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Nature

Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.
Palabras clave – provistas por la editorial

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 2012 / hasta dic. 2023 Nature.com
No detectada desde jul. 2006 / hasta ago. 2012 Ovid

Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Tabla de contenidos

Author Correction: CD201+ fascia progenitors choreograph injury repair

Donovan Correa-Gallegos; Haifeng YeORCID; Bikram Dasgupta; Aydan Sardogan; Safwen Kadri; Ravinder Kandi; Ruoxuan Dai; Yue Lin; Robert Kopplin; Disha Shantaram Shenai; Juliane Wannemacher; Ryo IchijoORCID; Dongsheng Jiang; Maximilian Strunz; Meshal Ansari; Illias Angelidis; Herbert B. SchillerORCID; Thomas Volz; Hans-Günther Machens; Yuval RinkevichORCID

Palabras clave: Multidisciplinary.

Pp. No disponible

Dictionary of immune responses to cytokines at single-cell resolution

Ang CuiORCID; Teddy Huang; Shuqiang LiORCID; Aileen MaORCID; Jorge L. PérezORCID; Chris SanderORCID; Derin B. Keskin; Catherine J. WuORCID; Ernest FraenkelORCID; Nir HacohenORCID

<jats:title>Abstract</jats:title><jats:p>Cytokines mediate cell–cell communication in the immune system and represent important therapeutic targets<jats:sup>1–3</jats:sup>. A myriad of studies have highlighted their central role in immune function<jats:sup>4–13</jats:sup>, yet we lack a global view of the cellular responses of each immune cell type to each cytokine. To address this gap, we created the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (&gt;1,400 cytokine–cell type combinations) in mouse lymph nodes in vivo. A cytokine-centric view of the dictionary revealed that most cytokines induce highly cell-type-specific responses. For example, the inflammatory cytokine interleukin-1β induces distinct gene programmes in almost every cell type. A cell-type-centric view of the dictionary identified more than 66 cytokine-driven cellular polarization states across immune cell types, including previously uncharacterized states such as an interleukin-18-induced polyfunctional natural killer cell state. Based on this dictionary, we developed companion software, Immune Response Enrichment Analysis, for assessing cytokine activities and immune cell polarization from gene expression data, and applied it to reveal cytokine networks in tumours following immune checkpoint blockade therapy. Our dictionary generates new hypotheses for cytokine functions, illuminates pleiotropic effects of cytokines, expands our knowledge of activation states of each immune cell type, and provides a framework to deduce the roles of specific cytokines and cell–cell communication networks in any immune response.</jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

This bird escaped extinction — but its genes hint at an ominous future

Palabras clave: Multidisciplinary.

Pp. No disponible

Logical quantum processor based on reconfigurable atom arrays

Dolev BluvsteinORCID; Simon J. EveredORCID; Alexandra A. GeimORCID; Sophie H. Li; Hengyun ZhouORCID; Tom ManovitzORCID; Sepehr Ebadi; Madelyn CainORCID; Marcin KalinowskiORCID; Dominik HangleiterORCID; J. Pablo Bonilla Ataides; Nishad MaskaraORCID; Iris CongORCID; Xun Gao; Pedro Sales RodriguezORCID; Thomas Karolyshyn; Giulia Semeghini; Michael J. GullansORCID; Markus GreinerORCID; Vladan VuletićORCID; Mikhail D. LukinORCID

Palabras clave: Multidisciplinary.

Pp. No disponible

Catastrophic change looms as Earth nears climate ‘tipping points’, report says

Jeff Tollefson

Palabras clave: Multidisciplinary.

Pp. No disponible

US agency launches experiments to find innovative ways to fund research

Dalmeet Singh Chawla

Palabras clave: Multidisciplinary.

Pp. No disponible

A human embryonic limb cell atlas resolved in space and time

Bao ZhangORCID; Peng HeORCID; John E. G. Lawrence; Shuaiyu Wang; Elizabeth Tuck; Brian A. WilliamsORCID; Kenny RobertsORCID; Vitalii Kleshchevnikov; Lira Mamanova; Liam BoltORCID; Krzysztof PolanskiORCID; Tong LiORCID; Rasa ElmentaiteORCID; Eirini S. Fasouli; Martin PreteORCID; Xiaoling He; Nadav Yayon; Yixi Fu; Hao Yang; Chen Liang; Hui ZhangORCID; Raphael BlainORCID; Alain ChedotalORCID; David R. FitzPatrick; Helen Firth; Andrew Dean; Omer Ali BayraktarORCID; John C. MarioniORCID; Roger A. Barker; Mekayla A. Storer; Barbara J. WoldORCID; Hongbo ZhangORCID; Sarah A. TeichmannORCID

<jats:title>Abstract</jats:title><jats:p>Human limbs emerge during the fourth post-conception week as mesenchymal buds, which develop into fully formed limbs over the subsequent months<jats:sup>1</jats:sup>. This process is orchestrated by numerous temporally and spatially restricted gene expression programmes, making congenital alterations in phenotype common<jats:sup>2</jats:sup>. Decades of work with model organisms have defined the fundamental mechanisms underlying vertebrate limb development, but an in-depth characterization of this process in humans has yet to be performed. Here we detail human embryonic limb development across space and time using single-cell and spatial transcriptomics. We demonstrate extensive diversification of cells from a few multipotent progenitors to myriad differentiated cell states, including several novel cell populations. We uncover two waves of human muscle development, each characterized by different cell states regulated by separate gene expression programmes, and identify musculin (MSC) as a key transcriptional repressor maintaining muscle stem cell identity. Through assembly of multiple anatomically continuous spatial transcriptomic samples using VisiumStitcher, we map cells across a sagittal section of a whole fetal hindlimb. We reveal a clear anatomical segregation between genes linked to brachydactyly and polysyndactyly, and uncover transcriptionally and spatially distinct populations of the mesenchyme in the autopod. Finally, we perform single-cell RNA sequencing on mouse embryonic limbs to facilitate cross-species developmental comparison, finding substantial homology between the two species.</jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

Nomad

Richard A. Lovett

Palabras clave: Multidisciplinary.

Pp. No disponible

Frugal innovation: why low cost doesn’t have to mean low impact

Palabras clave: Multidisciplinary.

Pp. 8-8

Humanity’s oldest art is flaking away. Can scientists save it?

Dyani Lewis

Palabras clave: Multidisciplinary.

Pp. 26-30