Catálogo de publicaciones - revistas

<jats:p>Flaring is widely used by the fossil fuel industry to dispose of natural gas. Industry and governments generally assume that flares remain lit and destroy methane, the predominant component of natural gas, with 98% efficiency. Neither assumption, however, is based on real-world observations. We calculate flare efficiency using airborne sampling across three basins responsible for &gt;80% of US flaring and combine these observations with unlit flare prevalence surveys. We find that both unlit flares and inefficient combustion contribute comparably to ineffective methane destruction, with flares effectively destroying only 91.1% (90.2, 91.8; 95% confidence interval) of methane. This represents a fivefold increase in methane emissions above present assumptions and constitutes 4 to 10% of total US oil and gas methane emissions, highlighting a previously underappreciated methane source and mitigation opportunity.</jats:p>

<jats:p>Mammalian cells can generate amino acids through macropinocytosis and lysosomal breakdown of extracellular proteins, which is exploited by cancer cells to grow in nutrient-poor tumors. Through genetic screens in defined nutrient conditions, we characterized LYSET, a transmembrane protein (TMEM251) selectively required when cells consume extracellular proteins. LYSET was found to associate in the Golgi with GlcNAc-1-phosphotransferase, which targets catabolic enzymes to lysosomes through mannose-6-phosphate modification. Without LYSET, GlcNAc-1-phosphotransferase was unstable because of a hydrophilic transmembrane domain. Consequently, LYSET-deficient cells were depleted of lysosomal enzymes and impaired in turnover of macropinocytic and autophagic cargoes. Thus, LYSET represents a core component of the lysosomal enzyme trafficking pathway, underlies the pathomechanism for hereditary lysosomal storage disorders, and may represent a target to suppress metabolic adaptations in cancer.</jats:p>

<jats:p>Observers study debris from DART’s crash into a space rock and wait to see how much the asteroid was deflected</jats:p>

<jats:p>In a first for Europe, country borrows concept from Indigenous science to protect endangered body of water</jats:p>

<jats:p>New CHIPS law mandates tougher enforcement of research security by U.S. funding agencies</jats:p>

<jats:p>With rigorous science and good-humored braggadocio, Tulio de Oliveira champions coronavirus research from the Global South</jats:p>

<jats:p>Inactive spores integrate stimuli over time through stored electrochemical potential</jats:p>

<jats:p>Machine learning narrows down the enormous search space for functional materials</jats:p>