Catálogo de publicaciones - revistas

<jats:title>Mom’s IL-6 rewires baby’s gut immunity</jats:title> <jats:p> Most infections that occur during pregnancy are mild and transient. However, whether such pathogen encounters can shape the long-term trajectory of the offspring’s immune system remains unclear. Lim <jats:italic>et al</jats:italic> . infected pregnant mice with the common food-borne pathogen <jats:italic>Yersinia pseudotuberculosis</jats:italic> (YopM) (see the Perspective by Amir and Zeng). Although the infection was maternally restricted and short-lived, the offspring harbored greater numbers of intestinal T helper 17 cells into adulthood. Interleukin-6 (IL-6) mediated this tissue-restricted effect by acting on fetal intestinal epithelium during development. Although offspring from mothers infected with YopM or injected with IL-6 showed enhanced resistance to oral infection with <jats:italic>Salmonella</jats:italic> Typhimurium, they also exhibited higher susceptibility toward enteric inflammatory disease. —STS </jats:p>

<jats:title>The cerebellum reveals its genetic programs</jats:title> <jats:p> Gene-regulatory networks govern the development of organs. Sarropoulos <jats:italic>et al</jats:italic> . analyzed mouse cerebellar development in the context of gene-regulatory networks. Single nuclear profiles analyzing chromatin accessibility in about 90,000 cells revealed diversity in progenitor cells and genetic programs guiding cellular differentiation. The footsteps of evolution were apparent in varying constraints on different cell types. —PJH </jats:p>

<jats:title>Bright future ahead for crystallography</jats:title> <jats:p>Macromolecular x-ray crystallography typically provides static snapshots of systems at equilibrium. Advances in time-resolved crystallography have made it possible to capture dynamics in biomolecules: large and small, fast and slow. Brändén and Neutze review techniques and concepts that have emerged from recent work at x-ray free electron laser sources and are now being applied in other settings and to a growing number of biological systems. Despite challenges in analyzing and relating these data to a biological context, experiments in this field have opened new frontiers in temporal and spatial resolution and yielded many new insights into nonequilibrium chemistry and conformational changes in biology. —MAF</jats:p>

<jats:title>Mechanisms of airborne transmission</jats:title> <jats:p> The COVID-19 pandemic has highlighted controversies and unknowns about how respiratory pathogens spread between hosts. Traditionally, it was thought that respiratory pathogens spread between people through large droplets produced in coughs and through contact with contaminated surfaces (fomites). However, several respiratory pathogens are known to spread through small respiratory aerosols, which can float and travel in air flows, infecting people who inhale them at short and long distances from the infected person. Wang <jats:italic>et al</jats:italic> . review recent advances in understanding airborne transmission gained from studying the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and other respiratory pathogens. The authors suggest that airborne transmission may be the dominant form of transmission for several respiratory pathogens, including SARS-CoV-2, and that further understanding of the mechanisms underlying infection from the airborne route will better inform mitigation measures. —GKA </jats:p>

<jats:p>This week, the US Food and Drug Administration (FDA) granted full approval to the Pfizer-BioNTech coronavirus vaccine for individuals 16 years and older. This milestone decision, the first full approval of a vaccine for COVID-19, will almost certainly clear a path for businesses, hospitals, and government agencies that have not already done so to adopt vaccine mandates for their employees. For colleges and universities that have been on the fence about requiring the vaccine, the FDA’s decision may be especially welcome news.</jats:p>

<jats:p>Many scramble to leave the country in fear of return to harsh “antiscience” rule</jats:p>