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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
African scientists call for research equity as a cancer crisis looms
Linda Nordling
Palabras clave: Multidisciplinary.
Pp. S16-S17
Melaku Worede, crop genetics leader (1936–2023)
Palabras clave: Multidisciplinary.
Pp. 33-33
With the arrival of El Niño, prepare for stronger marine heatwaves
Alistair J. Hobday; Michael T. Burrows; Karen Filbee-Dexter; Neil J. Holbrook; Alex Sen Gupta; Dan A. Smale; Kathryn E. Smith; Mads S. Thomsen; Thomas Wernberg
Palabras clave: Multidisciplinary.
Pp. 38-41
Surface interaction propels molecule forwards
Leo Gross; Jascha Repp
Palabras clave: Multidisciplinary.
Pp. 49-50
Visualizing interfacial collective reaction behaviour of Li–S batteries
Shiyuan Zhou
; Jie Shi; Sangui Liu; Gen Li; Fei Pei; Youhu Chen; Junxian Deng; Qizheng Zheng; Jiayi Li; Chen Zhao; Inhui Hwang; Cheng-Jun Sun; Yuzi Liu; Yu Deng; Ling Huang; Yu Qiao; Gui-Liang Xu; Jian-Feng Chen; Khalil Amine; Shi-Gang Sun; Hong-Gang Liao
Palabras clave: Multidisciplinary.
Pp. 75-81
How we set our lab on an environmentally sustainable path
Caroline Giuglaris
Palabras clave: Multidisciplinary.
Pp. 215-216
Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology
Chang Sun; Hongtao Zhu; Sarah Clark; Eric Gouaux
<jats:title>Abstract</jats:title><jats:p>Type A γ-aminobutyric acid receptors (GABA<jats:sub>A</jats:sub>Rs) are the principal inhibitory receptors in the brain and the target of a wide range of clinical agents, including anaesthetics, sedatives, hypnotics and antidepressants<jats:sup>1–3</jats:sup>. However, our understanding of GABA<jats:sub>A</jats:sub>R pharmacology has been hindered by the vast number of pentameric assemblies that can be derived from 19 different subunits<jats:sup>4</jats:sup> and the lack of structural knowledge of clinically relevant receptors. Here, we isolate native murine GABA<jats:sub>A</jats:sub>R assemblies containing the widely expressed α1 subunit and elucidate their structures in complex with drugs used to treat insomnia (zolpidem (ZOL) and flurazepam) and postpartum depression (the neurosteroid allopregnanolone (APG)). Using cryo-electron microscopy (cryo-EM) analysis and single-molecule photobleaching experiments, we uncover three major structural populations in the brain: the canonical α1β2γ2 receptor containing two α1 subunits, and two assemblies containing one α1 and either an α2 or α3 subunit, in which the single α1-containing receptors feature a more compact arrangement between the transmembrane and extracellular domains. Interestingly, APG is bound at the transmembrane α/β subunit interface, even when not added to the sample, revealing an important role for endogenous neurosteroids in modulating native GABA<jats:sub>A</jats:sub>Rs. Together with structurally engaged lipids, neurosteroids produce global conformational changes throughout the receptor that modify the ion channel pore and the binding sites for GABA and insomnia medications. Our data reveal the major α1-containing GABA<jats:sub>A</jats:sub>R assemblies, bound with endogenous neurosteroid, thus defining a structural landscape from which subtype-specific drugs can be developed.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
‘They went to the bar at noon’: what this virtual AI village is teaching researchers
Palabras clave: Multidisciplinary.
Pp. No disponible
Changing old viticulture for all the right rieslings
Rachel Nuwer
Palabras clave: Multidisciplinary.
Pp. No disponible
The chemical synthesis and anti-cancer properties of portimines
Palabras clave: Multidisciplinary.
Pp. No disponible