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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
The oldest three-dimensionally preserved vertebrate neurocranium
Richard P. Dearden
; Agnese Lanzetti; Sam Giles; Zerina Johanson; Andy S. Jones; Stephan Lautenschlager; Emma Randle; Ivan J. Sansom
<jats:title>Abstract</jats:title><jats:p>The neurocranium is an integral part of the vertebrate head, itself a major evolutionary innovation<jats:sup>1,2</jats:sup>. However, its early history remains poorly understood, with great dissimilarity in form between the two living vertebrate groups: gnathostomes (jawed vertebrates) and cyclostomes (hagfishes and lampreys)<jats:sup>2,3</jats:sup>. The 100 Myr gap separating the Cambrian appearance of vertebrates<jats:sup>4–6</jats:sup> from the earliest three-dimensionally preserved vertebrate neurocrania<jats:sup>7</jats:sup> further obscures the origins of modern states. Here we use computed tomography to describe the cranial anatomy of an Ordovician stem-group gnathostome: <jats:italic>Eriptychius americanus</jats:italic> from the Harding Sandstone of Colorado, USA<jats:sup>8</jats:sup>. A fossilized head of <jats:italic>Eriptychius</jats:italic> preserves a symmetrical set of cartilages that we interpret as the preorbital neurocranium, enclosing the fronts of laterally placed orbits, terminally located mouth, olfactory bulbs and pineal organ. This suggests that, in the earliest gnathostomes, the neurocranium filled out the space between the dermal skeleton and brain, like in galeaspids, osteostracans and placoderms and unlike in cyclostomes<jats:sup>2</jats:sup>. However, these cartilages are not fused into a single neurocranial unit, suggesting that this is a derived gnathostome trait. <jats:italic>Eriptychius</jats:italic> fills a major temporal and phylogenetic gap in our understanding of the evolution of the gnathostome head, revealing a neurocranium with an anatomy unlike that of any previously described vertebrate.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Synthesis of portimines reveals the basis of their anti-cancer activity
Junchen Tang; Weichao Li; Tzu-Yuan Chiu; Francisco Martínez-Peña; Zengwei Luo; Christine T. Chong; Qijia Wei; Nathalia Gazaniga; Thomas J. West; Yi Yang See; Luke L. Lairson; Christopher G. Parker; Phil S. Baran
Palabras clave: Multidisciplinary.
Pp. No disponible
The UK’s post-Brexit EU science deal: a graphical guide
Lilly Tozer; Katharine Sanderson; Nisha Gaind; Layal Liverpool; Miryam Naddaf; Emma Stoye
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: World’s most powerful X-ray laser will ‘film’ electrical charges hopping around atoms
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
Would you still love me if I was a wormhole?
Wendy Nikel
Palabras clave: Multidisciplinary.
Pp. No disponible
Global iron and steel plant CO2 emissions and carbon-neutrality pathways
Tianyang Lei; Daoping Wang; Xiang Yu; Shijun Ma; Weichen Zhao; Can Cui; Jing Meng; Shu Tao; Dabo Guan
Palabras clave: Multidisciplinary.
Pp. No disponible
Acetyl-methyllysine marks chromatin at active transcription start sites
William J. Lu-Culligan; Leah J. Connor; Yixuan Xie; Babatunde E. Ekundayo; Brendan T. Rose; Martin Machyna; Andreas P. Pintado-Urbanc; Joshua T. Zimmer; Isaac W. Vock; Natarajan V. Bhanu; Megan C. King; Benjamin A. Garcia; Franziska Bleichert; Matthew D. Simon
Palabras clave: Multidisciplinary.
Pp. No disponible
Cingulate dynamics track depression recovery with deep brain stimulation
Sankaraleengam Alagapan; Ki Sueng Choi; Stephen Heisig; Patricio Riva-Posse; Andrea Crowell; Vineet Tiruvadi; Mosadoluwa Obatusin; Ashan Veerakumar; Allison C. Waters; Robert E. Gross; Sinead Quinn; Lydia Denison; Matthew O’Shaughnessy; Marissa Connor; Gregory Canal; Jungho Cha; Rachel Hershenberg; Tanya Nauvel; Faical Isbaine; Muhammad Furqan Afzal; Martijn Figee; Brian H. Kopell; Robert Butera; Helen S. Mayberg; Christopher J. Rozell
<jats:title>Abstract</jats:title><jats:p>Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD)<jats:sup>1</jats:sup>. However, achieving stable recovery is unpredictable<jats:sup>2</jats:sup>, typically requiring trial-and-error stimulation adjustments due to individual recovery trajectories and subjective symptom reporting<jats:sup>3</jats:sup>. We currently lack objective brain-based biomarkers to guide clinical decisions by distinguishing natural transient mood fluctuations from situations requiring intervention. To address this gap, we used a new device enabling electrophysiology recording to deliver SCC DBS to ten TRD participants (ClinicalTrials.gov identifier NCT01984710). At the study endpoint of 24 weeks, 90% of participants demonstrated robust clinical response, and 70% achieved remission. Using SCC local field potentials available from six participants, we deployed an explainable artificial intelligence approach to identify SCC local field potential changes indicating the patient’s current clinical state. This biomarker is distinct from transient stimulation effects, sensitive to therapeutic adjustments and accurate at capturing individual recovery states. Variable recovery trajectories are predicted by the degree of preoperative damage to the structural integrity and functional connectivity within the targeted white matter treatment network, and are matched by objective facial expression changes detected using data-driven video analysis. Our results demonstrate the utility of objective biomarkers in the management of personalized SCC DBS and provide new insight into the relationship between multifaceted (functional, anatomical and behavioural) features of TRD pathology, motivating further research into causes of variability in depression treatment.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
Anna-Maria Globig; Steven Zhao; Jessica Roginsky; Vivien I. Maltez; Juan Guiza; Natalia Avina-Ochoa; Maximilian Heeg; Filipe Araujo Hoffmann; Omkar Chaudhary; Jiawei Wang; Gokhan Senturk; Dan Chen; Carolyn O’Connor; Samuel Pfaff; Ronald N. Germain; Kurt A. Schalper; Brinda Emu; Susan M. Kaech
Palabras clave: Multidisciplinary.
Pp. No disponible
Neural circuitry for maternal oxytocin release induced by infant cries
Silvana Valtcheva; Habon A. Issa; Chloe J. Bair-Marshall; Kathleen A. Martin; Kanghoon Jung; Yiyao Zhang; Hyung-Bae Kwon; Robert C. Froemke
Palabras clave: Multidisciplinary.
Pp. No disponible