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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

Palabras clave – provistas por la editorial

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No detectada	desde jul. 2012 / hasta dic. 2023	Nature.com
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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

Tabla de contenidos

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doi: 10.1038/d41586-022-02030-1

Daily briefing: How faecal transplants could boost cancer treatments

Flora Graham

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-01950-2

Prior Omicron infection protects against BA.4 and BA.5 variants

McKenzie Prillaman

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/s41586-022-05116-y

Organizing structural principles of the IL-17 ligandâ€“receptor axis

Steven C. Wilson; Nathanael A. Caveney; Michelle Yen; Christoph Pollmann; Xinyu Xiang; Kevin M. Jude; Maximillian Hafer; Naotaka Tsutsumi; Jacob Piehler; K. Christopher Garcia

<jats:title>Abstract</jats:title><jats:p>The IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases<jats:sup>1</jats:sup>. The compositions and structures of functional IL-17 family ligandâ€“receptor signalling assemblies remain unclear. IL-17E (also known as IL-25) is a key regulator of type 2 immune responses and driver of inflammatory diseases, such as allergic asthma, and requires both IL-17 receptor A (IL-17RA) and IL-17RB to elicit functional responses<jats:sup>2</jats:sup>. Here we studied IL-25â€“IL-17RB binary and IL-25â€“IL-17RBâ€“IL-17RA ternary complexes using a combination of cryo-electron microscopy, single-molecule imaging and cell-based signalling approaches. The IL-25â€“IL-17RBâ€“IL-17RA ternary signalling assembly is a C2-symmetric complex in which the IL-25â€“IL-17RB homodimer is flanked by two â€˜wing-likeâ€™ IL-17RA co-receptors through a â€˜tip-to-tipâ€™ geometry that is the key receptorâ€“receptor interaction required for initiation of signal transduction. IL-25 interacts solely with IL-17RB to allosterically promote the formation of the IL-17RBâ€“IL-17RA tip-to-tip interface. The resulting large separation between the receptors at the membrane-proximal level may reflect proximity constraints imposedÂ by the intracellular domains for signalling. Cryo-electron microscopy structures of IL-17Aâ€“IL-17RA and IL-17Aâ€“IL-17RAâ€“IL-17RC complexes reveal that this tip-to-tip architecture is a key organizing principle of the IL-17 receptor family. Furthermore, these studies reveal dual actions for IL-17RA sharing among IL-17 cytokine complexes, by either directly engaging IL-17 cytokines or alternatively functioning as a co-receptor.</jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible