Catálogo de publicaciones - revistas

<jats:title>Estimating resilience in complex systems</jats:title> <jats:p> Resilience is an important concept in the study of critical transitions and tipping points in complex systems and is defined by the size of the disturbance that a system can endure before tipping into an alternative stable state. Nevertheless, resilience has proved resistant to measurement. Arani <jats:italic>et al.</jats:italic> show how the mathematical concept of mean exit time, the time it takes for a system to cross a threshold, can help to solve this problem and characterize the resilience of complex systems. They derived a model approach to estimate exit time from time series data and applied it to examples from a grazed plant population model, lake cyanobacterial data, and Pleistocene-Holocene climate data. This approach may improve our understanding of the dynamical properties of complex systems under threat. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , aay4895, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay4895">eaay4895</jats:related-article> </jats:p>

<jats:title>Astronomy accelerates tumor imaging</jats:title> <jats:p> Immunohistochemical stains for individual markers revolutionized diagnostic pathology decades ago but cannot capture enough information to accurately predict response to immunotherapy. Newer multiplex immunofluorescent technologies provide the potential to visualize the expression patterns of many functionally relevant molecules but present numerous challenges in accurate image analysis and data handling, particularly over large tumor areas. Drawing from the field of astronomy, in which petabytes of imaging data are routinely analyzed across a wide spectral range, Berry <jats:italic>et al.</jats:italic> developed a platform for multispectral imaging of whole-tumor sections with high-fidelity single-cell resolution. The resultant AstroPath platform was used to develop a multiplex immunofluorescent assay highly predictive of responses and outcomes for melanoma patients receiving immunotherapy. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , aba2609, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba2609">eaba2609</jats:related-article> </jats:p>