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Nature Biotechnology
Resumen/Descripción – provisto por la editorial en inglés
Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com |
Información
Tipo de recurso:
revistas
ISSN impreso
1087-0156
ISSN electrónico
1546-1696
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1996-
Cobertura temática
Tabla de contenidos
TRGT-ing the dark genome to accurately characterize tandem repeats at scale
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
An adenine base editor variant expands context compatibility
Yu-Lan Xiao
; Yuan Wu; Weixin Tang
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Detection of mosaic and population-level structural variants with Sniffles2
Moritz Smolka; Luis F. Paulin; Christopher M. Grochowski; Dominic W. Horner; Medhat Mahmoud; Sairam Behera; Ester Kalef-Ezra; Mira Gandhi; Karl Hong; Davut Pehlivan; Sonja W. Scholz; Claudia M. B. Carvalho; Christos Proukakis; Fritz J. Sedlazeck
<jats:title>Abstract</jats:title><jats:p>Calling structural variations (SVs) is technically challenging, but using long reads remains the most accurate way to identify complex genomic alterations. Here we present Sniffles2, which improves over current methods by implementing a repeat aware clustering coupled with a fast consensus sequence and coverage-adaptive filtering. Sniffles2 is 11.8 times faster and 29% more accurate than state-of-the-art SV callers across different coverages (5–50×), sequencing technologies (ONT and HiFi) and SV types. Furthermore, Sniffles2 solves the problem of family-level to population-level SV calling to produce fully genotyped VCF files. Across 11 probands, we accurately identified causative SVs around <jats:italic>MECP2</jats:italic>, including highly complex alleles with three overlapping SVs. Sniffles2 also enables the detection of mosaic SVs in bulk long-read data. As a result, we identified multiple mosaic SVs in brain tissue from a patient with multiple system atrophy. The identified SV showed a remarkable diversity within the cingulate cortex, impacting both genes involved in neuron function and repetitive elements.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology
Daiwei Zhang; Amelia Schroeder; Hanying Yan; Haochen Yang; Jian Hu; Michelle Y. Y. Lee; Kyung S. Cho; Katalin Susztak; George X. Xu; Michael D. Feldman; Edward B. Lee; Emma E. Furth; Linghua Wang; Mingyao Li
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Fast mass spectrometry search and clustering of untargeted metabolomics data
Mihir Mongia; Tyler M. Yasaka; Yudong Liu; Mustafa Guler; Liang Lu; Aditya Bhagwat; Bahar Behsaz; Mingxun Wang; Pieter C. Dorrestein; Hosein Mohimani
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
Qing Dai; Chang Ye; Iryna Irkliyenko; Yiding Wang; Hui-Lung Sun; Yun Gao; Yushuai Liu; Alana Beadell; José Perea; Ajay Goel; Chuan He
<jats:title>Abstract</jats:title><jats:p>Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion of certain DNA sequences. We present ultrafast BS-seq (UBS-seq), which uses highly concentrated bisulfite reagents and high reaction temperatures to accelerate the bisulfite reaction by ~13-fold, resulting in reduced DNA damage and lower background noise. UBS-seq allows library construction from small amounts of purified genomic DNA, such as from cell-free DNA or directly from 1 to 100 mouse embryonic stem cells, with less overestimation of 5mC level and higher genome coverage than conventional BS-seq. Additionally, UBS-seq quantitatively maps RNA 5-methylcytosine (m<jats:sup>5</jats:sup>C) from low inputs of mRNA and allows the detection of m<jats:sup>5</jats:sup>C stoichiometry in highly structured RNA sequences. Our UBS-seq results identify NSUN2 as the major ‘writer’ protein responsible for the deposition of ~90% of m<jats:sup>5</jats:sup>C sites in HeLa mRNA and reveal enriched m<jats:sup>5</jats:sup>C sites in 5′-regions of mammalian mRNA, which may have functional roles in mRNA translation regulation.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Characterization and visualization of tandem repeats at genome scale
Egor Dolzhenko; Adam English; Harriet Dashnow; Guilherme De Sena Brandine; Tom Mokveld; William J. Rowell; Caitlin Karniski; Zev Kronenberg; Matt C. Danzi; Warren A. Cheung; Chengpeng Bi; Emily Farrow; Aaron Wenger; Khi Pin Chua; Verónica Martínez-Cerdeño; Trevor D. Bartley; Peng Jin; David L. Nelson; Stephan Zuchner; Tomi Pastinen; Aaron R. Quinlan; Fritz J. Sedlazeck; Michael A. Eberle
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
High-quality metagenome assembly from long accurate reads with metaMDBG
Gaëtan Benoit; Sébastien Raguideau; Robert James; Adam M. Phillippy; Rayan Chikhi; Christopher Quince
<jats:title>Abstract</jats:title><jats:p>We introduce metaMDBG, a metagenomics assembler for PacBio HiFi reads. MetaMDBG combines a de Bruijn graph assembly in a minimizer space with an iterative assembly over sequences of minimizers to address variations in genome coverage depth and an abundance-based filtering strategy to simplify strain complexity. For complex communities, we obtained up to twice as many high-quality circularized prokaryotic metagenome-assembled genomes as existing methods and had better recovery of viruses and plasmids.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells
Lijun Ye; Dongdong Zhao; Ju Li; Yiran Wang; Bo Li; Yuanzhao Yang; Xueting Hou; Huibin Wang; Zhandong Wei; Xiaoqi Liu; Yaqiu Li; Siwei Li; Yajing Liu; Xueli Zhang; Changhao Bi
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR
Liming Luo; Jocelyn Duen-Ya Jea; Yan Wang; Pei-Wen Chao; Laising Yen
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible