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Palabras clave – provistas por la editorial

nucleic acid structures; nucleic acid conformation; biological structure database; DNA; RNA; validation standards; G-quadruplex; replication; thermodynamics; ligand; topology; quadruplex-duplex hybrids; minor groove binding drugs; stability; optical spectroscopy; nucleic acids; charge; electrostatic potential; ab initio methods; NMR spectroscopy; molecular dynamics; forcefield; AMBER; B-DNA; DNA-hairpin; perchlorates; brines; pressure; Mars; habitability; DNA minor groove binder; mixed base-pair DNA sequences; sequence selectivity; ligand–DNA complex thermodynamic; molecular curvature; heterocyclic diamidine; biosensor; calorimetry; DNA conjugate; metal ion; triple helix; silver ion; lanthanide; ATP sensor; aptamer; terpyridine; sequence edition; DNAzyme; molecular dynamics simulation (MD); potential of mean force (PMF); dsDNA–dsDNA interactions; flexibility; origins of life; DNA-protein networks; protocells; DNA sequence-dependent structure; DNA deformability; DNA sequence context; DNA curvature; DNA minicircles; hydrostatic pressure; volume; CD spectroscopy; G-quadruplexes; potassium; polymorphism; kinetics; folding; kinetic models; fitting; aurintricarboxylic acid (ATA); salicylic acid polymers; methylene-salicylic acid; SARS-CoV-2; RNA-dependent RNA polymerase (RdRp); yeast ribosomes; human serum albumin (HSA); molecular recognition; biological function and viral disease; inhibitor binding; single-molecule biophysics; nucleic acid thermodynamics; statistical mechanics; fluctuation theorems; computational biophysics; n/a; drug discovery; drug-target interactions; thermodynamic binding signatures; isothermal titration calorimetry; lead optimization; fragment-based drug discovery; drug-like properties; enthalpic efficiency; group efficiency; lipophilic efficiency