"Behinderung" im Dialog zwischen Recht und Humangenetik

Más información

ISBNs: 9783863951504 (impreso)

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2014 Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica  

Modern medical technologies, especially the pre-implantation and prenatal diagnosis, have given the possibility of preventive dealing with the risks of physical or mental disabilities. On the other side there is the call for support and “inclusion” of people with disabilities. These opposing trends are critically analyzed and discussed in depth from a legally, genetic, as well as from a medical, social and ethical point of view.

libros Acceso Abierto
Agregar a Mi catálogo

10 Years of Ethnopharmacology

Más información

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica  


libros Acceso Abierto
Agregar a Mi catálogo

10 Years of Inflammation Pharmacology

Más información

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica  


libros Acceso Abierto
Agregar a Mi catálogo

10 Years of Neuropharmacology

Más información

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica  


libros Acceso Abierto
Agregar a Mi catálogo

10th Anniversary of Applied Sciences-Invited Papers in Chemistry Section

Más información

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica - Medicina clínica  


libros Acceso Abierto
Agregar a Mi catálogo

2014: what new directions for Alzheimer's disease?

Más información

ISBNs: 9782889195350 (impreso)

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2015 Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica - Ciencias de la salud - Otras ciencias sociales  

According to the World Health Organization, more than 40 million people in the world are affected with dementia. To date, 60-70% of the cases of dementia are attributed to the Alzheimer's disease (AD). This neurodegenerative disorder gradually takes place over a period of at least 20 years before the onset of symptoms, which are impaired memory, apathy and depression. The characteristics of AD consist in neurofibrillary tangles (intraneuronal aggregates of hyperphosphorylated tau proteins) and senile plaques (dense extraneuronal deposits composed of amyloid ß (Aß)). The other features linked to these two core pathological hallmarks of AD are inflammation, oxidative stress, progressive synaptic and neuronal loss. In past years, some of the emerging therapeutic strategies against AD were employed to deal with the pathological hallmarks of the disease. Science teams all over the world try to restore the tau phosphorylation equilibrium. Their purpose is to interfere with the aggregation of tau and decrease its amount of proteins per se as well. Furthermore, they are trying either to stimulate the elimination processes of the aggregated tau proteins or to stop the formation of Aß peptides. This could be reached by the stimulation of the classic techniques of protein degradation such as the autophagic pathway, or by the targeted immunotherapy. In this Research Topic, we wish to summarize and review the etiology of AD and the related therapeutic opportunities for the next decades. To fully understand the precise mechanisms underlying AD, research findings, reviews, new insights and new approaches include AD and related tauopathies, tau phosphorylation balance, pharmacological compounds against AD, neuroprotection strategies and new therapeutic ways but also risk factors for AD and AD genetic information are included in this issue.

libros Acceso Abierto
Agregar a Mi catálogo

30 years of the Comet Assay: an overview with some new insights

Más información

ISBNs: 9782889196494 (impreso)

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2015 Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica  

By means of this ‘Frontiers in Genetics’ research topic, we are celebrating 30 years of the Comet Assay. The first paper on this single-cell gel electrophoresis assay was published in 1984 by O. Ostling and K.J. Johanson (Biochem. Biophys. Res. Commun. Vol.123: 291-298). The comet assay is a versatile and sensitive method for measuring single - and double-strand breaks in DNA. By including lesion-specific enzymes in the assay, its range and sensitivity are greatly increased, but it is important to bear in mind that their specificity is not absolute. The comet assay (with and without inclusion of lesion-specific enzymes) is widely used as a biomarker assay in human population studies - primarily to measure DNA damage, but increasingly also to assess the capacity of cells for DNA repair. Ostling and Johanson (Biochem. Biophys. Res. Commun., 1984) were also the first to report experiments to measure DNA repair, by simply following the decrease of DNA damage over time after challenging cells with ionising radiation. However, this approach is time-consuming and laborious as it requires an extended period of cell culture and is therefore not ideal for biomonitoring studies, which typically require high-throughput processing of many samples. As an alternative approach, the in vitro comet-based repair assay was developed: a cell extract is incubated with a DNA substrate containing specific lesions, and DNA incisions accumulate. The in vitro comet-based repair assay has been modified and improved over the past decade: it was first devised to measure base excision repair of oxidised purines in lymphocytes (Collins et al., Mutagenesis, 2001), but has since been adapted for other lesions and thus other repair pathways, as well as being applied to tissue samples in addition to cell suspensions. Even after 30 years, the comet assay is still in a growth phase, with many new users each year. Many questions are repeatedly raised, which may seem to have self-evident answers, but clearly, it is necessary to reiterate them for the benefit of the new audience, and sometimes being forced to think again about old topics can shed new light. Different applications of the comet assay are discussed in this special issue, including: genotoxicity testing in different organisms, human biomonitoring, DNA repair studies, environmental biomonitoring and clinical studies. Furthermore, we consider and where possible answer questions, including the ones raised by Raymond Tice at the 8th International Comet Assay Workshop in Perugia (Italy 2009): What is the spectrum of DNA damage detected by the various versions of the comet assay?; What are the limitations associated with each application?; What should be done to standardize the assay for biomonitoring studies?; Can the comet assay be used to monitor changes in global methylation status?; What cell types are suitable for detecting genotoxic substances and their effects in vivo and in vitro?; Can the assay be fully automated?; and more. So this ‘Frontiers in Genetics’ research topic is written for the beginner as well as for the experienced users of the comet assay.

libros Acceso Abierto
Agregar a Mi catálogo

70 Years of Levothyroxine

Más información

978-3-030-63277-9 (en línea)

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere 2021 Directory of Open access Books acceso abierto
No requiere 2021 SpringerLink acceso abierto

Cobertura temática: Medicina básica - Medicina clínica  

Provides an excellent overview of 70 years of levothyroxine use in clinical practice. Discusses the effects of levothyroxine on heart, bone and in cancer.

libros Acceso Abierto
Agregar a Mi catálogo

A arte de enganar a natureza: contracepção, aborto e infanticídio no início do século XX

Más información

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica  


libros Acceso Abierto
Agregar a Mi catálogo

A Conversation about Healthy Eating

Más información

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No requiere Directory of Open access Books acceso abierto

Cobertura temática: Medicina básica