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Advances in Targeted Cancer Therapy

Paul L. Herrling ; Alex Matter ; Richard M. Schultz (eds.)

Resumen/Descripción – provisto por la editorial

No disponible.

Palabras clave – provistas por la editorial

Cancer Research; Molecular Medicine

Disponibilidad
Institución detectada Año de publicación Navegá Descargá Solicitá
No detectada 2005 SpringerLink

Información

Tipo de recurso:

libros

ISBN impreso

978-3-7643-7174-6

ISBN electrónico

978-3-7643-7414-3

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Información sobre derechos de publicación

© Birkhäuser Verlag 2005

Tabla de contenidos

Dawn of a new era in molecular cancer therapeutics

Richard M. Schultz

Semiconductor quantum dots are fascinating objects, since, in some respect, they can be regarded as artificial atoms [1]. Figure 5.1 shows a very schematic comparison of a real three–dimensional atom and a disc–shaped quantum dot. The structure of real atoms is three–dimensional, while most of the artificial quantum dots can be regarded as large Q2D atoms, since the lateral dimensions are in most cases much larger than the vertical extension. Of course, a crucial difference between the two systems is the shape of the confining potentials, which, for real atoms is essentially the Coulomb potential of the nucleus, and, for quantum–dot atoms in some approximation a two–dimensional parabolic potential.

Pp. 1-17

Obtacles and opportunities in the clinical development of targeted therapeutics

Grace K. Dy; Alex A. Adjei

Semiconductor quantum dots are fascinating objects, since, in some respect, they can be regarded as artificial atoms [1]. Figure 5.1 shows a very schematic comparison of a real three–dimensional atom and a disc–shaped quantum dot. The structure of real atoms is three–dimensional, while most of the artificial quantum dots can be regarded as large Q2D atoms, since the lateral dimensions are in most cases much larger than the vertical extension. Of course, a crucial difference between the two systems is the shape of the confining potentials, which, for real atoms is essentially the Coulomb potential of the nucleus, and, for quantum–dot atoms in some approximation a two–dimensional parabolic potential.

Pp. 19-41

Tumor models for preclinical development of targeted agents

Beverly A. Teicher

In conclusion, because of the responses observed in phase I, II and III trials with angiogenesis inhibitors in combination with other biological agents or classic chemotherapy, there is no longer doubt that anti-angiogenic agents have become part of anticancer therapy in general. In the coming years, we should further explore the treatment strategies in which anti-angiogenic agents will add to a prolonged survival and an increase in the cure rate of cancer. In our opinion, the contribution of these agents will be tremendous.

Pp. 43-66

Angiogenesis inhibitors: What is the clinical future?

Henk M. W. Verheul; Herbert M. Pinedo

In conclusion, because of the responses observed in phase I, II and III trials with angiogenesis inhibitors in combination with other biological agents or classic chemotherapy, there is no longer doubt that anti-angiogenic agents have become part of anticancer therapy in general. In the coming years, we should further explore the treatment strategies in which anti-angiogenic agents will add to a prolonged survival and an increase in the cure rate of cancer. In our opinion, the contribution of these agents will be tremendous.

Pp. 67-91

Epidermal growth factor receptor (EGFR) inhibitors in cancer therapy

Fortunato Ciardiello; Ferdinando De Vita

Semiconductor quantum dots are fascinating objects, since, in some respect, they can be regarded as artificial atoms [1]. Figure 5.1 shows a very schematic comparison of a real three–dimensional atom and a disc–shaped quantum dot. The structure of real atoms is three–dimensional, while most of the artificial quantum dots can be regarded as large Q2D atoms, since the lateral dimensions are in most cases much larger than the vertical extension. Of course, a crucial difference between the two systems is the shape of the confining potentials, which, for real atoms is essentially the Coulomb potential of the nucleus, and, for quantum–dot atoms in some approximation a two–dimensional parabolic potential.

Pp. 93-115

Cell survival signaling during apoptosis: Implications in drug resistance and anti-cancer therapeutic development

Grace Choy; Jun-Wei Liu; Dhyan Chandra; Dean G. Tang

In conclusion, because of the responses observed in phase I, II and III trials with angiogenesis inhibitors in combination with other biological agents or classic chemotherapy, there is no longer doubt that anti-angiogenic agents have become part of anticancer therapy in general. In the coming years, we should further explore the treatment strategies in which anti-angiogenic agents will add to a prolonged survival and an increase in the cure rate of cancer. In our opinion, the contribution of these agents will be tremendous.

Pp. 115-145

Targeted histone deacetylase inhibition for cancer prevention and therapy

Carlo Palmieri; R. Charles Coombes; David M. Vigushin

In conclusion, because of the responses observed in phase I, II and III trials with angiogenesis inhibitors in combination with other biological agents or classic chemotherapy, there is no longer doubt that anti-angiogenic agents have become part of anticancer therapy in general. In the coming years, we should further explore the treatment strategies in which anti-angiogenic agents will add to a prolonged survival and an increase in the cure rate of cancer. In our opinion, the contribution of these agents will be tremendous.

Pp. 147-191

Inhibitors of cyclin-dependent kinase modulators for cancer therapy

Adrian M. Senderowicz

In conclusion, because of the responses observed in phase I, II and III trials with angiogenesis inhibitors in combination with other biological agents or classic chemotherapy, there is no longer doubt that anti-angiogenic agents have become part of anticancer therapy in general. In the coming years, we should further explore the treatment strategies in which anti-angiogenic agents will add to a prolonged survival and an increase in the cure rate of cancer. In our opinion, the contribution of these agents will be tremendous.

Pp. 183-206

Targeting cyclooxygenase-2 for cancer prevention and treatment

Stephen T. Gately

Semiconductor quantum dots are fascinating objects, since, in some respect, they can be regarded as artificial atoms [1]. Figure 5.1 shows a very schematic comparison of a real three–dimensional atom and a disc–shaped quantum dot. The structure of real atoms is three–dimensional, while most of the artificial quantum dots can be regarded as large Q2D atoms, since the lateral dimensions are in most cases much larger than the vertical extension. Of course, a crucial difference between the two systems is the shape of the confining potentials, which, for real atoms is essentially the Coulomb potential of the nucleus, and, for quantum–dot atoms in some approximation a two–dimensional parabolic potential.

Pp. 207-225

Antisense approaches in drug discovery and development

Elizabeth Rayburn; Wei Wang; Ruiwen Zhang; Hui Wang

In conclusion, because of the responses observed in phase I, II and III trials with angiogenesis inhibitors in combination with other biological agents or classic chemotherapy, there is no longer doubt that anti-angiogenic agents have become part of anticancer therapy in general. In the coming years, we should further explore the treatment strategies in which anti-angiogenic agents will add to a prolonged survival and an increase in the cure rate of cancer. In our opinion, the contribution of these agents will be tremendous.

Pp. 227-274