Catálogo de publicaciones - revistas
Nature Biotechnology
Resumen/Descripción – provisto por la editorial en inglés
Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com |
Información
Tipo de recurso:
revistas
ISSN impreso
1087-0156
ISSN electrónico
1546-1696
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1996-
Cobertura temática
Tabla de contenidos
Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells
Lijun Ye; Dongdong Zhao
; Ju Li; Yiran Wang; Bo Li; Yuanzhao Yang; Xueting Hou; Huibin Wang; Zhandong Wei; Xiaoqi Liu; Yaqiu Li; Siwei Li; Yajing Liu; Xueli Zhang; Changhao Bi
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR
Liming Luo; Jocelyn Duen-Ya Jea; Yan Wang; Pei-Wen Chao; Laising Yen
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
Yang Zhao; Jiangqing Chen; Massimo Andreatta; Bing Feng; Yu-Qing Xie; Mathias Wenes; Yi Wang; Min Gao; Xiaomeng Hu; Pedro Romero; Santiago Carmona; Jie Sun; Yugang Guo; Li Tang
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Programmable protein expression using a genetically encoded m6A sensor
Bahjat F. Marayati; Matthew G. Thompson; Christopher L. Holley; Stacy M. Horner; Kate D. Meyer
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
GEMS enables mRNA m6A methylation sensing in living cells and m6A-coupled protein delivery
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Metabolically enhanced CAR T cells efficiently clear solid tumors in mice
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons
Emiliano Hergenreder; Andrew P. Minotti; Yana Zorina; Polina Oberst; Zeping Zhao; Hermany Munguba; Elizabeth L. Calder; Arianna Baggiolini; Ryan M. Walsh; Conor Liston; Joshua Levitz; Ralph Garippa; Shuibing Chen; Gabriele Ciceri; Lorenz Studer
<jats:title>Abstract</jats:title><jats:p>The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months to years for reaching adult-like function. Prolonged in vitro maturation presents a major challenge to stem cell-based applications in modeling and treating neurological disease. Therefore, we designed a high-content imaging assay based on morphological and functional readouts in hPSC-derived cortical neurons which identified multiple compounds that drive neuronal maturation including inhibitors of lysine-specific demethylase 1 and disruptor of telomerase-like 1 and activators of calcium-dependent transcription. A cocktail of four factors, GSK2879552, EPZ-5676, <jats:italic>N</jats:italic>-methyl-<jats:sc>d</jats:sc>-aspartate and Bay K 8644, collectively termed GENtoniK, triggered maturation across all parameters tested, including synaptic density, electrophysiology and transcriptomics. Maturation effects were further validated in cortical organoids, spinal motoneurons and non-neural lineages including melanocytes and pancreatic β-cells. The effects on maturation observed across a broad range of hPSC-derived cell types indicate that some of the mechanisms controlling the timing of human maturation might be shared across lineages.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion
Jonathan C. Schmok; Manya Jain; Lena A. Street; Alex T. Tankka; Danielle Schafer; Hsuan-Lin Her; Sara Elmsaouri; Maya L. Gosztyla; Evan A. Boyle; Pratibha Jagannatha; En-Ching Luo; Ester J. Kwon; Marko Jovanovic; Gene W. Yeo
<jats:title>Abstract</jats:title><jats:p>RNA-binding proteins (RBPs) modulate alternative splicing outcomes to determine isoform expression and cellular survival. To identify RBPs that directly drive alternative exon inclusion, we developed tethered function luciferase-based splicing reporters that provide rapid, scalable and robust readouts of exon inclusion changes and used these to evaluate 718 human RBPs. We performed enhanced cross-linking immunoprecipitation, RNA sequencing and affinity purification–mass spectrometry to investigate a subset of candidates with no prior association with splicing. Integrative analysis of these assays indicates surprising roles for TRNAU1AP, SCAF8 and RTCA in the modulation of hundreds of endogenous splicing events. We also leveraged our tethering assays and top candidates to identify potent and compact exon inclusion activation domains for splicing modulation applications. Using these identified domains, we engineered programmable fusion proteins that outperform current artificial splicing factors at manipulating inclusion of reporter and endogenous exons. This tethering approach characterizes the ability of RBPs to induce exon inclusion and yields new molecular parts for programmable splicing control.</jats:p>
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
Identification of a chemical cocktail that drives the maturation of human neurons
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible
A step closer to safe and efficient mammalian gene regulation
Palabras clave: Biomedical Engineering; Molecular Medicine; Applied Microbiology and Biotechnology; Bioengineering; Biotechnology.
Pp. No disponible