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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
The field-free Josephson diode in a van der Waals heterostructure
Heng Wu
; Yaojia Wang; Yuanfeng Xu; Pranava K. Sivakumar; Chris Pasco; Ulderico Filippozzi; Stuart S. P. Parkin; Yu-Jia Zeng; Tyrel McQueen; Mazhar N. Ali
Palabras clave: Multidisciplinary.
Pp. 653-656
Engineered jumpers overcome biological limits via work multiplication
Elliot W. Hawkes; Charles Xiao; Richard-Alexandre Peloquin; Christopher Keeley; Matthew R. Begley; Morgan T. Pope; Günter Niemeyer
Palabras clave: Multidisciplinary.
Pp. 657-661
Machine learning-aided engineering of hydrolases for PET depolymerization
Hongyuan Lu; Daniel J. Diaz; Natalie J. Czarnecki; Congzhi Zhu; Wantae Kim; Raghav Shroff; Daniel J. Acosta; Bradley R. Alexander; Hannah O. Cole; Yan Zhang; Nathaniel A. Lynd; Andrew D. Ellington; Hal S. Alper
Palabras clave: Multidisciplinary.
Pp. 662-667
Computer-designed repurposing of chemical wastes into drugs
Agnieszka Wołos; Dominik Koszelewski; Rafał Roszak; Sara Szymkuć; Martyna Moskal; Ryszard Ostaszewski; Brenden T. Herrera; Josef M. Maier; Gordon Brezicki; Jonathon Samuel; Justin A. M. Lummiss; D. Tyler McQuade; Luke Rogers; Bartosz A. Grzybowski
Palabras clave: Multidisciplinary.
Pp. 668-676
Catalytic synthesis of phenols with nitrous oxide
Franck Le Vaillant; Ana Mateos Calbet; Silvia González-Pelayo; Edward J. Reijerse; Shengyang Ni; Julia Busch; Josep Cornella
<jats:title>Abstract</jats:title><jats:p>The development of catalytic chemical processes that enable the revalorization of nitrous oxide (N<jats:sub>2</jats:sub>O) is an attractive strategy to alleviate the environmental threat posed by its emissions<jats:sup>1–6</jats:sup>. Traditionally, N<jats:sub>2</jats:sub>O has been considered an inert molecule, intractable for organic chemists as an oxidant or O-atom transfer reagent, owing to the harsh conditions required for its activation (>150 °C, 50‒200 bar)<jats:sup>7–11</jats:sup>. Here we report an insertion of N<jats:sub>2</jats:sub>O into a Ni‒C bond under mild conditions (room temperature, 1.5–2 bar N<jats:sub>2</jats:sub>O), thus delivering valuable phenols and releasing benign N<jats:sub>2</jats:sub>. This fundamentally distinct organometallic C‒O bond-forming step differs from the current strategies based on reductive elimination and enables an alternative catalytic approach for the conversion of aryl halides to phenols. The process was rendered catalytic by means of a bipyridine-based ligands for the Ni centre. The method is robust, mild and highly selective, able to accommodate base-sensitive functionalities as well as permitting phenol synthesis from densely functionalized aryl halides. Although this protocol does not provide a solution to the mitigation of N<jats:sub>2</jats:sub>O emissions, it represents a reactivity blueprint for the mild revalorization of abundant N<jats:sub>2</jats:sub>O as an O source.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 677-683
Pterosaur melanosomes support signalling functions for early feathers
Aude Cincotta; Michaël Nicolaï; Hebert Bruno Nascimento Campos; Maria McNamara; Liliana D’Alba; Matthew D. Shawkey; Edio-Ernst Kischlat; Johan Yans; Robert Carleer; François Escuillié; Pascal Godefroit
<jats:title>Abstract</jats:title><jats:p>Remarkably well-preserved soft tissues in Mesozoic fossils have yielded substantial insights into the evolution of feathers<jats:sup>1</jats:sup>. New evidence of branched feathers in pterosaurs suggests that feathers originated in the avemetatarsalian ancestor of pterosaurs and dinosaurs in the Early Triassic<jats:sup>2</jats:sup>, but the homology of these pterosaur structures with feathers is controversial<jats:sup>3,4</jats:sup>. Reports of pterosaur feathers with homogeneous ovoid melanosome geometries<jats:sup>2,5</jats:sup> suggest that they exhibited limited variation in colour, supporting hypotheses that early feathers functioned primarily in thermoregulation<jats:sup>6</jats:sup>. Here we report the presence of diverse melanosome geometries in the skin and simple and branched feathers of a tapejarid pterosaur from the Early Cretaceous found in Brazil. The melanosomes form distinct populations in different feather types and the skin, a feature previously known only in theropod dinosaurs, including birds. These tissue-specific melanosome geometries in pterosaurs indicate that manipulation of feather colour—and thus functions of feathers in visual communication—has deep evolutionary origins. These features show that genetic regulation of melanosome chemistry and shape<jats:sup>7–9</jats:sup> was active early in feather evolution.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 684-688
Somatic mosaicism reveals clonal distributions of neocortical development
Martin W. Breuss; Xiaoxu Yang; Johannes C. M. Schlachetzki; Danny Antaki; Addison J. Lana; Xin Xu; Changuk Chung; Guoliang Chai; Valentina Stanley; Qiong Song; Traci F. Newmeyer; An Nguyen; Sydney O’Brien; Marten A. Hoeksema; Beibei Cao; Alexi Nott; Jennifer McEvoy-Venneri; Martina P. Pasillas; Scott T. Barton; Brett R. Copeland; Shareef Nahas; Lucitia Van Der Kraan; Yan Ding; Joseph G. Gleeson; Martin W. Breuss; Xiaoxu Yang; Danny Antaki; Changuk Chung; Dan Averbuj; Eric Courchesne; Laurel L. Ball; Subhojit Roy; Daniel Weinberger; Andrew Jaffe; Apua Paquola; Jennifer Erwin; Jooheon Shin; Michael McConnell; Richard Straub; Rujuta Narurkar; Gary Mathern; Christopher A. Walsh; Alice Lee; August Yue Huang; Alissa D’Gama; Caroline Dias; Eduardo Maury; Javier Ganz; Michael Lodato; Michael Miller; Pengpeng Li; Rachel Rodin; Rebeca Borges-Monroy; Robert Hill; Sara Bizzotto; Sattar Khoshkhoo; Sonia Kim; Zinan Zhou; Peter J. Park; Alison Barton; Alon Galor; Chong Chu; Craig Bohrson; Doga Gulhan; Elaine Lim; Euncheon Lim; Giorgio Melloni; Isidro Cortes; Jake Lee; Joe Luquette; Lixing Yang; Maxwell Sherman; Michael Coulter; Minseok Kwon; Semin Lee; Soo Lee; Vinary Viswanadham; Yanmei Dou; Andrew J. Chess; Attila Jones; Chaggai Rosenbluh; Schahram Akbarian; Ben Langmead; Jeremy Thorpe; Sean Cho; Alexej Abyzov; Taejeong Bae; Yeongjun Jang; Yifan Wang; Cindy Molitor; Mette Peters; Fred H. Gage; Meiyan Wang; Patrick Reed; Sara Linker; Alexander Urban; Bo Zhou; Reenal Pattni; Xiaowei Zhu; Aitor Serres Amero; David Juan; Inna Povolotskaya; Irene Lobon; Manuel Solis Moruno; Raquel Garcia Perez; Tomas Marques-Bonet; Eduardo Soriano; John V. Moran; Chen Sun; Diane A. Flasch; Trenton J. Frisbie; Huira C. Kopera; Jeffrey M. Kidd; John B. Moldovan; Kenneth Y. Kwan; Ryan E. Mills; Sarah B. Emery; Weichen Zhou; Xuefang Zhao; Aakrosh Ratan; Flora M. Vaccarino; Adriana Cherskov; Alexandre Jourdon; Liana Fasching; Nenad Sestan; Sirisha Pochareddy; Soraya Scuder; Christopher K. Glass; Joseph G. Gleeson;
Palabras clave: Multidisciplinary.
Pp. 689-696
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Gwenaëlle Douaud; Soojin Lee; Fidel Alfaro-Almagro; Christoph Arthofer; Chaoyue Wang; Paul McCarthy; Frederik Lange; Jesper L. R. Andersson; Ludovica Griffanti; Eugene Duff; Saad Jbabdi; Bernd Taschler; Peter Keating; Anderson M. Winkler; Rory Collins; Paul M. Matthews; Naomi Allen; Karla L. Miller; Thomas E. Nichols; Stephen M. Smith
<jats:title>Abstract</jats:title><jats:p>There is strong evidence of brain-related abnormalities in COVID-19<jats:sup>1–13</jats:sup>. However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here we investigated brain changes in 785 participants of UK Biobank (aged 51–81 years) who were imaged twice using magnetic resonance imaging, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans—with 141 days on average separating their diagnosis and the second scan—as well as 384 controls. The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects. We identified significant longitudinal effects when comparing the two groups, including (1) a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; (2) greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and (3) a greater reduction in global brain size in the SARS-CoV-2 cases. The participants who were infected with SARS-CoV-2 also showed on average a greater cognitive decline between the two time points. Importantly, these imaging and cognitive longitudinal effects were still observed after excluding the 15 patients who had been hospitalised. These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease through olfactory pathways, of neuroinflammatory events, or of the loss of sensory input due to anosmia. Whether this deleterious effect can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow-up.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 697-707
Modulation of inhibitory communication coordinates looking and reaching
Maureen A. Hagan; Bijan Pesaran
Palabras clave: Multidisciplinary.
Pp. 708-713
Somatic genomic changes in single Alzheimer’s disease neurons
Michael B. Miller; August Yue Huang; Junho Kim; Zinan Zhou; Samantha L. Kirkham; Eduardo A. Maury; Jennifer S. Ziegenfuss; Hannah C. Reed; Jennifer E. Neil; Lariza Rento; Steven C. Ryu; Chanthia C. Ma; Lovelace J. Luquette; Heather M. Ames; Derek H. Oakley; Matthew P. Frosch; Bradley T. Hyman; Michael A. Lodato; Eunjung Alice Lee; Christopher A. Walsh
Palabras clave: Multidisciplinary.
Pp. 714-722