Catálogo de publicaciones - revistas

<jats:title>Bacterial effectors manipulate membranes</jats:title> <jats:p> Many pathogenic bacteria use molecular syringes to translocate proteins called effectors into the host cell to hijack the cellular machinery for their proliferation. <jats:italic>Legionella pneumophila</jats:italic> , the causative bacteria of Legionnaires' disease, uses a large effector arsenal and harnesses the host membrane system to establish a specialized vacuole where it replicates. Hsieh <jats:italic>et al.</jats:italic> show that, within this effector arsenal, the phospholipid kinase MavQ and the phosphatase SidP work together and self-organize on the intracellular membrane network of its eukaryotic host to promote membrane remodeling. The interactions between MavQ and SidP constitute positive and negative feedback loops, respectively, that orchestrate their spatiotemporal oscillation during infection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , aay8118, this issue p. <jats:related-article issue="6545" page="935" related-article-type="in-this-issue" vol="372">935</jats:related-article> </jats:p>

<jats:title>Cellular RNAs guide CRISPR-Cas9</jats:title> <jats:p> The Cas9 nuclease widely used for genome editing is derived from natural bacterial defense systems that protect against invading viruses. Cas9 is directed by RNA guides to cut matching viral DNA. Jiao <jats:italic>et al.</jats:italic> discovered that RNA guides can also originate from cellular RNAs unassociated with viral defense (see the Perspective by Abudayyeh and Gootenberg). They rendered this process programmable, linking the presence of virtually any RNA to cutting of matching DNA by Cas9. This capability is the basis of a new CRISPR diagnostic method developed by the authors that can detect many biomarkers at once. Named LEOPARD, this method can detect, for example, RNAs from severe acute respiratory syndrome coronavirus 2 and other viruses, thereby translating a new CRISPR discovery into a powerful diagnostic tool. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abe7106, this issue p. <jats:related-article issue="6545" page="941" related-article-type="in-this-issue" vol="372">941</jats:related-article> ; see also abi9335, p. <jats:related-article issue="6545" page="914" related-article-type="in-this-issue" vol="372">914</jats:related-article> </jats:p>

<jats:title>Simulating quantum walkers</jats:title> <jats:p> Quantum walks are the quantum mechanical analogs of classical random walks, describing the propagation of a quantum walker across a lattice, and find application in developing algorithms for simulating quantum many-body systems. Gong <jats:italic>et al.</jats:italic> used an 8-by-8 two-dimensional (2D) superconducting qubit square lattice containing 62 functional qubits to show how multiple (two) walkers traverse a 2D qubit array, interfering as they go. The authors were also able to program the paths that the walkers follow, demonstrating a Mach-Zehnder interferometer in which a single or multiple quantum walkers coherently traverse two paths before interfering and exiting at a single port. The results illustrate the potential for superconducting-based quantum processors in simulating large-scale quantum systems. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abg7812, this issue p. <jats:related-article issue="6545" page="948" related-article-type="in-this-issue" vol="372">948</jats:related-article> </jats:p>

<jats:title>Speeding reactions through ionic strength</jats:title> <jats:p> Brønsted acidity is introduced into microporous zeolites through the addition of framework aluminum. Pfriem <jats:italic>et al.</jats:italic> show that in the presence of water, the limited volume in the microchannels of zeolite H-MFI leads to a high concentration of hydrated hydronium ions at aluminum sites. The resulting high charge density creates a highly non-ideal solvation environment and, for cyclohexanol dehydrogenation, the charged carbenium-ion transition state was stabilized. A higher rate was maintained with lower-acidity sodium ion–exchanged zeolites that had the same high ionic strength. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abh3418, this issue p. <jats:related-article issue="6545" page="952" related-article-type="in-this-issue" vol="372">952</jats:related-article> </jats:p>