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transforming growth factor beta-3; cardiac development; loeys dietz syndrome-5; arrhythmogenic right ventricular dysplasia; rienhoff syndrome; cleft palate; congenital heart disease; outflow tract septation; signaling networks; transcription factor AP-2α; cardiovascular development; outflow tract; pharyngeal arch artery; neural crest cell; pharyngeal ectoderm; Tetralogy of Fallot; monozygotic twins; discordant phenotype; genetics; variations; epigenetics; DNA methylation; candidate genes; acute aortic syndrome; cardiovascular disease; aorta; aortic valve replacement; surgical; aortic surgery; bicuspid aortic valve; Bentall; Kommerell’s diverticulum; right sided aortic arch; anomalous left subclavian artery; arteria lusoria; tracheal compression; esophageal compression; transposition great arteries coronary anatomy; Rac1; proliferation; cell polarity; congenital heart defects; compact myocardium; trabeculation; aortic stenosis; asymptomatic; early surgery; watchful waiting; cardiac progenitor cells; second heart field; neural crest; endocardium; cushion; valve; ductus arteriosus; neointima; tunica media; transcriptome; lineage tracing; developmental biology; cell identity; atrioventricular valve; epicardium; lateral cushion; major cushion; myxomatous degeneration; homograft; semilunar valves; aortic regurgitation; superimposed tissue; original leaflet; myofibroblasts; free edge folding; remodeling; dissection of ductus arteriosus; sudden unexpected intrauterine death; single coronary artery; Leiden Convention coronary coding system; Lipton classification; coronary artery anatomy; transposition of the great arteries; arterial switch operation; coronary artery; coronary complications; imaging; fetal aortic stenosis; prenatal ultrasound; postmortem histology; speckle tracking analysis; endocardial fibro-elastosis; endocardial cushions; cartilage; foramen of Panizza; left aorta; right aorta; pulmonary trunk; pharyngeal arch arteries; coronary arteries; cardiac fields; cardiomyocyte; progenitor specification; heart tube; aortic wall; cardiovascular pathogenesis; arterial duct