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Palabras clave – provistas por la editorial

dose-escalation; combination study; modelling assumption; interaction; adaptive designs; adaptive randomization; Bayesian designs; clinical trials; predictive power; target allocation; Bayesian inference; highest posterior density intervals; normal approximation; predictive analysis; sample size determination; bayesian meta-analysis; clustering; binary data; priors; frequentist validation; Bayesian; rare disease; prior distribution; meta-analysis; sample size; bridging studies; distribution distance; oncology; phase I; dose-finding; dose–response; bayesian inference; prior elicitation; latent dirichlet allocation; clinical trial; power-prior; poor accrual; Bayesian trial; cisplatin; doxorubicin; oxaliplatin; dose escalation; PIPAC; peritoneal carcinomatosis; randomized controlled trial; causal inference; doubly robust estimation; propensity score; Bayesian monitoring; futility rules; interim analysis; posterior and predictive probabilities; stopping boundaries; Bayesian trial design; early phase dose finding; treatment combinations; optimal dose combination