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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Ex-Google chief’s venture aims to save neglected science software
David Matthews
Palabras clave: Multidisciplinary.
Pp. 410-411
We built a science institute from scratch
Bianca Nogrady
Palabras clave: Multidisciplinary.
Pp. 414-414
‘Mathematics is an unknown land’: meet Fields Medal winner Maryna Viazovska
Davide Castelvecchi
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Hawaii law could break years-long astronomy impasse
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
The hunt for drugs for mild COVID: scientists seek to treat those at lower risk
Saima May Sidik
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Bizarre bird could reshape the standard tree of life
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems
Jacob Bobonis
; Karin Mitosch; André Mateus; Nicolai Karcher; George Kritikos; Joel Selkrig; Matylda Zietek; Vivian Monzon; Birgit Pfalz; Sarela Garcia-Santamarina; Marco Galardini; Anna Sueki; Callie Kobayashi; Frank Stein; Alex Bateman; Georg Zeller; Mikhail M. Savitski; Johanna R. Elfenbein; Helene L. Andrews-Polymenis; Athanasios Typas
Palabras clave: Multidisciplinary.
Pp. No disponible
Archaic chaperone–usher pili self-secrete into superelastic zigzag springs
Natalia Pakharukova; Henri Malmi; Minna Tuittila; Tobias Dahlberg; Debnath Ghosal; Yi-Wei Chang; Si Lhyam Myint; Sari Paavilainen; Stefan David Knight; Urpo Lamminmäki; Bernt Eric Uhlin; Magnus Andersson; Grant Jensen; Anton V. Zavialov
<jats:title>Abstract</jats:title><jats:p>Adhesive pili assembled through the chaperone–usher pathway are hair-like appendages that mediate host tissue colonization and biofilm formation of Gram-negative bacteria<jats:sup>1–3</jats:sup>. Archaic chaperone–usher pathway pili, the most diverse and widespread chaperone–usher pathway adhesins, are promising vaccine and drug targets owing to their prevalence in the most troublesome multidrug-resistant pathogens<jats:sup>1,4,5</jats:sup>. However, their architecture and assembly–secretion process remain unknown. Here, we present the cryo-electron microscopy structure of the prototypical archaic Csu pilus that mediates biofilm formation of <jats:italic>Acinetobacter baumannii</jats:italic>—a notorious multidrug-resistant nosocomial pathogen. In contrast to the thick helical tubes of the classical type 1 and P pili, archaic pili assemble into an ultrathin zigzag architecture secured by an elegant clinch mechanism. The molecular clinch provides the pilus with high mechanical stability as well as superelasticity, a property observed for the first time, to our knowledge, in biomolecules, while enabling a more economical and faster pilus production. Furthermore, we demonstrate that clinch formation at the cell surface drives pilus secretion through the outer membrane. These findings suggest that clinch-formation inhibitors might represent a new strategy to fight multidrug-resistant bacterial infections.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: ‘No shame in an honest retraction’
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
‘I feel disposable’: Thousands of scientists’ jobs at risk in Japan
Tim Hornyak
Palabras clave: Multidisciplinary.
Pp. No disponible