Catálogo de publicaciones - revistas

<jats:p> Endogenous retroviruses are abundant components of mammalian genomes descended from ancient germline infections. In several mammals, the envelope proteins encoded by these elements protect against exogenous viruses, but this activity has not been documented with endogenously expressed envelopes in humans. We report that the human genome harbors a large pool of envelope-derived sequences with the potential to restrict retroviral infection. To test this, we characterized an envelope-derived protein, Suppressyn. We found that <jats:italic>Suppressyn</jats:italic> is expressed in human preimplantation embryos and developing placenta using its ancestral retroviral promoter. Cell culture assays showed that <jats:italic>Suppressyn</jats:italic> , and its hominoid orthologs, could restrict infection by extant mammalian type D retroviruses. Our data support a generalizable model of retroviral envelope co-option for host immunity and genome defense. </jats:p>

<jats:p>COVID-19 vaccination causes small changes to menstruation that quickly resolve</jats:p>

<jats:p> The large diversity of cell types in nervous systems presents a challenge in identifying the genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the <jats:italic>Drosophila</jats:italic> visual system can each be defined by unique combinations of on average 10 continuously expressed transcription factors. We show that targeted modifications of this terminal selector code induce predictable conversions of neuronal fates that appear morphologically and transcriptionally complete. Cis-regulatory analysis of open chromatin links one of these genes to an upstream patterning factor that specifies neuronal fates in stem cells. Experimentally validated network models describe the synergistic regulation of downstream effectors by terminal selectors and ecdysone signaling during brain wiring. Our results provide a generalizable framework of how specific fates are implemented in postmitotic neurons. </jats:p>

<jats:p>Study of famed meteorite by quantum microscope hints at planet’s prolonged habitability</jats:p>

<jats:p>Budgets of many civilian science agencies will grow, but not always by as much as White House had requested</jats:p>

<jats:p>As unreviewed studies proliferate online, researchers are eyeing ways to boost critiques</jats:p>

<jats:p>Agency violated federal law when it prevented former lab primates from entering Chimp Haven, federal judge rules</jats:p>

<jats:p>Technique is designed to treat mitochondrial disease</jats:p>

<jats:p>Public health officials have drawn on a decade of research to craft a plan to make New Zealand smoke-free</jats:p>