Catálogo de publicaciones - libros

In this chapter, the authors attempted to show how considerations of pharmacokinetics and metabolism guide the process of developing drugs with improved delivery characteristics and the ability to target specific organs or tissues so as to maximise therapeutic efficacy. In reviewing some of the main approaches adopted to achieve these ends, we have deliberately omitted detailed chemical methodology, which we consider as secondary to the design concepts. Aspects of the synthetic methodology feature in many of the papers and reviews cited above. Compilation of this modest review owes everything to the eminent scientists whose original, imaginative concepts outlined above have been responsible for the creation of new generations of effective drugs. One message that is implicit in the above review is that due recognition of pharmacokinetic issues and a deeper insight into the nature of drug metabolism will contribute to more successful application of the principles outlined above to the design of new drug molecules.

The major thrust of this monograph has in fact been to elucidate the complex nature of drug metabolism and its ramifications in medicine. In aiming to reflect the richness and vitality of this subject, as well as justify the term ‘current’ in the title of this monograph, we have included many references to various types of studies performed during the last five years and attempted to explain their significance in modern medicine. We trust that the resulting document will cater for a wide readership, ranging from students of pharmacy, chemistry, biochemistry and pharmacology to established professionals in the health sciences.

A considerably detailed treatment of drug-drug interactions and adverse reactions has been presented above, together with older and more recent examples of each. Much of this material relates to known, well-documented cases that are of general interest. However, a crucial aspect of drug-drug interactions and adverse reactions is the possibility of predicting their occurrence for new drug candidates. Some indication as to how this is being addressed by modern methods, including computational approaches, has been given above. The final chapter, dealing with certain aspects of drug design, draws on concepts presented in the previous chapters, the intention being to demonstrate how various aspects of drug metabolism are taken into consideration in deriving new drugs with predictable and controllable biotransformation.

In this chapter, the authors attempted to show how considerations of pharmacokinetics and metabolism guide the process of developing drugs with improved delivery characteristics and the ability to target specific organs or tissues so as to maximise therapeutic efficacy. In reviewing some of the main approaches adopted to achieve these ends, we have deliberately omitted detailed chemical methodology, which we consider as secondary to the design concepts. Aspects of the synthetic methodology feature in many of the papers and reviews cited above. Compilation of this modest review owes everything to the eminent scientists whose original, imaginative concepts outlined above have been responsible for the creation of new generations of effective drugs. One message that is implicit in the above review is that due recognition of pharmacokinetic issues and a deeper insight into the nature of drug metabolism will contribute to more successful application of the principles outlined above to the design of new drug molecules.

The major thrust of this monograph has in fact been to elucidate the complex nature of drug metabolism and its ramifications in medicine. In aiming to reflect the richness and vitality of this subject, as well as justify the term ‘current’ in the title of this monograph, we have included many references to various types of studies performed during the last five years and attempted to explain their significance in modern medicine. We trust that the resulting document will cater for a wide readership, ranging from students of pharmacy, chemistry, biochemistry and pharmacology to established professionals in the health sciences.

In describing above the role and nature of enzymes in the most prominent classes, as well as some aspects of their action at the molecular level, the authors’ intention has in part been to prepare the way for an appreciation of two extremely important phenomena that govern enzyme activity and that have crucial implications for the pharmacological effects of drugs. These are the occurrence of adverse reactions and drug-drug interactions, both of which can be understood on the basis of enzyme induction and enzyme inhibition, the topics of the next chapter.

A considerably detailed treatment of drug-drug interactions and adverse reactions has been presented above, together with older and more recent examples of each. Much of this material relates to known, well-documented cases that are of general interest. However, a crucial aspect of drug-drug interactions and adverse reactions is the possibility of predicting their occurrence for new drug candidates. Some indication as to how this is being addressed by modern methods, including computational approaches, has been given above. The final chapter, dealing with certain aspects of drug design, draws on concepts presented in the previous chapters, the intention being to demonstrate how various aspects of drug metabolism are taken into consideration in deriving new drugs with predictable and controllable biotransformation.

