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Toxicology and Applied Pharmacology

Resumen/Descripción – provisto por la editorial en inglés
Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products.

Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged.

Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.

TAAP also issues a standing call for outstanding Invited Review Articles. Potential authors should contact the Editor-In-Chief and complete an Invited Review Proposal Form before preparing or submitting their Review Article.

Benefits to authors
We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .

Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our support pages: http://support.elsevier.com
Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde ene. 1959 / hasta dic. 2023 ScienceDirect

Información

Tipo de recurso:

revistas

ISSN impreso

0041-008X

ISSN electrónico

1096-0333

Editor responsable

Elsevier

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

In silico toxicology for the pharmaceutical sciences☆

Luis G. Valerio Jr.

Palabras clave: Toxicology; Pharmacology.

Pp. 356-370

In silico modeling to predict drug-induced phospholipidosis

Sydney S. Choi; Jae S. Kim; Luis G. Valerio; Nakissa Sadrieh

Palabras clave: Toxicology; Pharmacology.

Pp. 195-204

The proteasome inhibitor bortezomib induces testicular toxicity by upregulation of oxidative stress, AMP-activated protein kinase (AMPK) activation and deregulation of germ cell development in adult murine testis

Wei Li; Jianfang Fu; Shun Zhang; Jie Zhao; Nianlin Xie; Guoqing Cai

Palabras clave: Toxicology; Pharmacology.

Pp. 98-109

Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis

Flavia Lambertucci; Omar Motiño; Silvina Villar; Juan Pablo Rigalli; María de Luján Alvarez; Viviana A Catania; Paloma Martín-Sanz; Cristina Ester Carnovale; Ariel Darío Quiroga; Daniel Eleazar Francés; María Teresa Ronco

Palabras clave: Pharmacology; Toxicology.

Pp. 12-22

The monoamine oxidase inhibition properties of selected structural analogues of methylene blue

Anzelle Delport; Brian H. Harvey; Anél Petzer; Jacobus P. PetzerORCID

Pp. 1-8