Catálogo de publicaciones - libros
Genetic Engineering of Mesenchymal Stem Cells
Jan A. Nolta (eds.)
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
Cell Biology; Biomedicine general; Hematology; Transplant Surgery; Animal Physiology
Disponibilidad
Institución detectada | Año de publicación | Navegá | Descargá | Solicitá |
---|---|---|---|---|
No detectada | 2006 | SpringerLink |
Información
Tipo de recurso:
libros
ISBN impreso
978-1-4020-3935-5
ISBN electrónico
978-1-4020-3959-1
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
2006
Información sobre derechos de publicación
© Springer Science+Business Media B.V. 2006
Cobertura temática
Tabla de contenidos
Mesenchymal Stem Cell Engineering and Transplantation
F. Aerts; G. Wagemaker
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 1-44
Establishment and Transduction of Primary Human Stromal/Mesenchymal Stem Cell Monolayers
T. Meyerrose; I. Rosova; M. Dao; P. Herrbrich; G. Bauer; J. Nolta
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 45-58
Gene Expression Profiles of Mesenchymal Stem Cells
D. G. Phinney
Past studies profiling gene expression in MSCs have typically revealed a preponderance of expressed transcripts encoding structural proteins common in skeletal tissue and secreted factors that regulate hematopoiesis. Our SAGE analysis of the MSC transcriptome corroborated many of these previous findings, but also revealed that the cells express a plethora of transcripts encoding proteins involved in cell communication, motility, neural activity, angiogenesis and other biological processes that characterize marrow stroma. Therefore, the heterogeneity of the MSC transcriptome appears to reflect the nature and function of the different cell types that comprise this organ, the complexity of which is under appreciated. Our studies also indicate that the transcriptome of a clonal MSC population is characterized by a high percentage of expressed transcripts encoding proteins of an indeterminate nature. These findings reflect a basic lack of knowledge regarding the biology of MSCs, which attributes to the difficulty in ascribing a molecular phenotype to these stem cells. Comparative genomics studies indicate that transcripts uniquely expressed in MSCs include transcription factors and signalling molecules involved in limb bud morphogenesis, thereby providing clues to the regulatory mechanisms governing self-renewal and lineage commitment of MSCs. Deciphering these molecular pathways will further our understanding of the nature and biology of this unique stem cell population.
Pp. 59-80
In Vivo Homing and Regeneration of Freshly Isolated and Cultured Murine Mesenchymal Stem Cells
R. E. Ploemacher
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 81-92
Non-Human Primate Models of Mesenchymal Stem Cell Transplantation
S. M. Devine; R. Hoffman
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 93-110
Engineering of Human Adipose-Derived Mesenchymal Stem-Like Cells
J. K. Fraser; M. Zhu; B. Strem; M. H. Hedrick
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 111-125
Uncommitted Progenitors in Cultures of Bone Marrow-Derived Mesenchymal Stem Cells
J. J. Minguell; A. Erices; W. D. Sierralta
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 127-133
Bone Marrow Mesenchymal Stem Cell Transplantation for Children with Severe Osteogenesis Imperfecta
E. M. Horwitz; P. L. Gordon
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 135-150
Clinical Trials of Human Mesenchymal Stem Cells to Support Hematopoietic Stem Cell Transplantation
O. N. Koç
In summary, adipose contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages. The cells possessing this activity can be obtained in large numbers at high frequency from a tissue source that can be extracted in large quantities with minimal morbidity. These cells can be infected by adenoviral, oncoretroviral, and lentiviral vectors with moderate to high efficiency. Thus, adipose tissue appears to represent a potential clinically useful source of cells for cellular therapy and gene transfer applications.
Pp. 151-162