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Biochemical Pharmacology

Resumen/Descripción – provisto por la editorial en inglés
Biochemical Pharmacology publishes original research findings, Commentaries and review articles related to the elucidation of cellular and tissue function(s) at the biochemical and molecular levels, the modification of cellular phenotype(s) by genetic, transcriptional/translational or drug/compound-induced modifications, as well as the pharmacodynamics and pharmacokinetics of xenobiotics and drugs, the latter including both small molecules and biologics.

The journal's target audience includes scientists engaged in the identification and study of the mechanisms of action of xenobiotics, biologics and drugs and in the drug discovery and development process.

All areas of cellular biology and cellular, tissue/organ and whole animal pharmacology fall within the scope of the journal. Drug classes covered include anti-infectives, anti-inflammatory agents, chemotherapeutics, cardiovascular, endocrinological, immunological, metabolic, neurological and psychiatric drugs, as well as research on drug metabolism and kinetics. While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Submissions describing work focused predominately on chemical synthesis and molecular modeling will not be considered for review.

While particular emphasis is placed on reporting the results of molecular and biochemical studies, research involving the use of tissue and animal models of human pathophysiology and toxicology is of interest to the extent that it helps define drug mechanisms of action, safety and efficacy.

Reports describing experiments conducted with natural product mixtures, plant or animal extracts will not be considered for publication unless the structures and concentrations of all component substances are known, and the agents can be easily obtained by others wishing to replicate the study.

The chemical structure of all novel compounds tested must be included in the submitted manuscript or be readily accessible in the published literature. References to structures in the patent literature must unambiguously identify a single molecular structure. All compounds, reagents, instrumentation and equipment employed in a study must be available from identified commercial suppliers, bio/pharmaceutical companies or from individuals holding legal rights to their use. Submissions will not be considered for publication if the chemical structures of tested compounds are not revealed, generally known, or accessible in the literature.

Original research submissions must contain:A rationale for the selection of the compound/drug for study as well as for the concentrations/doses employed. Quantities used for concentration- and dose-response experiments should vary logarithmically, e.g., 1, 3, 10, 30 mg/kg, 0.1, 1.0, 10, 100 nanomolar, etc. Justification must be provided for studying only a single concentration or dose of a compound, especially as it relates to reference standards and antagonists/modulators of receptors, enzymes and signaling pathways. Justification must also be provided for the selection of the statistical tests employed as they relate to the experimental design. It is expected that all findings have been subjected to rigorous quantitative analyses, with the calculation and reporting of IC50, Ki, EC50, etc., values. These must be derived from a minimum of three (3) separate and distinct experiments, with the replicates within any single experiment being averaged to obtain a single value for that experimental series. Manuscripts that fail to meet these criteria will be subject to rejection without peer-review. US National Institutes of Health (NIH) voluntary posting (""Public Access"") policy
Biochemical Pharmacology and Elsevier facilitate the author's response to the NIH Public Access Policy.

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Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 1958 / hasta dic. 2023 ScienceDirect

Información

Tipo de recurso:

revistas

ISSN impreso

0006-2952

ISSN electrónico

1873-2968

Editor responsable

Elsevier

País de edición

Países Bajos

Fecha de publicación

Cobertura temática

medicina-basica

Medicina básica

Tabla de contenidos

doi: 10.1016/0006-2952(82)90295-7

Studies on the mechanism of phospholipid storage induced by amantadine and chloroquine in Madin Darby canine kidney cells

Karl Y. Hostetler; Douglas D. Richman

Palabras clave: Biochemistry; Pharmacology.

Pp. 3795-3799

doi: 10.1016/0006-2952(90)90178-n

Structure and dynamics in proteins of pharmacological interest

Kurt Wüthrich

Palabras clave: Biochemistry; Pharmacology.

Pp. 55-62

doi: 10.1016/j.bcp.2006.09.022

Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series)

Denis S. Theobald; Hans H. Maurer

Palabras clave: Biochemistry; Pharmacology.

Pp. 287-297

doi: 10.1016/j.bcp.2021.114433

Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways

Eva Florensa-Zanuy; Emilio Garro-Martínez; Albert Adell; Elena Castro; Álvaro Díaz; Ángel Pazos; Karina S. Mac-Dowell; David Martín-Hernández; Fuencisla Pilar-Cuéllar

Palabras clave: Pharmacology; Biochemistry.

Pp. 114433

doi: 10.1016/j.bcp.2023.115918

Antidepressant mechanisms of ketamine’s action: NF-κB in the spotlight

Paulina Sokołowska; Michał Seweryn Karbownik; Marta Jóźwiak-Bębenista; Maria Dobielska; Edward Kowalczyk; Anna Wiktorowska-Owczarek

Palabras clave: Pharmacology; Biochemistry.

Pp. 115918