Catálogo de publicaciones - revistas

Compartir en
redes sociales


BJCP. British journal of clinical pharmacology

Resumen/Descripción – provisto por la editorial en inglés
Published on behalf of the British Pharmacological Society, the British Journal of Clinical Pharmacology contains papers and reports on all aspects of drug action in humans: invited review articles, original papers and correspondence. The Journal enjoys a wide readership, bridging the gap between the medical profession, clinical research and the pharmaceutical industry. Additionally supplements containing information on new methods, new drugs and new approaches to treatment are supplied free of charge.
All editorials now available to access free online.
Palabras clave – provistas por la editorial

british journal of clinical pharmacology; clinical trials; drugs; medicinal chemistry; pharmaceutica

Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde ene. 1974 / hasta dic. 2023 Wiley Online Library

Información

Tipo de recurso:

revistas

ISSN impreso

0306-5251

ISSN electrónico

1365-2125

Editor responsable

John Wiley & Sons, Inc. (WILEY)

País de edición

Reino Unido

Fecha de publicación

Tabla de contenidos

Performance of creatinine‐based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment

Pierre DelanayeORCID; Jonas Björk; Marie Courbebaisse; Lionel Couzi; Natalie Ebert; Björn O. Eriksen; R. Neil Dalton; Laurence Dubourg; Francois Gaillard; Cyril Garrouste; Anders Grubb; Lola Jacquemont; Magnus Hansson; Nassim Kamar; Edmund J. Lamb; Christophe Legendre; Karin Littmann; Christophe Mariat; Toralf Melsom; Lionel Rostaing; Andrew D. Rule; Elke Schaeffner; Per‐Ola Sundin; Ulla B. Berg; Kajsa Åsling‐Monemi; Luciano Selistre; Anna Åkesson; Anders Larsson; Arend Bökenkamp; Hans Pottel; Ulf Nyman

Palabras clave: Pharmacology (medical); Pharmacology.

Pp. 2118-2127

Comparative safety and efficacy of paracetamol versus non‐steroidal anti‐inflammatory agents in neonates with patent ductus arteriosus: A systematic review and meta‐analysis of randomized controlled trials

Dimitrios N. Katsaras; Georgios N. KatsarasORCID; Vasiliki I. ChatziravdeliORCID; Garyfalia N. Papavasileiou; Maria Touloupaki; Georgios Mitsiakos; Chrysoula Doxani; Ioannis Stefanidis; Efthimios Dardiotis

Palabras clave: Pharmacology (medical); Pharmacology.

Pp. 3078-3100

Risk factors for vancomycin‐associated acute kidney injury: A systematic review and meta‐analysis

Jee Yun Kim; Jeong Yee; Ha Young Yoon; Ji Min Han; Hye Sun GwakORCID

Palabras clave: Pharmacology (medical); Pharmacology.

Pp. 3977-3989

N‐of‐1 trials to facilitate evidence‐based deprescribing: Rationale and case study

Parag GoyalORCID; Monika M. Safford; Sarah N. HilmerORCID; Michael A. Steinman; Daniel D. Matlock; Mathew S. Maurer; Mark S. Lachs; Ian M. Kronish

Palabras clave: Pharmacology (medical); Pharmacology.

Pp. 4460-4473

Effects of intraoperative low‐dose esketamine on postoperative pain after vestibular schwannoma resection: A prospective randomized, double‐blind, placebo‐controlled study

Kaizheng Chen; Yaming Xie; Songyuan Chi; Dandan Chen; Guo Ran; Xia ShenORCID

<jats:sec><jats:title>Aims</jats:title><jats:p>Esketamine may reduce acute postoperative pain in several settings. However, the effects of low‐dose esketamine on postoperative pain after vestibular schwannoma (VS) resection with propofol/remifentanil total intravenous anaesthesia (TIVA) are unclear. The aim of this study is to observe the effects of intraoperative low‐dose esketamine on postoperative pain after vestibular schwannoma resection.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This single‐centre, randomized, placebo‐controlled, double‐blind trial included 90 adults undergoing VS resection via the retrosigmoid approach with TIVA. The patients were randomly allocated to two groups: esketamine or control (n = 45 in each group). Patients received low‐dose esketamine (0.2 mg/kg) or a similar volume of normal saline after dural closure. The primary outcome was the pain score during movement (gentle head movement) at 24 h postoperatively. Secondary outcomes included recovery time, bispectral index (BIS) values and haemodynamic profiles during the first 30 min after esketamine administration, and adverse effects.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Low‐dose esketamine did not reduce pain scores at rest (<jats:italic>P</jats:italic> &gt; .05) or with movement (<jats:italic>P</jats:italic> &gt; .05) within the first 24 h after surgery. Esketamine moderately increased BIS values for at least 30 min after administration (<jats:italic>P</jats:italic> &lt; .0001) but did not affect heart rate (P = .992) or mean arterial blood pressure (<jats:italic>P</jats:italic> = .994). Esketamine prolonged extubation time (<jats:italic>P</jats:italic> = .042, 95% confidence interval: 0.08 to 4.42) and decreased the effect‐site concentration of remifentanil at extubation (<jats:italic>P</jats:italic> = .001, 95% confidence interval: −0.53 to −0.15) but did not affect the time to resumption of spatial orientation. Postoperative nausea and vomiting rates did not differ between groups, and no hallucinations or excessive sedation was observed.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Intraoperative low‐dose esketamine did not significantly reduce acute pain after VS resection with propofol/remifentanil TIVA. However, BIS values increased for at least 30 min after esketamine administration.</jats:p></jats:sec>

Pp. No disponible