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The EBMT Handbook

Enric Carreras ; Carlo Dufour ; Mohamad Mohty ; Nicolaus Kröger (eds.)

7th ed. 2019.

Resumen/Descripción – provisto por la editorial

No disponible.

Palabras clave – provistas por la editorial

Hematology; Transplant Surgery; Blood Transfusion Medicine; Pediatric Surgery; Surgical Oncology

Disponibilidad
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No requiere 2019 SpringerLink acceso abierto

Información

Tipo de recurso:

libros

ISBN impreso

978-3-030-02277-8

ISBN electrónico

978-3-030-02278-5

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Información sobre derechos de publicación

© EBMT and the Author(s) 2019

Cobertura temática

medicina-clinica

Medicina clínica

salud

Ciencias de la salud

Tabla de contenidos

doi: 10.1007/978-3-030-02278-5_70

Acute Myeloid Leukemia in Children

Brenda E. S. Gibson; Martin G. Sauer; Persis Amrolia

The outcome for children with acute myeloid leukemia (AML) has serially improved over the past three decades with an overall survival (OS) of 70–75% and event-free survival (EFS) of 60–65% widely reported. Much of this improvement is due to better supportive care, optimization of intensity of treatment including employment of Haematopoietic Stem Cell Transplantation (HSCT) in 1st complete remission (CR1) and better salvage in 2nd complete remission (CR2).

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 523-530

doi: 10.1007/978-3-030-02278-5_71

Acute Lymphoblastic Leukemia in Adults

Matthias Stelljes; David I. Marks

ALL is a malignant transformation and proliferation of lymphoid progenitor cells in the bone marrow, blood, and extramedullary sites. While 80% of ALL occurs in children, it represents a devastating disease in adults.

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 531-538

doi: 10.1007/978-3-030-02278-5_72

Acute Lymphoblastic Leukemia in Children and Adolescents

Christina Peters; Franco Locatelli; Peter Bader

Although the majority of children and adolescents with acute lymphoblastic leukemia (ALL) are curable with current chemotherapy regimens, poor outcome persists in some individuals (Eckert et al. 2011; von Stackelberg et al. 2011; Schrappe et al. 2012).

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 539-545

doi: 10.1007/978-3-030-02278-5_73

Myelodysplastic Syndromes

Marie Robin; Theo de Witte

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by hypercellular bone marrow, peripheral cytopenias, and dysplastic features in blood and bone marrow.

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 547-556

doi: 10.1007/978-3-030-02278-5_74

Pediatric MDS Including Refractory Cytopenia and Juvenile Myelomonocytic Leukemia

Charlotte M. Niemeyer

For pediatric patients with MDS and 2–19% blasts in the PB or 5–19% blasts in the BM, the same diagnostic criteria utilized for adults with MDS with excess blasts (MDS-EB) are applied (WHO).

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 557-560

doi: 10.1007/978-3-030-02278-5_75

Myelodysplastic/Myeloproliferative Neoplasms

Francesco Onida; Yves Chalandon

The myelodysplastic syndrome-myeloproliferative neoplasms (MDS/MPNs) are a heterogeneous group of hematologic malignancies characterized by dysplastic and myeloproliferative clinical, laboratory, and morphological overlapping features, both in marrow and in blood.

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 561-568

doi: 10.1007/978-3-030-02278-5_76

Myeloproliferative Neoplasms

Nicolaus Kröger; Yves Chalandon

Polycythemia vera (PV) and essential thrombocythemia (ET) have a favorable outcome without need for allo-HSCT unless the disease progressed to post-ET/PV myelofibrosis or secondary AML (Lussana et al. 2014).

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 569-578

doi: 10.1007/978-3-030-02278-5_77

Severe Aplastic Anemia and PNH

Régis Peffault de Latour; Antonio Risitano; Carlo Dufour

Severe aplastic anemia (SAA) is an autoimmune disorder (AID) due to the attack of autoreactive cytotoxic T lymphocytes to the hematopoietic component of the bone marrow.

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 579-585

doi: 10.1007/978-3-030-02278-5_78

Fanconi’s Anemia and Other Hereditary Bone Marrow Failure Syndromes

Cristina Díaz de Heredia; Marc Bierings; Jean-Hugues Dalle; Francesca Fioredda; Brigitte Strahm

Inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of rare blood disorders due to hematopoiesis impairment, with different clinical presentations and pathogenic mechanisms.

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 587-593

doi: 10.1007/978-3-030-02278-5_79

Hemoglobinopathies (Sickle Cell Disease and Thalassemia)

Barbara Cappelli; Eliane Gluckman; Khaled Ghanem; Miguel R. Abboud

Sickle cell disease (SCD) is the most common inherited hemoglobinopathy worldwide.

Part IX - Indications and Results Topic leaders: Rafael Duarte and Nicolaus Kröger | Pp. 595-601