Catálogo de publicaciones - revistas
Nature Biotechnology
Resumen/Descripción – provisto por la editorial en inglés
Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com |
Información
Tipo de recurso:
revistas
ISSN impreso
1087-0156
ISSN electrónico
1546-1696
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1996-
Cobertura temática
Tabla de contenidos
Reducing the costs of blockbuster gene and cell therapies in the Global South
Ben Johnson
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
The challenges and promise of sweat sensing
Noelle Davis
; Jason Heikenfeld; Carlos Milla; Ali Javey
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
In vivo human T cell engineering with enveloped delivery vehicles
Jennifer R. Hamilton; Evelyn Chen; Barbara S. Perez; Cindy R. Sandoval Espinoza; Min Hyung Kang; Marena Trinidad; Wayne Ngo; Jennifer A. Doudna
<jats:title>Abstract</jats:title><jats:p>Viruses and virally derived particles have the intrinsic capacity to deliver molecules to cells, but the difficulty of readily altering cell-type selectivity has hindered their use for therapeutic delivery. Here, we show that cell surface marker recognition by antibody fragments displayed on membrane-derived particles encapsulating CRISPR–Cas9 protein and guide RNA can deliver genome editing tools to specific cells. Compared to conventional vectors like adeno-associated virus that rely on evolved capsid tropisms to deliver virally encoded cargo, these Cas9-packaging enveloped delivery vehicles (Cas9-EDVs) leverage predictable antibody–antigen interactions to transiently deliver genome editing machinery selectively to cells of interest. Antibody-targeted Cas9-EDVs preferentially confer genome editing in cognate target cells over bystander cells in mixed populations, both ex vivo and in vivo. By using multiplexed targeting molecules to direct delivery to human T cells, Cas9-EDVs enable the generation of genome-edited chimeric antigen receptor T cells in humanized mice, establishing a programmable delivery modality with the potential for widespread therapeutic utility.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Disentanglement of single-cell data with biolord
Zoe Piran; Niv Cohen; Yedid Hoshen; Mor Nitzan
<jats:title>Abstract</jats:title><jats:p>Biolord is a deep generative method for disentangling single-cell multi-omic data to known and unknown attributes, including spatial, temporal and disease states, used to reveal the decoupled biological signatures over diverse single-cell modalities and biological systems. By virtually shifting cells across states, biolord generates experimentally inaccessible samples, outperforming state-of-the-art methods in predictions of cellular response to unseen drugs and genetic perturbations. Biolord is available at <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://github.com/nitzanlab/biolord">https://github.com/nitzanlab/biolord</jats:ext-link>.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Wearable ultrasound for continuous deep-tissue monitoring
Jon-Emile S. Kenny
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing
Jiao Cao; Zhong Zheng; Di Sun; Xin Chen; Rui Cheng; Tianpeng Lv; Yu An; Junhua Zheng; Jia Song; Lingling Wu; Chaoyong Yang
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
KARR-seq reveals cellular higher-order RNA structures and RNA–RNA interactions
Tong Wu; Anthony Youzhi Cheng; Yuexiu Zhang; Jiayu Xu; Jinjun Wu; Li Wen; Xiao Li; Bei Liu; Xiaoyang Dou; Pingluan Wang; Linda Zhang; Jingyi Fei; Jianrong Li; Zhengqing Ouyang; Chuan He
<jats:title>Abstract</jats:title><jats:p>RNA fate and function are affected by their structures and interactomes. However, how RNA and RNA-binding proteins (RBPs) assemble into higher-order structures and how RNA molecules may interact with each other to facilitate functions remain largely unknown. Here we present KARR-seq, which uses N<jats:sub>3</jats:sub>-kethoxal labeling and multifunctional chemical crosslinkers to covalently trap and determine RNA–RNA interactions and higher-order RNA structures inside cells, independent of local protein binding to RNA. KARR-seq depicts higher-order RNA structure and detects widespread intermolecular RNA–RNA interactions with high sensitivity and accuracy. Using KARR-seq, we show that translation represses mRNA compaction under native and stress conditions. We determined the higher-order RNA structures of respiratory syncytial virus (RSV) and vesicular stomatitis virus (VSV) and identified RNA–RNA interactions between the viruses and the host RNAs that potentially regulate viral replication.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
KARR-seq maps higher-order RNA structures and RNA–RNA interactions across the transcriptome
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Publisher Correction: Detection of mosaic and population-level structural variants with Sniffles2
Moritz Smolka; Luis F. Paulin; Christopher M. Grochowski; Dominic W. Horner; Medhat Mahmoud; Sairam Behera; Ester Kalef-Ezra; Mira Gandhi; Karl Hong; Davut Pehlivan; Sonja W. Scholz; Claudia M. B. Carvalho; Christos Proukakis; Fritz J. Sedlazeck
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Eavesdropping on brain organoids
James Newton Brandt; Priya Rajasethupathy
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible