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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Lei Han
; Xiaoyu Wei; Chuanyu Liu; Giacomo Volpe; Zhenkun Zhuang; Xuanxuan Zou; Zhifeng Wang; Taotao Pan; Yue Yuan; Xiao Zhang; Peng Fan; Pengcheng Guo; Yiwei Lai; Ying Lei; Xingyuan Liu; Feng Yu; Shuncheng Shangguan; Guangyao Lai; Qiuting Deng; Ya Liu; Liang Wu; Quan Shi; Hao Yu; Yunting Huang; Mengnan Cheng; Jiangshan Xu; Yang Liu; Mingyue Wang; Chunqing Wang; Yuanhang Zhang; Duo Xie; Yunzhi Yang; Yeya Yu; Huiwen Zheng; Yanrong Wei; Fubaoqian Huang; Junjie Lei; Waidong Huang; Zhiyong Zhu; Haorong Lu; Bo Wang; Xiaofeng Wei; Fengzhen Chen; Tao Yang; Wensi Du; Jing Chen; Shibo Xu; Juan An; Carl Ward; Zongren Wang; Zhong Pei; Chi-Wai Wong; Xiaolei Liu; Huafeng Zhang; Mingyuan Liu; Baoming Qin; Axel Schambach; Joan Isern; Liqiang Feng; Yan Liu; Xiangyu Guo; Zhen Liu; Qiang Sun; Patrick H. Maxwell; Nick Barker; Pura Muñoz-Cánoves; Ying Gu; Jan Mulder; Mathias Uhlen; Tao Tan; Shiping Liu; Huanming Yang; Jian Wang; Yong Hou; Xun Xu; Miguel A. Esteban; Longqi Liu
Palabras clave: Multidisciplinary.
Pp. 723-731
Environmental factors shaping the gut microbiome in a Dutch population
R. Gacesa; A. Kurilshikov; A. Vich Vila; T. Sinha; M. A. Y. Klaassen; L. A. Bolte; S. Andreu-Sánchez; L. Chen; V. Collij; S. Hu; J. A. M. Dekens; V. C. Lenters; J. R. Björk; J. C. Swarte; M. A. Swertz; B. H. Jansen; J. Gelderloos-Arends; S. Jankipersadsing; M. Hofker; R. C. H. Vermeulen; S. Sanna; H. J. M. Harmsen; C. Wijmenga; J. Fu; A. Zhernakova; R. K. Weersma
Palabras clave: Multidisciplinary.
Pp. 732-739
Specification of CNS macrophage subsets occurs postnatally in defined niches
Takahiro Masuda; Lukas Amann; Gianni Monaco; Roman Sankowski; Ori Staszewski; Martin Krueger; Francesca Del Gaudio; Liqun He; Neil Paterson; Elisa Nent; Francisco Fernández-Klett; Ayato Yamasaki; Maximilian Frosch; Maximilian Fliegauf; Lance Fredrick Pahutan Bosch; Hatice Ulupinar; Nora Hagemeyer; Dietmar Schreiner; Cayce Dorrier; Makoto Tsuda; Claudia Grothe; Anne Joutel; Richard Daneman; Christer Betsholtz; Urban Lendahl; Klaus-Peter Knobeloch; Tim Lämmermann; Josef Priller; Katrin Kierdorf; Marco Prinz
Palabras clave: Multidisciplinary.
Pp. 740-748
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition
David Gallo; Jordan T. F. Young; Jimmy Fourtounis; Giovanni Martino; Alejandro Álvarez-Quilón; Cynthia Bernier; Nicole M. Duffy; Robert Papp; Anne Roulston; Rino Stocco; Janek Szychowski; Artur Veloso; Hunain Alam; Prasamit S. Baruah; Alexanne Bonneau Fortin; Julian Bowlan; Natasha Chaudhary; Jessica Desjardins; Evelyne Dietrich; Sara Fournier; Chloe Fugère-Desjardins; Theo Goullet de Rugy; Marie-Eve Leclaire; Bingcan Liu; Vivek Bhaskaran; Yael Mamane; Henrique Melo; Olivier Nicolas; Akul Singhania; Rachel K. Szilard; Ján Tkáč; Shou Yun Yin; Stephen J. Morris; Michael Zinda; C. Gary Marshall; Daniel Durocher
<jats:title>Abstract</jats:title><jats:p>Amplification of the <jats:italic>CCNE1</jats:italic> locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instability, whole-genome doubling and resistance to cytotoxic and targeted therapies<jats:sup>1–4</jats:sup>. To uncover therapeutic targets for tumours with <jats:italic>CCNE1</jats:italic> amplification, we undertook genome-scale CRISPR–Cas9-based synthetic lethality screens in cellular models of <jats:italic>CCNE1</jats:italic> amplification. Here we report that increasing <jats:italic>CCNE1</jats:italic> dosage engenders a vulnerability to the inhibition of the PKMYT1 kinase, a negative regulator of CDK1. To inhibit PKMYT1, we developed RP-6306, an orally bioavailable and selective inhibitor that shows single-agent activity and durable tumour regressions when combined with gemcitabine in models of <jats:italic>CCNE1</jats:italic> amplification. RP-6306 treatment causes unscheduled activation of CDK1 selectively in <jats:italic>CCNE1-</jats:italic>overexpressing cells, promoting early mitosis in cells undergoing DNA synthesis. <jats:italic>CCNE1</jats:italic> overexpression disrupts CDK1 homeostasis at least in part through an early activation of the MMB–FOXM1 mitotic transcriptional program. We conclude that PKMYT1 inhibition is a promising therapeutic strategy for <jats:italic>CCNE1</jats:italic>-amplified cancers.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 749-756
The tethered peptide activation mechanism of adhesion GPCRs
Ximena Barros-Álvarez; Robert M. Nwokonko; Alexander Vizurraga; Donna Matzov; Feng He; Makaía M. Papasergi-Scott; Michael J. Robertson; Ouliana Panova; Eliane Hadas Yardeni; Alpay B. Seven; Frank E. Kwarcinski; Hongyu Su; Maria Claudia Peroto; Justin G. Meyerowitz; Moran Shalev-Benami; Gregory G. Tall; Georgios Skiniotis
Palabras clave: Multidisciplinary.
Pp. 757-762
Structural basis for the tethered peptide activation of adhesion GPCRs
Yu-Qi Ping; Peng Xiao; Fan Yang; Ru-Jia Zhao; Sheng-Chao Guo; Xu Yan; Xiang Wu; Chao Zhang; Yan Lu; Fenghui Zhao; Fulai Zhou; Yue-Tong Xi; Wanchao Yin; Feng-Zhen Liu; Dong-Fang He; Dao-Lai Zhang; Zhong-Liang Zhu; Yi Jiang; Lutao Du; Shi-Qing Feng; Torsten Schöneberg; Ines Liebscher; H. Eric Xu; Jin-Peng Sun
Palabras clave: Multidisciplinary.
Pp. 763-770
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4
Peng Xiao; Shengchao Guo; Xin Wen; Qing-Tao He; Hui Lin; Shen-Ming Huang; Lu Gou; Chao Zhang; Zhao Yang; Ya-Ni Zhong; Chuan-Cheng Yang; Yu Li; Zheng Gong; Xiao-Na Tao; Zhi-Shuai Yang; Yan Lu; Shao-Long Li; Jun-Yan He; Chuanxin Wang; Lei Zhang; Liangliang Kong; Jin-Peng Sun; Xiao Yu
Palabras clave: Multidisciplinary.
Pp. 771-778
Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
Xiangli Qu; Na Qiu; Mu Wang; Bingjie Zhang; Juan Du; Zhiwei Zhong; Wei Xu; Xiaojing Chu; Limin Ma; Cuiying Yi; Shuo Han; Wenqing Shui; Qiang Zhao; Beili Wu
<jats:title>Abstract</jats:title><jats:p>Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological processes such as immune responses, organ development, cellular communication, proliferation and homeostasis<jats:sup>1–7</jats:sup>. An intrinsic manner of activation that involves a tethered agonist in the N-terminal region of the receptor has been proposed for the aGPCRs<jats:sup>8,9</jats:sup>, but its molecular mechanism remains elusive. Here we report the G protein-bound structures of ADGRD1 and ADGRF1, which exhibit many unique features with regard to the tethered agonism. The stalk region that proceeds the first transmembrane helix acts as the tethered agonist by forming extensive interactions with the transmembrane domain; these interactions are mostly conserved in ADGRD1 and ADGRF1, suggesting that a common stalk–transmembrane domain interaction pattern is shared by members of the aGPCR family. A similar stalk binding mode is observed in the structure of autoproteolysis-deficient ADGRF1, supporting a cleavage-independent manner of receptor activation. The stalk-induced activation is facilitated by a cascade of inter-helix interaction cores that are conserved in positions but show sequence variability in these two aGPCRs. Furthermore, the intracellular region of ADGRF1 contains a specific lipid-binding site, which proves to be functionally important and may serve as the recognition site for the previously discovered endogenous ADGRF1 ligand synaptamide. These findings highlight the diversity and complexity of the signal transduction mechanisms of the aGPCRs.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 779-785
Retraction Note: Epitaxy of advanced nanowire quantum devices
Sasa Gazibegovic; Diana Car; Hao Zhang; Stijn C. Balk; John A. Logan; Michiel W. A. de Moor; Maja C. Cassidy; Rudi Schmits; Di Xu; Guanzhong Wang; Peter Krogstrup; Roy L. M. Op het Veld; Kun Zuo; Yoram Vos; Jie Shen; Daniël Bouman; Borzoyeh Shojaei; Daniel Pennachio; Joon Sue Lee; Petrus J. van Veldhoven; Sebastian Koelling; Marcel A. Verheijen; Leo P. Kouwenhoven; Chris J. Palmstrøm; Erik P. A. M. Bakkers
Palabras clave: Multidisciplinary.
Pp. 786-786
How to handle a supervisor’s sudden departure
Nikki Forrester
Palabras clave: Multidisciplinary.
Pp. 787-789