Catálogo de publicaciones - revistas

<jats:title>Targeting cyclin-dependent kinases</jats:title> <jats:p> Cyclin-dependent kinases (CDKs), in complex with their cyclin partners, modulate the transition through phases of the cell division cycle. Cyclin D–CDK complexes are important in cancer progression, especially for certain types of breast cancer. Fassl <jats:italic>et al</jats:italic> . discuss advances in understanding the biology of cyclin D–CDK complexes that have led to new concepts about how drugs that target these complexes induce cancer cell cytostasis and suggest possible combinations to widen the types of cancer that can be treated. They also discuss progress in overcoming resistance to cyclin D–CDK inhibitors and their possible application to diseases beyond cancer. —GKA </jats:p>

<jats:p> Madsen <jats:italic>et al</jats:italic> . question the reliability of calibrated radiocarbon ages associated with human footprints discovered recently in White Sands National Park, New Mexico, USA. On the basis of the geologic, hydrologic, stratigraphic, and chronologic evidence, we maintain that the ages are robust and conclude that the footprints date to between ~23,000 and 21,000 years ago. </jats:p> <jats:p> Madsen <jats:italic>et al</jats:italic> . ( <jats:xref ref-type="bibr"> <jats:italic>1</jats:italic> </jats:xref> ) question the veracity of calibrated radiocarbon ages used to constrain the antiquity of human trackways discovered recently at White Sands National Park (WHSA) Locality 2, New Mexico, USA ( <jats:xref ref-type="bibr"> <jats:italic>2</jats:italic> </jats:xref> ). The ages were derived from seeds of the aquatic plant <jats:italic>Ruppia cirrhosa</jats:italic> , which they suggest may suffer from hard-water (or reservoir) effects, making them too old, potentially by thousands of years. We were well aware of this possibility, investigated it, and presented several lines of evidence that argued against such a problem. Here we respond to each of their four primary points. </jats:p>

<jats:p> Bennett <jats:italic>et al</jats:italic> . (Reports, 24 September 2021, p. 1528) report human footprints from Lake Otero, New Mexico, USA ~22,000 years ago. Critical assessment suggests that their radiocarbon chronology may be inaccurate. Reservoir effects may have caused radiocarbon ages to appear thousands of years too old. Independent verification of the ages of the footprint horizons is imperative and is possible through other means. </jats:p>

<jats:title>Persuading people to mask</jats:title> <jats:p> Even in places where it is obligatory, people tend to optimistically overstate their compliance for mask wearing. How then can we persuade more of the population at large to act for the greater good? Abaluck <jats:italic>et al</jats:italic> . undertook a large, cluster-randomized trial in Bangladesh involving hundreds of thousands of people (although mostly men) over a 2-month period. Colored masks of various construction were handed out free of charge, accompanied by a range of mask-wearing promotional activities inspired by marketing research. Using a grassroots network of volunteers to help conduct the study and gather data, the authors discovered that mask wearing averaged 13.3% in villages where no interventions took place but increased to 42.3% in villages where in-person interventions were introduced. Villages where in-person reinforcement of mask wearing occurred also showed a reduction in reporting COVID-like illness, particularly in high-risk individuals. —CA </jats:p>

<jats:p>The rise and fall of Elizabeth Holmes, former chief executive officer (CEO) of the high-flying, privately held, American medical diagnostics company Theranos, has riveted the public for years. A bestseller, a documentary, and a seemingly endless stream of news stories have chronicled the drama, which came to a climax last week when a jury decided that Holmes committed fraud. Although a verdict has been rendered, it’s worth examining how the culture of science innovation contributed to the problem. For too long, fledging companies promoting technological and scientific advances have relied too much on style and not enough on substance.</jats:p>

<jats:p>Having just stepped down from serving three presidents over 12 years as director of the US National Institutes of Health (NIH), I am deeply grateful for the opportunity to have led this noble enterprise and to work with amazing people. Astounding progress has been made on many fronts, including advances that I never dreamed that I would see in my lifetime—let alone during my time as NIH director.</jats:p>

<jats:p>New analysis bolsters idea that country’s seemingly low death rate was misleading</jats:p>

<jats:p>Software that identifies unique styles poses privacy risks</jats:p>

<jats:p>Long-term antiretrovirals may corner viral genomes in inactive regions of DNA</jats:p>