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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Entropy of city street networks linked to future spatial navigation ability
A. Coutrot
; E. Manley; S. Goodroe; C. Gahnstrom; G. Filomena; D. Yesiltepe; R. C. Dalton; J. M. Wiener; C. Hölscher; M. Hornberger; H. J. Spiers
Palabras clave: Multidisciplinary.
Pp. 104-110
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
Preetish Kadur Lakshminarasimha Murthy; Vishwaraj Sontake; Aleksandra Tata; Yoshihiko Kobayashi; Lauren Macadlo; Kenichi Okuda; Ansley S. Conchola; Satoko Nakano; Simon Gregory; Lisa A. Miller; Jason R. Spence; John F. Engelhardt; Richard C. Boucher; Jason R. Rock; Scott H. Randell; Purushothama Rao Tata
Palabras clave: Multidisciplinary.
Pp. 111-119
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
Maria C. Basil; Fabian L. Cardenas-Diaz; Jaymin J. Kathiriya; Michael P. Morley; Justine Carl; Alexis N. Brumwell; Jeremy Katzen; Katherine J. Slovik; Apoorva Babu; Su Zhou; Madison M. Kremp; Katherine B. McCauley; Shanru Li; Joseph D. Planer; Shah S. Hussain; Xiaoming Liu; Rebecca Windmueller; Yun Ying; Kathleen M. Stewart; Michelle Oyster; Jason D. Christie; Joshua M. Diamond; John F. Engelhardt; Edward Cantu; Steven M. Rowe; Darrell N. Kotton; Harold A. Chapman; Edward E. Morrisey
Palabras clave: Multidisciplinary.
Pp. 120-126
Plant phytochrome B is an asymmetric dimer with unique signalling potential
Hua Li; E. Sethe Burgie; Zachary T. K. Gannam; Huilin Li; Richard D. Vierstra
Palabras clave: Multidisciplinary.
Pp. 127-133
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2
David C. Schultz; Robert M. Johnson; Kasirajan Ayyanathan; Jesse Miller; Kanupriya Whig; Brinda Kamalia; Mark Dittmar; Stuart Weston; Holly L. Hammond; Carly Dillen; Jeremy Ardanuy; Louis Taylor; Jae Seung Lee; Minghua Li; Emily Lee; Clarissa Shoffler; Christopher Petucci; Samuel Constant; Marc Ferrer; Christoph A. Thaiss; Matthew B. Frieman; Sara Cherry
Palabras clave: Multidisciplinary.
Pp. 134-140
Germinal centre-driven maturation of B cell response to mRNA vaccination
Wooseob Kim; Julian Q. Zhou; Stephen C. Horvath; Aaron J. Schmitz; Alexandria J. Sturtz; Tingting Lei; Zhuoming Liu; Elizaveta Kalaidina; Mahima Thapa; Wafaa B. Alsoussi; Alem Haile; Michael K. Klebert; Teresa Suessen; Luis Parra-Rodriguez; Philip A. Mudd; Sean P. J. Whelan; William D. Middleton; Sharlene A. Teefey; Iskra Pusic; Jane A. O’Halloran; Rachel M. Presti; Jackson S. Turner; Ali H. Ellebedy
Palabras clave: Multidisciplinary.
Pp. 141-145
Genetic instability from a single S phase after whole-genome duplication
Simon Gemble; René Wardenaar; Kristina Keuper; Nishit Srivastava; Maddalena Nano; Anne-Sophie Macé; Andréa E. Tijhuis; Sara Vanessa Bernhard; Diana C. J. Spierings; Anthony Simon; Oumou Goundiam; Helfrid Hochegger; Matthieu Piel; Floris Foijer; Zuzana Storchová; Renata Basto
<jats:title>Abstract</jats:title><jats:p>Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications—doublings of the entire complement of chromosomes—are linked to genetic instability and frequently found in human cancers<jats:sup>1–3</jats:sup>. It has been established that whole-genome duplications fuel chromosome instability through abnormal mitosis<jats:sup>4–8</jats:sup>; however, the immediate consequences of tetraploidy in the first interphase are not known. This is a key question because single whole-genome duplication events such as cytokinesis failure can promote tumorigenesis<jats:sup>9</jats:sup> and DNA double-strand breaks<jats:sup>10</jats:sup>. Here we find that human cells undergo high rates of DNA damage during DNA replication in the first S phase following induction of tetraploidy. Using DNA combing and single-cell sequencing, we show that DNA replication dynamics is perturbed, generating under- and over-replicated regions. Mechanistically, we find that these defects result from a shortage of proteins during the G1/S transition, which impairs the fidelity of DNA replication. This work shows that within a single interphase, unscheduled tetraploid cells can acquire highly abnormal karyotypes. These findings provide an explanation for the genetic instability landscape that favours tumorigenesis after tetraploidization.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 146-151
Crucial role and mechanism of transcription-coupled DNA repair in bacteria
Binod K. Bharati; Manjunath Gowder; Fangfang Zheng; Khaled Alzoubi; Vladimir Svetlov; Venu Kamarthapu; Jacob W. Weaver; Vitaly Epshtein; Nikita Vasilyev; Liqiang Shen; Yu Zhang; Evgeny Nudler
Palabras clave: Multidisciplinary.
Pp. 152-159
Targeting Xist with compounds that disrupt RNA structure and X inactivation
Rodrigo Aguilar; Kerrie B. Spencer; Barry Kesner; Noreen F. Rizvi; Maulik D. Badmalia; Tyler Mrozowich; Jonathan D. Mortison; Carlos Rivera; Graham F. Smith; Julja Burchard; Peter J. Dandliker; Trushar R. Patel; Elliott B. Nickbarg; Jeannie T. Lee
Palabras clave: Multidisciplinary.
Pp. 160-166
Rixosomal RNA degradation contributes to silencing of Polycomb target genes
Haining Zhou; Chad B. Stein; Tiasha A. Shafiq; Gergana Shipkovenska; Marian Kalocsay; Joao A. Paulo; Jiuchun Zhang; Zhenhua Luo; Steven P. Gygi; Karen Adelman; Danesh Moazed
<jats:title>Abstract</jats:title><jats:p>Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) are histone-modifying and -binding complexes that mediate the formation of facultative heterochromatin and are required for silencing of developmental genes and maintenance of cell fate<jats:sup>1–3</jats:sup>. Multiple pathways of RNA decay work together to establish and maintain heterochromatin in fission yeast, including a recently identified role for a conserved RNA-degradation complex known as the rixosome or RIX1 complex<jats:sup>4–6</jats:sup>. Whether RNA degradation also has a role in the stability of mammalian heterochromatin remains unknown. Here we show that the rixosome contributes to silencing of many Polycomb targets in human cells. The rixosome associates with human PRC complexes and is enriched at promoters of Polycomb target genes. Depletion of either the rixosome or Polycomb results in accumulation of paused and elongating RNA polymerase at Polycomb target genes. We identify point mutations in the RING1B subunit of PRC1 that disrupt the interaction between PRC1 and the rixosome and result in diminished silencing, suggesting that direct recruitment of the rixosome to chromatin is required for silencing. Finally, we show that the RNA endonuclease and kinase activities of the rixosome and the downstream XRN2 exoribonuclease, which degrades RNAs with 5′ monophosphate groups generated by the rixosome, are required for silencing. Our findings suggest that rixosomal degradation of nascent RNA is conserved from fission yeast to human, with a primary role in RNA degradation at facultative heterochromatin in human cells.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 167-174