Catálogo de publicaciones - revistas

<jats:title> <jats:italic>Salmonella</jats:italic> Stealth Bomber </jats:title> <jats:p> <jats:italic>Salmonella</jats:italic> secretes a virulence factor, SipA, which helps it to invade epithelial cells of the gut. During invasion, the host cell is triggered into synthesizing and secreting the apoptotic enzyme caspase-3. <jats:bold> Srikanth <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="390" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1194598">390</jats:related-article> ) now show that instead of being extinguished as the host cell collapses into programmed cell death, during the early stages of infection, <jats:italic>Salmonella</jats:italic> diverts the host enzyme to its own use. The SipA protein has amino acid motifs that are recognized by caspase-3, which cleaves the bacterial protein into active virulence effectors: one stimulates actin polymerization to help cell entry and the other induces inflammation. If the caspase motif contains a single-point mutation, then virulence is lost in mouse models of infection. Conversely, caspase-deficient mice suffer less from <jats:italic>Salmonella</jats:italic> -induced gastroenteritis. </jats:p>

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