Catálogo de publicaciones - revistas

<jats:p>Temperature changes synchronize circadian clocks in organs that can't sense light-dark cycles.</jats:p>

<jats:p>Detailed “fitness landscapes” could reveal the paths for evolution of function.</jats:p>

<jats:p>Bilingual rearing of children, instead of confusing them, may bring lifelong advantages.</jats:p>

<jats:p>Highly complex metal alloy phases have been replicated at a larger scale with spherical aggregates formed from polymers.</jats:p>

<jats:p>Testing not only evaluates the state of memory, but also improves memory more than restudy.</jats:p>

<jats:p>A mutation that changes the specificity of an enzyme in human cancer is also found in an inherited metabolic disorder.</jats:p>

<jats:title>Taking the Cystine</jats:title> <jats:p> Kidney stones that form from <jats:sc>l</jats:sc> -cystine are much less common than those forming from calcium oxalate monohydrate, but are more likely to cause chronic kidney disease. <jats:bold> Rimer <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="337" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1191968">337</jats:related-article> ; see the cover; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6002" page="325" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1197207">Coe and Asplin</jats:related-article> </jats:bold> ) designed two structural mimics for <jats:sc>l</jats:sc> -cystine. Atomic force microscopy showed that at low concentrations, the mimics could change the <jats:sc>l</jats:sc> -cystine crystal habit and inhibit overall crystal growth. These structural mimics may thus offer hope for treating cystinuria. </jats:p>

<jats:title>Following Folding Fast</jats:title> <jats:p> Many protein functions involve conformational changes that occur on time-scales between tens of microseconds and milliseconds. This has limited the usefulness of all-atom molecular dynamics simulations, which are performed over shorter time-scales. <jats:bold> Shaw <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="341" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1187409">341</jats:related-article> ) now report millisecond-scale, all-atom molecular dynamics simulations in an explicitly represented solvent environment. Simulation of the folding of a WW domain showed a well-defined folding pathway and simulation of the dynamics of bovine pancreatic trypsin inhibitor showed interconversion between distinct conformational states. </jats:p>

<jats:title>Shocking Radio Relic</jats:title> <jats:p> Radio relics are diffuse, elongated radio sources located on the outskirts of galaxy clusters thought to trace shocks generated by collisions between galaxy clusters. Particles may be accelerated within the shock waves by a diffusive shock acceleration mechanism, which also accelerates particles in shock waves produced by supernova explosions. <jats:bold> Van Weeren <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="347" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1194293">347</jats:related-article> , published online 23 September) report the detection of a megaparsec-scale radio relic showing all the properties of diffusive shock acceleration expected at radio wavelengths. The results suggest that this acceleration mechanism operates on scales larger than those of supernova remnants and imply that merging clusters of galaxies can accelerate particles to energies much higher than those achieved in supernova remnants </jats:p>

<jats:title>Block Copolymer Assembly</jats:title> <jats:p> Despite their structural simplicity, block copolymers can assemble into complex and often surprising structures. <jats:bold> Lee <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="349" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1195552">349</jats:related-article> ; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6002" page="333" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1196698">Peterca and Percec</jats:related-article> </jats:bold> ) demonstrate the formation of a new ordered phase in a diblock copolymer and a tetrablock copolymer formed from frustrated self-assembled spherical microdomains. Remarkably, this structure contains tetragonal unit cells with 30 spheres per lattice site and is related to dodecagonal quasicrystals. This structure was first described by Frank and Kasper as a sigma phase 50 years ago and is seen in some metal alloys. </jats:p>