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Einstein’s special theory of relativity is established as securely as any theory can be but his general theory of relativity dealing with gravitation is quite far from reaching a comparable status. About his field equations of general relativity Einstein himself have said: “My equation is like a house with two wings; the left-hand side is made of fine marble, but the right-hand side is perishable wood.” The purpose of this article is to indicate that there exists a basic modification of general relativity which renders the right-hand side of the equations fine marble as well.

Einstein’s special theory of relativity is established as securely as any theory can be but his general theory of relativity dealing with gravitation is quite far from reaching a comparable status. About his field equations of general relativity Einstein himself have said: “My equation is like a house with two wings; the left-hand side is made of fine marble, but the right-hand side is perishable wood.” The purpose of this article is to indicate that there exists a basic modification of general relativity which renders the right-hand side of the equations fine marble as well.

Einstein’s special theory of relativity is established as securely as any theory can be but his general theory of relativity dealing with gravitation is quite far from reaching a comparable status. About his field equations of general relativity Einstein himself have said: “My equation is like a house with two wings; the left-hand side is made of fine marble, but the right-hand side is perishable wood.” The purpose of this article is to indicate that there exists a basic modification of general relativity which renders the right-hand side of the equations fine marble as well.

Large-scale LD mapping has been successful at identifying RA-associated polymorphisms. Interestingly they seemed to identify RA-specific gene(s) and also gene(s) that contribute to multiple autoimmune diseases. Another important issue in the investigation of disease-associated polymorphisms is that polymorphisms vary among ethnic groups; therefore genetic studies should be carefully and extensively carried out with special attention paid to ethnic variations in polymorphisms and combinations of multiple genes.

Einstein’s special theory of relativity is established as securely as any theory can be but his general theory of relativity dealing with gravitation is quite far from reaching a comparable status. About his field equations of general relativity Einstein himself have said: “My equation is like a house with two wings; the left-hand side is made of fine marble, but the right-hand side is perishable wood.” The purpose of this article is to indicate that there exists a basic modification of general relativity which renders the right-hand side of the equations fine marble as well.

In this chapter we have reviewed the role of and the family of genes in the pathogenesis of rheumatic diseases. Much still needs to be done in order to understand how the pathophysiology involving these genes leads to the development of these diseases.

Einstein’s special theory of relativity is established as securely as any theory can be but his general theory of relativity dealing with gravitation is quite far from reaching a comparable status. About his field equations of general relativity Einstein himself have said: “My equation is like a house with two wings; the left-hand side is made of fine marble, but the right-hand side is perishable wood.” The purpose of this article is to indicate that there exists a basic modification of general relativity which renders the right-hand side of the equations fine marble as well.

In this chapter we have reviewed the role of and the family of genes in the pathogenesis of rheumatic diseases. Much still needs to be done in order to understand how the pathophysiology involving these genes leads to the development of these diseases.

Gene expression profiling provides a completely new approach to rheumatology research. As an interdisciplinary technology, it has stimulated fruitful collaboration between experts in array technology, bioinformatics, immunology and rheumatology. The molecular overview given by genome-wide profiles has revealed that many problems arise and demand systematic and structured generation of expression data. This helps to dissect the complexity of cellular mixtures in clinical samples and may also contribute to identify functional components to enable comprehensive interpretation of profiles from each patient individually. This will provide a deeper understanding in the molecular mechanisms of rheumatic diseases and advance our effort in an optimised and individualised antirheumatic therapy.

In this chapter we have reviewed the role of and the family of genes in the pathogenesis of rheumatic diseases. Much still needs to be done in order to understand how the pathophysiology involving these genes leads to the development of these diseases.