Catálogo de publicaciones - revistas
Nature Biotechnology
Resumen/Descripción – provisto por la editorial en inglés
Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com |
Información
Tipo de recurso:
revistas
ISSN impreso
1087-0156
ISSN electrónico
1546-1696
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1996-
Cobertura temática
Tabla de contenidos
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Zhen Zhang
; Amy E. Baxter; Diqiu Ren; Kunhua Qin; Zeyu Chen; Sierra M. Collins; Hua Huang; Chad A. Komar; Peter F. Bailer; Jared B. Parker; Gerd A. Blobel; Rahul M. Kohli; E. John Wherry; Shelley L. Berger; Junwei Shi
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Efficient evolution of human antibodies from general protein language models
Brian L. Hie; Varun R. Shanker; Duo Xu; Theodora U. J. Bruun; Payton A. Weidenbacher; Shaogeng Tang; Wesley Wu; John E. Pak; Peter S. Kim
<jats:title>Abstract</jats:title><jats:p>Natural evolution must explore a vast landscape of possible sequences for desirable yet rare mutations, suggesting that learning from natural evolutionary strategies could guide artificial evolution. Here we report that general protein language models can efficiently evolve human antibodies by suggesting mutations that are evolutionarily plausible, despite providing the model with no information about the target antigen, binding specificity or protein structure. We performed language-model-guided affinity maturation of seven antibodies, screening 20 or fewer variants of each antibody across only two rounds of laboratory evolution, and improved the binding affinities of four clinically relevant, highly mature antibodies up to sevenfold and three unmatured antibodies up to 160-fold, with many designs also demonstrating favorable thermostability and viral neutralization activity against Ebola and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudoviruses. The same models that improve antibody binding also guide efficient evolution across diverse protein families and selection pressures, including antibiotic resistance and enzyme activity, suggesting that these results generalize to many settings.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Precise integration of large DNA sequences in plant genomes using PrimeRoot editors
Chao Sun; Yuan Lei; Boshu Li; Qiang Gao; Yunjia Li; Wen Cao; Chao Yang; Hongchao Li; Zhiwei Wang; Yan Li; Yanpeng Wang; Jun Liu; Kevin Tianmeng Zhao; Caixia Gao
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
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Drug discovery companies are customizing ChatGPT: here’s how
Neil Savage
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Quantifying bias introduced by sample collection in relative and absolute microbiome measurements
Dylan G. Maghini; Mai Dvorak; Alex Dahlen; Morgan Roos; Scott Kuersten; Ami S. Bhatt
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
Viktoria Wagner; Fabian Kern; Oliver Hahn; Nicholas Schaum; Nicole Ludwig; Tobias Fehlmann; Annika Engel; Dominic Henn; Shusruto Rishik; Alina Isakova; Michelle Tan; Rene Sit; Norma Neff; Martin Hart; Eckart Meese; Steve Quake; Tony Wyss-Coray; Andreas Keller
<jats:title>Abstract</jats:title><jats:p>Molecular mechanisms of organismal and cell aging remain incompletely understood. We, therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 organs at ten timepoints from 1 to 27 months) and rejuvenated mice. We found molecular aging trajectories are largely tissue-specific except for eight broadly deregulated microRNAs (miRNAs). Their individual abundance mirrors their presence in circulating plasma and extracellular vesicles (EVs) whereas tissue-specific ncRNAs were less present. For miR-29c-3p, we observe the largest correlation with aging in solid organs, plasma and EVs. In mice rejuvenated by heterochronic parabiosis, miR-29c-3p was the most prominent miRNA restored to similar levels found in young liver. miR-29c-3p targets the extracellular matrix and secretion pathways, known to be implicated in aging. We provide a map of organism-wide expression of ncRNAs with aging and rejuvenation and identify a set of broadly deregulated miRNAs, which may function as systemic regulators of aging via plasma and EVs.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Inferring cell–cell communication at single-cell resolution
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Can microbes save the planet?
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
After GLP-1, what’s next for weight loss?
Melanie Senior
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
High-throughput RNA isoform sequencing using programmed cDNA concatenation
Aziz M. Al’Khafaji; Jonathan T. Smith; Kiran V. Garimella; Mehrtash Babadi; Victoria Popic; Moshe Sade-Feldman; Michael Gatzen; Siranush Sarkizova; Marc A. Schwartz; Emily M. Blaum; Allyson Day; Maura Costello; Tera Bowers; Stacey Gabriel; Eric Banks; Anthony A. Philippakis; Genevieve M. Boland; Paul C. Blainey; Nir Hacohen
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible