Catálogo de publicaciones - revistas

<jats:p>Extreme flooding and droughts may be the new norm for the Amazon, challenging its people and ecosystems</jats:p>

<jats:p>Across Africa, vast areas of nonforest are threatened by inappropriate restoration in the form of tree planting</jats:p>

<jats:p>Cure strategies are confounded by basic reservoir biology</jats:p>

<jats:p>Autoantibodies influence a wide range of conditions beyond autoimmune diseases</jats:p>

<jats:p>Plants commandeer a pathogen’s virulence factor to bolster immunity</jats:p>

<jats:p>A political scientist urges readers to embrace the chaos and complexity of life</jats:p>

<jats:p>How B cells assess risk in the intestine</jats:p>

<jats:p>Epitope editing can empower targeted cancer immunotherapies</jats:p>

<jats:p> We report the design conception, chemical synthesis, and microbiological evaluation of the bridged macrobicyclic antibiotic cresomycin (CRM), which overcomes evolutionarily diverse forms of antimicrobial resistance that render modern antibiotics ineffective. CRM exhibits in vitro and in vivo efficacy against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains of <jats:italic>Staphylococcus aureus</jats:italic> , <jats:italic>Escherichia coli</jats:italic> , and <jats:italic>Pseudomonas aeruginosa</jats:italic> . We show that CRM is highly preorganized for ribosomal binding by determining its density functional theory–calculated, solution-state, solid-state, and (wild-type) ribosome-bound structures, which all align identically within the macrobicyclic subunits. Lastly, we report two additional x-ray crystal structures of CRM in complex with bacterial ribosomes separately modified by the ribosomal RNA methylases, chloramphenicol-florfenicol resistance (Cfr) and erythromycin-resistance ribosomal RNA methylase (Erm), revealing concessive adjustments by the target and antibiotic that permit CRM to maintain binding where other antibiotics fail. </jats:p>