Catálogo de publicaciones - revistas
Clinical and Experimental Immunology
Resumen/Descripción – provisto por la editorial en inglés
Clinical & Experimental Immunology is a top ranking, international journal publishing biologically significant studies that have clinical relevance. The Journal is focused on Translational Immunology and is amongst the foremost journals in this field, attracting high-quality papers from all parts of the world. Translation is viewed as a process of applying ideas, insights and discoveries generated through basic scientific studies to the treatment, prevention or diagnosis of human disease. Journal articles cover clinical studies in patients receiving immune-based therapies, in relation to autoimmunity, primary and secondary immunodeficiencies, complement disorders and allergies. The Journal also reports investigations on the pathogenesis of rheumatic, renal and endocrine disorders, as well as infectious diseases, malignancy and transplantation. Basic immunology studies that inform clinical practice or understanding of disease mechanisms are also welcomed, as are studies in non-human model systems and reports on the physiological mechanisms of immunity.Palabras clave – provistas por la editorial
clinical and experimental immunology; allergy; autoimmunity; clinical immunology; gastrointestinal d
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde ene. 1990 / hasta dic. 2021 | Wiley Online Library |
Información
Tipo de recurso:
revistas
ISSN impreso
0009-9104
ISSN electrónico
1365-2249
Editor responsable
John Wiley & Sons, Inc. (WILEY)
País de edición
Reino Unido
Fecha de publicación
1966-2013
Cobertura temática
Tabla de contenidos
doi: 10.1111/cei.13622
Anti-JMH alloantibody in inherited JMH-negative patients leads to immunogenic destruction of JMH-positive RBCs
Zhaohu Yuan
; Yaming Wei; Xiaojie Chen; Shufei He; Kui Cai; Minglu Zhong; Huiying Huang; Xinxin Tong; Zhen Liu; Xuexin Yang
<jats:title>Summary</jats:title> <jats:p>The clinical significance of the specific anti-John Milton Hagen (JMH) alloantibody in inherited JMH-negative patients remains unclear. During clinical blood transfusion, it is often classified as an anti-JMH autoantibody in acquired JMH-negative patients, which might further lead to the occurrence of haemolysis events. In this study, we found that the proportion of inherited JMH-negative people in the Guangzhou population was 0.41%, based on the study of 243 blood samples by flow cytometry. Gene sequencing analysis revealed two novel variants located in exon 11 (c.1348G&gt;A, p.Ala449Thr) and exon 14 (c.1989G&gt;T, p.Leu663Phe). Specific antigen presentation showed that JMH-positive RBCs (red blood cells) could be internalized by SEMA7A−/− dendritic cells (DCs) and that SEMA7A−/− DCs activated by the semaphorin 7a (Sema7a) protein or JMH-positive erythrocytes further induced activation of CD4+ T cells to secrete interferon (IFN)-γ. Transfusion of JMH-positive RBCs could lead to the production of the specific anti-JMH alloantibody in Sema7a knock-out (KO) C57 mice. After erythrocyte sensitization, complement C3 was specifically fixed, causing the destruction of JMH-positive erythrocytes. The anti-JMH alloantibody caused immunological destruction of JMH-positive erythrocytes and promoted the clearance of JMH-positive RBCs. We should be cautious when making conclusions about the clinical significance of the anti-JMH alloantibody.</jats:p>
Palabras clave: Immunology; Immunology and Allergy.
Pp. 182-197