Catálogo de publicaciones - revistas
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis
Resumen/Descripción – provisto por la editorial en inglés
Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis provides a platform for publishing all aspects of DNA mutations and epimutations, from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization, from point mutations to genome structural variation, chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome, i.e., changes in DNA methylation, histone modification and small regulatory RNAs. We are interested in: mechanisms of (epi)mutation induction, for example, during DNA repair, replication or recombination; novel methods of (epi)mutation detection, with a focus on ultra-high-throughput sequencing; the landscape of somatic mutations and epimutations in cancer and aging; the role of de novo mutations in human disease and aging; mutations in population genomics; interactions between mutations and epimutations; the role of epimutations in chromatin structure and function; mitochondrial DNA mutations and their consequences in terms of human disease and aging; and novel ways to generate mutations and epimutations in cell lines and animal models. Of special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation, stem cell biology and cell fate in general, including various forms of cell death and cellular senescence. The study of genome instability in human molecular epidemiology and in relation to complex phenotypes, such as human disease, is considered a growing area of importance.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde may. 1964 / hasta dic. 2023 | ScienceDirect |
Información
Tipo de recurso:
revistas
ISSN impreso
0027-5107
ISSN electrónico
1873-135X
Editor responsable
Elsevier
País de edición
Países Bajos
Fecha de publicación
1964-
Cobertura temática
Tabla de contenidos
Verificá que desde tu institución tengas acceso para descargar o
solicitar el libro completo o alguno de sus capítulos.
The Ames Salmonella/microsome mutagenicity assay
Kristien Mortelmans; Errol Zeiger
Palabras clave: Genetics; Health, Toxicology and Mutagenesis; Molecular Biology.
Pp. 29-60