Catálogo de publicaciones - revistas

<jats:p>Analysis of protein interaction networks can identify previously unknown oncogenic drivers</jats:p>

<jats:p>Advances in hemophilia gene therapy could enable progress in other inherited disorders</jats:p>

<jats:p>A history of tropical ecosystems emphasizes the importance of including human inhabitants in conservation conversations</jats:p>

<jats:p>Traveling trees, color-changing owls, and gale-proof reptiles showcase nature’s adaptability</jats:p>

<jats:p> Highlights from the <jats:italic>Science</jats:italic> family of journals </jats:p>

<jats:p>Editors’ selections from the current scientific literature</jats:p>

<jats:title>Keeping tabs on ER stress</jats:title> <jats:p> In the endoplasmic reticulum (ER), oligomerization is a central step in modulating signaling during the unfolded protein response. Tran <jats:italic>et al</jats:italic> . visualized the active, oligomeric form of the ER stress sensor IRE1α residing in an ER subdomain in stressed human cells. This ER region was composed of narrow (diameter about 28 nanometers) anastomosing ER tubes with a high degree of branching and was continuous with surrounding ER structures. Within the lumen of these narrow IRE1α subdomain tubes, regular protein densities were observed, consistent with ordered oligomers of the lumenal stress–sensing domain of IRE1α. This arrangement may suggest a positive feedback mechanism involved in signaling by IRE1α. —SMH </jats:p>

<jats:title>Tracing the origin of CRISPR-Cas</jats:title> <jats:p> CRISPR-Cas systems have transformed genome editing and other biotechnologies; however, the broader origins and diversity of RNA-guided nucleases have largely remained unexplored. Altae-Tran <jats:italic>et al</jats:italic> . show that three distinct transposon-encoded proteins, IscB, IsrB, and TnpB, are naturally occurring, reprogrammable RNA-guided DNA nucleases (see the Perspective by Rousset and Sorek). In addition to identifying diverse guide-encoding mechanisms, the authors elucidate the evolutionary relationship between IsrB, IscB, and CRISPR-Cas9. Overall, these newly characterized systems, called OMEGA (for obligate mobile element–guided activity) systems, are found in all domains of life and may be harnessed for biotechnology development. —DJ </jats:p>

<jats:title>Nitrogen fixation in legume roots</jats:title> <jats:p> Soybeans and other legumes form symbiotic relationships with nitrogen-fixing bacteria in root nodules, thus ensuring the plant a ready supply of the necessary nutrient. Wang <jats:italic>et al</jats:italic> . worked out the signaling pathways that integrate above-ground light with below-ground root nodulation. Two mobile regulators move from shoot to root in response to light and, together, they form a signaling module in the root that induces the expression of nodulation factors. Thus, when the shoot sees enough light to support photosynthetic productivity, the root gets the signal to ramp up nitrogen fixation. —PJH </jats:p>

<jats:title>Reducing net emission</jats:title> <jats:p> The great majority of plastics in current use are sourced from fossil fuels, with additional fossil fuels combusted to power their manufacture. Substantial research is focused on finding more sustainable building blocks for next-generation polymers. Meys <jats:italic>et al</jats:italic> . report a series of life cycle analyses suggesting that even the current varieties of commercial monomers could potentially be manufactured and polymerized with no net greenhouse gas emissions. The cycle relies on combining recycling of plastic waste with chemical reduction of carbon dioxide captured from incineration or derived from biomass. —JSY </jats:p>