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Nature Biotechnology

Resumen/Descripción – provisto por la editorial en inglés
Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.
Palabras clave – provistas por la editorial

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 2012 / hasta dic. 2023 Nature.com

Información

Tipo de recurso:

revistas

ISSN impreso

1087-0156

ISSN electrónico

1546-1696

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Tabla de contenidos

High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler

Taras Sych; Jan Schlegel; Hanna M. G. Barriga; Miina Ojansivu; Leo HankeORCID; Florian WeberORCID; R. Beklem BostanciogluORCID; Kariem Ezzat; Herbert Stangl; Birgit PlochbergerORCID; Jurga Laurencikiene; Samir El AndaloussiORCID; Daniel Fürth; Molly M. StevensORCID; Erdinc SezginORCID

<jats:title>Abstract</jats:title><jats:p>We introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5–200 nm. We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses.</jats:p>

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Staple crops equipped for alkaline soils

Caitlin S. ByrtORCID; A. Harvey Millar; Rana MunnsORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang ChenORCID; Mengjia Hong; Changming Luan; Hongyi Gao; Gaomeng Ru; Xinyuan Guo; Dujuan Zhang; Shun Zhang; Changwei Li; Jun Wu; Peyton B. Randolph; Alexander A. Sousa; Chao Qu; Yifan Zhu; Yuting Guan; Liren Wang; Mingyao LiuORCID; Bo FengORCID; Gaojie SongORCID; David R. LiuORCID; Dali LiORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

A call for an ‘Asilomar’ for cultivated meat and seafood

Sveva Bottini; Claudia Fuoco; Nike Schiavo; Alessandro BerteroORCID; Stefano BiressiORCID; Luciano ContiORCID; Cesare GargioliORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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Breaking boundaries in whole-body imaging and disease understanding with wildDISCO

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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The global patent landscape of mRNA for diagnosis and therapy

Mengru Lyu; Jiyuan ChenORCID; Yeheng Peng; Fang Han; Luyao Gong; Jingfei Guo; Lijuan Tian; Yuan GaoORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. 1193-1199

Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens

Zihan XuORCID; Andras Sziraki; Jasper Lee; Wei Zhou; Junyue CaoORCID

<jats:title>Abstract</jats:title><jats:p>We present a combinatorial indexing method, <jats:italic>PerturbSci-Kinetics</jats:italic>, for capturing whole transcriptomes, nascent transcriptomes and single guide RNA (sgRNA) identities across hundreds of genetic perturbations at the single-cell level. Profiling a pooled CRISPR screen targeting various biological processes, we show the gene expression regulation during RNA synthesis, processing and degradation, miRNA biogenesis and mitochondrial mRNA processing, systematically decoding the genome-wide regulatory network that underlies RNA temporal dynamics at scale.</jats:p>

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses

Menglin WangORCID; Benoit RousseauORCID; Kunyu Qiu; Guannan Huang; Yu Zhang; Hang Su; Christine Le Bihan-Benjamin; Ines Khati; Oliver ArtzORCID; Michael B. FooteORCID; Yung-Yi ChengORCID; Kuo-Hsiung Lee; Michael Z. Miao; Yue Sun; Philippe-Jean BousquetORCID; Marc Hilmi; Elise Dumas; Anne-Sophie Hamy; Fabien Reyal; Lin Lin; Paul M. Armistead; Wantong Song; Ava Vargason; Janelle C. ArthurORCID; Yun Liu; Jianfeng GuoORCID; Xuefei Zhou; Juliane Nguyen; Yongqun HeORCID; Jenny P.-Y. Ting; Aaron C. Anselmo; Leaf HuangORCID

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible

Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes

Kunal JindalORCID; Mohd Tayyab Adil; Naoto YamaguchiORCID; Xue Yang; Helen C. WangORCID; Kenji KamimotoORCID; Guillermo C. Rivera-Gonzalez; Samantha A. MorrisORCID

<jats:title>Abstract</jats:title><jats:p>Complex gene regulatory mechanisms underlie differentiation and reprogramming. Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA barcodes to combine cell lineage readout with single-cell transcriptomics. However, reliance on transcriptional profiling limits adaptation to other single-cell assays. With CellTag-multi, we present an approach that enables direct capture of heritable random barcodes expressed as polyadenylated transcripts, in both single-cell RNA sequencing and single-cell Assay for Transposase Accessible Chromatin using sequencing assays, allowing for independent clonal tracking of transcriptional and epigenomic cell states. We validate CellTag-multi to characterize progenitor cell lineage priming during mouse hematopoiesis. Additionally, in direct reprogramming of fibroblasts to endoderm progenitors, we identify core regulatory programs underlying on-target and off-target fates. Furthermore, we reveal the transcription factor Zfp281 as a regulator of reprogramming outcome, biasing cells toward an off-target mesenchymal fate. Our results establish CellTag-multi as a lineage-tracing method compatible with multiple single-cell modalities and demonstrate its utility in revealing fate-specifying gene regulatory changes across diverse paradigms of differentiation and reprogramming.</jats:p>

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

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From air to your plate: tech startups making food from atmospheric CO2

Claire Turrell

Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.

Pp. No disponible