In this chapter, the authors attempted to show how considerations of pharmacokinetics and metabolism guide the process of developing drugs with improved delivery characteristics and the ability to target specific organs or tissues so as to maximise therapeutic efficacy. In reviewing some of the main approaches adopted to achieve these ends, we have deliberately omitted detailed chemical methodology, which we consider as secondary to the design concepts. Aspects of the synthetic methodology feature in many of the papers and reviews cited above. Compilation of this modest review owes everything to the eminent scientists whose original, imaginative concepts outlined above have been responsible for the creation of new generations of effective drugs. One message that is implicit in the above review is that due recognition of pharmacokinetic issues and a deeper insight into the nature of drug metabolism will contribute to more successful application of the principles outlined above to the design of new drug molecules.

The major thrust of this monograph has in fact been to elucidate the complex nature of drug metabolism and its ramifications in medicine. In aiming to reflect the richness and vitality of this subject, as well as justify the term ‘current’ in the title of this monograph, we have included many references to various types of studies performed during the last five years and attempted to explain their significance in modern medicine. We trust that the resulting document will cater for a wide readership, ranging from students of pharmacy, chemistry, biochemistry and pharmacology to established professionals in the health sciences.

In this chapter, the authors attempted to show how considerations of pharmacokinetics and metabolism guide the process of developing drugs with improved delivery characteristics and the ability to target specific organs or tissues so as to maximise therapeutic efficacy. In reviewing some of the main approaches adopted to achieve these ends, we have deliberately omitted detailed chemical methodology, which we consider as secondary to the design concepts. Aspects of the synthetic methodology feature in many of the papers and reviews cited above. Compilation of this modest review owes everything to the eminent scientists whose original, imaginative concepts outlined above have been responsible for the creation of new generations of effective drugs. One message that is implicit in the above review is that due recognition of pharmacokinetic issues and a deeper insight into the nature of drug metabolism will contribute to more successful application of the principles outlined above to the design of new drug molecules.

The major thrust of this monograph has in fact been to elucidate the complex nature of drug metabolism and its ramifications in medicine. In aiming to reflect the richness and vitality of this subject, as well as justify the term ‘current’ in the title of this monograph, we have included many references to various types of studies performed during the last five years and attempted to explain their significance in modern medicine. We trust that the resulting document will cater for a wide readership, ranging from students of pharmacy, chemistry, biochemistry and pharmacology to established professionals in the health sciences.

A considerably detailed treatment of drug-drug interactions and adverse reactions has been presented above, together with older and more recent examples of each. Much of this material relates to known, well-documented cases that are of general interest. However, a crucial aspect of drug-drug interactions and adverse reactions is the possibility of predicting their occurrence for new drug candidates. Some indication as to how this is being addressed by modern methods, including computational approaches, has been given above. The final chapter, dealing with certain aspects of drug design, draws on concepts presented in the previous chapters, the intention being to demonstrate how various aspects of drug metabolism are taken into consideration in deriving new drugs with predictable and controllable biotransformation.

In this chapter, the authors attempted to show how considerations of pharmacokinetics and metabolism guide the process of developing drugs with improved delivery characteristics and the ability to target specific organs or tissues so as to maximise therapeutic efficacy. In reviewing some of the main approaches adopted to achieve these ends, we have deliberately omitted detailed chemical methodology, which we consider as secondary to the design concepts. Aspects of the synthetic methodology feature in many of the papers and reviews cited above. Compilation of this modest review owes everything to the eminent scientists whose original, imaginative concepts outlined above have been responsible for the creation of new generations of effective drugs. One message that is implicit in the above review is that due recognition of pharmacokinetic issues and a deeper insight into the nature of drug metabolism will contribute to more successful application of the principles outlined above to the design of new drug molecules.

The major thrust of this monograph has in fact been to elucidate the complex nature of drug metabolism and its ramifications in medicine. In aiming to reflect the richness and vitality of this subject, as well as justify the term ‘current’ in the title of this monograph, we have included many references to various types of studies performed during the last five years and attempted to explain their significance in modern medicine. We trust that the resulting document will cater for a wide readership, ranging from students of pharmacy, chemistry, biochemistry and pharmacology to established professionals in the health sciences.