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European Journal of Neuroscience

Resumen/Descripción – provisto por la editorial en inglés

EJN publishes original research articles and reviews in the broad fields of molecular, cellular, systems, behavioral, and cognitive neurosciences. EJN aims to advance our understanding of the nervous system in health and disease, thereby improving the diagnosis and treatment of neuropsychiatric and neurodegenerative disorders. Papers should present novel results that can be of interest to a broad spectrum of neuroscientists and that were generated by experiments guided by clearly defined aims or hypotheses. Highly specialized articles that provide only limited new insights into the organization and function of the nervous system, or describe results too specialized for a generalist neuroscience journal may be considered outside the scope of EJN.

Palabras clave – provistas por la editorial

European Journal of Neuroscience; neuroscience; neurology; neurosurgery; european; journal; pain; me

Disponibilidad

Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde ene. 1989 / hasta dic. 2023	Wiley Online Library

Información

Tipo de recurso:

revistas

ISSN impreso

0953-816X

ISSN electrónico

1460-9568

Editor responsable

John Wiley & Sons, Inc. (WILEY)

País de edición

Reino Unido

Fecha de publicación

1989-

Cobertura temática

Medicina básica

Medicina clínica

Tabla de contenidos

Verificá que desde tu institución tengas acceso para descargar o solicitar el libro completo o alguno de sus capítulos.

doi: 10.1046/j.0953-816x.2001.01806.x

The ubiquitin–proteasome cascade is required for mammalian long‐term memory formation

Mariella Lopez‐Salon; Mariana Alonso; Monica R. M. Vianna; Haydee Viola; Tadeu Mello E Souza; Ivan Izquierdo; Juana M. Pasquini; Jorge H. Medina

<jats:title>Abstract</jats:title><jats:p>It has been recently demonstrated that ubiquitin–proteasome‐mediated proteolysis is required for long‐term synaptic facilitation in <jats:italic>Aplysia.</jats:italic> Here we show that the hippocampal blockade of this proteolytic pathway is also required for the formation of long‐term memory in the rat. Bilateral infusion of lactacystin, a specific proteasome inhibitor, to the CA1 region caused full retrograde amnesia for a one‐trial inhibitory avoidance learning when given 1, 4 or 7h, but not 10 h, after training. Proteasome inhibitor I produced similar effects. In addition, inhibitory avoidance training resulted in an increased ubiquitination and 26S proteasome proteolytic activity and a decrease in the levels of IkappaB, a substrate of the ubiquitin–proteasome cascade, in hippocampus 4 h after training. Together, these findings indicate that the ubiquitin–proteasome cascade is crucial for the establishment of LTM in the behaving animal.</jats:p>