Catálogo de publicaciones - revistas

Compartir en
redes sociales

Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad

Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde jul. 2012 / hasta dic. 2023	Nature.com
No detectada	desde jul. 2006 / hasta ago. 2012	Ovid

Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

Tabla de contenidos

Verificá que desde tu institución tengas acceso para descargar o solicitar el libro completo o alguno de sus capítulos.

doi: 10.1038/s41586-021-04221-8

Anatomically distinct fibroblast subsets determine skin autoimmune patterns

Zijian Xu; Daoming Chen; Yucheng Hu; Kaiju Jiang; Huanwei Huang; Yingxue Du; Wenbo Wu; Jiawen Wang; Jianhua Sui; Wenhui Wang; Long Zhang; Shuli Li; Chunying Li; Yong Yang; Jianmin Chang; Ting Chen

Palabras clave: Multidisciplinary.

Pp. 118-124

doi: 10.1038/s41586-021-04206-7

Non-genetic determinants of malignant clonal fitness at single-cell resolution

Katie A. Fennell; Dane Vassiliadis; Enid Y. N. Lam; Luciano G. Martelotto; Jesse J. Balic; Sebastian Hollizeck; Tom S. Weber; Timothy Semple; Qing Wang; Denise C. Miles; Laura MacPherson; Yih-Chih Chan; Andrew A. Guirguis; Lev M. Kats; Emily S. Wong; Sarah-Jane Dawson; Shalin H. Naik; Mark A. Dawson

Palabras clave: Multidisciplinary.

Pp. 125-131

doi: 10.1038/s41586-021-04204-9

ER proteins decipher the tubulin code to regulate organelle distribution

Pengli Zheng; Christopher J. Obara; Ewa Szczesna; Jonathon Nixon-Abell; Kishore K. Mahalingan; Antonina Roll-Mecak; Jennifer Lippincott-Schwartz; Craig Blackstone

<jats:title>Abstract</jats:title><jats:p>Organelles move along differentially modified microtubules to establish and maintain their proper distributions and functions<jats:sup>1,2</jats:sup>. However, how cells interpret these post-translational microtubule modification codes to selectively regulate organelle positioning remains largely unknown. The endoplasmic reticulumÂ (ER) is an interconnected network of diverse morphologies that extends promiscuously throughout the cytoplasm<jats:sup>3</jats:sup>, forming abundant contacts with other organelles<jats:sup>4</jats:sup>. Dysregulation of endoplasmic reticulum morphology is tightly linked to neurologic disorders and cancer<jats:sup>5,6</jats:sup>. Here we demonstrate that three membrane-bound endoplasmic reticulum proteins preferentially interact with different microtubule populations, with CLIMP63 binding centrosome microtubules, kinectin (KTN1) binding perinuclear polyglutamylated microtubules, and p180 binding glutamylated microtubules. Knockout of these proteins or manipulation of microtubule populations and glutamylation status results in marked changes in endoplasmic reticulum positioning, leading to similar redistributions of other organelles. During nutrient starvation, cells modulate CLIMP63 protein levels and p180â€“microtubule binding to bidirectionally move endoplasmic reticulum and lysosomes for proper autophagic responses.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 132-138