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Nature Biotechnology

Resumen/Descripción – provisto por la editorial en inglés
Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.
Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 2012 / hasta dic. 2023 Nature.com

Información

Tipo de recurso:

revistas

ISSN impreso

1087-0156

ISSN electrónico

1546-1696

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Tabla de contenidos

Shoot the messenger: RNA editing is here

Cormac Sheridan

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Women build strength in numbers

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Rapid-response manufacturing of adenovirus-vectored vaccines

Carina C. D. JoeORCID; Nitin Chopra; Piergiuseppe Nestola; Julia Niemann; Alexander D. DouglasORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Tuning plant phenotypes by precise, graded downregulation of gene expression

Chenxiao Xue; Fengti Qiu; Yuxiang Wang; Boshu Li; Kevin Tianmeng ZhaoORCID; Kunling Chen; Caixia GaoORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Engineered upstream open reading frames predictably downregulate mRNA translation in plants

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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An integrated platform for high-throughput nanoscopy

Andrew E. S. Barentine; Yu Lin; Edward M. Courvan; Phylicia KiddORCID; Miao Liu; Leonhard BaldufORCID; Timy Phan; Felix Rivera-Molina; Michael R. Grace; Zach MarinORCID; Mark LessardORCID; Juliana Rios Chen; Siyuan WangORCID; Karla M. NeugebauerORCID; Joerg BewersdorfORCID; David BaddeleyORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Imaging large cell populations with fast, automated super-resolution

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Adrian GottschlichORCID; Moritz ThomasORCID; Ruth GrünmeierORCID; Stefanie LeschORCID; Lisa Rohrbacher; Veronika IglORCID; Daria BriukhovetskaORCID; Mohamed-Reda Benmebarek; Binje VickORCID; Sertac DedeORCID; Katharina Müller; Tao Xu; Dario Dhoqina; Florian MärklORCID; Sophie Robinson; Andrea Sendelhofert; Heiko Schulz; Öykü Umut; Vladyslav Kavaka; Christina Angeliki Tsiverioti; Emanuele Carlini; Sayantan Nandi; Thaddäus StrzalkowskiORCID; Theo LorenziniORCID; Sophia StockORCID; Philipp Jie Müller; Janina Dörr; Matthias SeifertORCID; Bruno L. CadilhaORCID; Ruben Brabenec; Natalie Röder; Felicitas Rataj; Manuel Nüesch; Franziska ModemannORCID; Jasmin Wellbrock; Walter Fiedler; Christian KellnerORCID; Eduardo BeltránORCID; Tobias HeroldORCID; Dominik PaquetORCID; Irmela Jeremias; Louisa von BaumgartenORCID; Stefan Endres; Marion Subklewe; Carsten MarrORCID; Sebastian KoboldORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Contamination source modeling with SCRuB improves cancer phenotype prediction from microbiome data

George I. Austin; Heekuk ParkORCID; Yoli Meydan; Dwayne Seeram; Tanya Sezin; Yue Clare LouORCID; Brian A. Firek; Michael J. Morowitz; Jillian F. BanfieldORCID; Angela M. ChristianoORCID; Itsik Pe’er; Anne-Catrin Uhlemann; Liat ShenhavORCID; Tal KoremORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Global detection of human variants and isoforms by deep proteome sequencing

Pavel Sinitcyn; Alicia L. Richards; Robert J. Weatheritt; Dain R. Brademan; Harald Marx; Evgenia Shishkova; Jesse G. MeyerORCID; Alexander S. Hebert; Michael S. Westphall; Benjamin J. BlencoweORCID; Jürgen CoxORCID; Joshua J. CoonORCID

<jats:title>Abstract</jats:title><jats:p>An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically identified by peptide sequences representing a small fraction of their total amino acids. Hence, an average shotgun experiment fails to distinguish different protein variants and isoforms. Deeper proteome sequencing is therefore required for the global discovery of protein isoforms. Using six different human cell lines, six proteases, deep fractionation and three tandem mass spectrometry fragmentation methods, we identify a million unique peptides from 17,717 protein groups, with a median sequence coverage of approximately 80%. Direct comparison with RNA expression data provides evidence for the translation of most nonsynonymous variants. We have also hypothesized that undetected variants likely arise from mutation-induced protein instability. We further observe comparable detection rates for exon–exon junction peptides representing constitutive and alternative splicing events. Our dataset represents a resource for proteoform discovery and provides direct evidence that most frame-preserving alternatively spliced isoforms are translated.</jats:p>

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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