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Nature Biotechnology

Resumen/Descripción – provisto por la editorial en inglés
Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.
Palabras clave – provistas por la editorial

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 2012 / hasta dic. 2023 Nature.com

Información

Tipo de recurso:

revistas

ISSN impreso

1087-0156

ISSN electrónico

1546-1696

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Tabla de contenidos

The potential of DAOs for funding and collaborative development in the life sciences

Simone Fantaccini; Laura GrassiORCID; Andrea Rampoldi

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

The covariance environment defines cellular niches for spatial inference

Doron Haviv; Ján RemšíkORCID; Mohamed GatieORCID; Catherine Snopkowski; Meril Takizawa; Nathan Pereira; John Bashkin; Stevan JovanovichORCID; Tal NawyORCID; Ronan ChaligneORCID; Adrienne Boire; Anna-Katerina Hadjantonakis; Dana Pe’erORCID

<jats:title>Abstract</jats:title><jats:p>A key challenge of analyzing data from high-resolution spatial profiling technologies is to suitably represent the features of cellular neighborhoods or niches. Here we introduce the covariance environment (COVET), a representation that leverages the gene–gene covariate structure across cells in the niche to capture the multivariate nature of cellular interactions within it. We define a principled optimal transport-based distance metric between COVET niches that scales to millions of cells. Using COVET to encode spatial context, we developed environmental variational inference (ENVI), a conditional variational autoencoder that jointly embeds spatial and single-cell RNA sequencing data into a latent space. ENVI includes two decoders: one to impute gene expression across the spatial modality and a second to project spatial information onto single-cell data. ENVI can confer spatial context to genomics data from single dissociated cells and outperforms alternatives for imputing gene expression on diverse spatial datasets.</jats:p>

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Genetically encoding colors and images into bioengineered microbial materials

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression

Kenneth T. Walker; Ivy S. LiORCID; Jennifer Keane; Vivianne J. Goosens; Wenzhe Song; Koon-Yang Lee; Tom EllisORCID

<jats:title>Abstract</jats:title><jats:p>Environmental concerns are driving interest in postpetroleum synthetic textiles produced from microbial and fungal sources. Bacterial cellulose (BC) is a promising sustainable leather alternative, on account of its material properties, low infrastructure needs and biodegradability. However, for alternative textiles like BC to be fully sustainable, alternative ways to dye textiles need to be developed alongside alternative production methods. To address this, we genetically engineer <jats:italic>Komagataeibacter rhaeticus</jats:italic> to create a bacterial strain that grows self-pigmenting BC. Melanin biosynthesis in the bacteria from recombinant tyrosinase expression achieves dark black coloration robust to material use. Melanated BC production can be scaled up for the construction of prototype fashion products, and we illustrate the potential of combining engineered self-pigmentation with tools from synthetic biology, through the optogenetic patterning of gene expression in cellulose-producing bacteria. With this study, we demonstrate that combining genetic engineering with current and future methods of textile biofabrication has the potential to create a new class of textiles.</jats:p>

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Antivenom slithers back to life

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible