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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Crystallization of bosonic quantum Hall states in a rotating quantum gas
Biswaroop Mukherjee; Airlia Shaffer; Parth B. Patel; Zhenjie Yan; Cedric C. Wilson; Valentin Crépel; Richard J. Fletcher; Martin Zwierlein
Palabras clave: Multidisciplinary.
Pp. 58-62
Drop-in fuels from sunlight and air
Remo Schäppi; David Rutz; Fabian Dähler; Alexander Muroyama; Philipp Haueter; Johan Lilliestam; Anthony Patt; Philipp Furler; Aldo Steinfeld
Palabras clave: Multidisciplinary.
Pp. 63-68
Depressed 660-km discontinuity caused by akimotoite–bridgmanite transition
Artem Chanyshev; Takayuki Ishii; Dmitry Bondar; Shrikant Bhat; Eun Jeong Kim; Robert Farla; Keisuke Nishida; Zhaodong Liu; Lin Wang; Ayano Nakajima; Bingmin Yan; Hu Tang; Zhen Chen; Yuji Higo; Yoshinori Tange; Tomoo Katsura
<jats:title>Abstract</jats:title><jats:p>The 660-kilometre seismic discontinuity is the boundary between the Earth’s lower mantle and transition zone and is commonly interpreted as being due to the dissociation of ringwoodite to bridgmanite plus ferropericlase (post-spinel transition)<jats:sup>1–3</jats:sup>. A distinct feature of the 660-kilometre discontinuity is its depression to 750 kilometres beneath subduction zones<jats:sup>4–10</jats:sup>. However, in situ X-ray diffraction studies using multi-anvil techniques have demonstrated negative but gentle Clapeyron slopes (that is,  the ratio between pressure and temperature changes) of the post-spinel transition that do not allow a significant depression<jats:sup>11–13</jats:sup>. On the other hand, conventional high-pressure experiments face difficulties in accurate phase identification due to inevitable pressure changes during heating and the persistent presence of metastable phases<jats:sup>1,3</jats:sup>. Here we determine the post-spinel and akimotoite–bridgmanite transition boundaries by multi-anvil experiments using in situ X-ray diffraction, with the boundaries strictly based on the definition of phase equilibrium. The post-spinel boundary has almost no temperature dependence, whereas the akimotoite–bridgmanite transition has a very steep negative boundary slope at temperatures lower than ambient mantle geotherms. The large depressions of the 660-kilometre discontinuity in cold subduction zones are thus interpreted as the akimotoite–bridgmanite transition. The steep negative boundary of the akimotoite–bridgmanite transition will cause slab stagnation (a stalling of the slab’s descent) due to significant upward buoyancy<jats:sup>14,15</jats:sup>.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 69-73
Experimental evidence for recovery of mercury-contaminated fish populations
Paul J. Blanchfield; John W. M. Rudd; Lee E. Hrenchuk; Marc Amyot; Christopher L. Babiarz; Ken G. Beaty; R. A. Drew Bodaly; Brian A. Branfireun; Cynthia C. Gilmour; Jennifer A. Graydon; Britt D. Hall; Reed C. Harris; Andrew Heyes; Holger Hintelmann; James P. Hurley; Carol A. Kelly; David P. Krabbenhoft; Steve E. Lindberg; Robert P. Mason; Michael J. Paterson; Cheryl L. Podemski; Ken A. Sandilands; George R. Southworth; Vincent L. St Louis; Lori S. Tate; Michael T. Tate
<jats:title>Abstract</jats:title><jats:p>Anthropogenic releases of mercury (Hg)<jats:sup>1–3</jats:sup> are a human health issue<jats:sup>4</jats:sup> because the potent toxicant methylmercury (MeHg), formed primarily by microbial methylation of inorganic Hg in aquatic ecosystems, bioaccumulates to high concentrations in fish consumed by humans<jats:sup>5,6</jats:sup>. Predicting the efficacy of Hg pollution controls on fish MeHg concentrations is complex because many factors influence the production and bioaccumulation of MeHg<jats:sup>7–9</jats:sup>. Here we conducted a 15-year whole-ecosystem, single-factor experiment to determine the magnitude and timing of reductions in fish MeHg concentrations following reductions in Hg additions to a boreal lake and its watershed. During the seven-year addition phase, we applied enriched Hg isotopes to increase local Hg wet deposition rates fivefold. The Hg isotopes became increasingly incorporated into the food web as MeHg, predominantly from additions to the lake because most of those in the watershed remained there. Thereafter, isotopic additions were stopped, resulting in an approximately 100% reduction in Hg loading to the lake. The concentration of labelled MeHg quickly decreased by up to 91% in lower trophic level organisms, initiating rapid decreases of 38–76% of MeHg concentration in large-bodied fish populations in eight years. Although Hg loading from watersheds may not decline in step with lowering deposition rates, this experiment clearly demonstrates that any reduction in Hg loadings to lakes, whether from direct deposition or runoff, will have immediate benefits to fish consumers.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 74-78
Cyclic evolution of phytoplankton forced by changes in tropical seasonality
Luc Beaufort; Clara T. Bolton; Anta-Clarisse Sarr; Baptiste Suchéras-Marx; Yair Rosenthal; Yannick Donnadieu; Nicolas Barbarin; Samantha Bova; Pauline Cornuault; Yves Gally; Emmeline Gray; Jean-Charles Mazur; Martin Tetard
Palabras clave: Multidisciplinary.
Pp. 79-84
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
Tongtong Zhao; Zachary D. Chiang; Julia W. Morriss; Lindsay M. LaFave; Evan M. Murray; Isabella Del Priore; Kevin Meli; Caleb A. Lareau; Naeem M. Nadaf; Jilong Li; Andrew S. Earl; Evan Z. Macosko; Tyler Jacks; Jason D. Buenrostro; Fei Chen
Palabras clave: Multidisciplinary.
Pp. 85-91
Building an allocentric travelling direction signal via vector computation
Cheng Lyu; L. F. Abbott; Gaby Maimon
Palabras clave: Multidisciplinary.
Pp. 92-97
Transforming representations of movement from body- to world-centric space
Jenny Lu; Amir H. Behbahani; Lydia Hamburg; Elena A. Westeinde; Paul M. Dawson; Cheng Lyu; Gaby Maimon; Michael H. Dickinson; Shaul Druckmann; Rachel I. Wilson
Palabras clave: Multidisciplinary.
Pp. 98-104
Local circuit amplification of spatial selectivity in the hippocampus
Tristan Geiller; Sadra Sadeh; Sebastian V. Rolotti; Heike Blockus; Bert Vancura; Adrian Negrean; Andrew J. Murray; Balázs Rózsa; Franck Polleux; Claudia Clopath; Attila Losonczy
Palabras clave: Multidisciplinary.
Pp. 105-109
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2
Leo Swadling; Mariana O. Diniz; Nathalie M. Schmidt; Oliver E. Amin; Aneesh Chandran; Emily Shaw; Corinna Pade; Joseph M. Gibbons; Nina Le Bert; Anthony T. Tan; Anna Jeffery-Smith; Cedric C. S. Tan; Christine Y. L. Tham; Stephanie Kucykowicz; Gloryanne Aidoo-Micah; Joshua Rosenheim; Jessica Davies; Marina Johnson; Melanie P. Jensen; George Joy; Laura E. McCoy; Ana M. Valdes; Benjamin M. Chain; David Goldblatt; Daniel M. Altmann; Rosemary J. Boyton; Charlotte Manisty; Thomas A. Treibel; James C. Moon; Hakam Abbass; Aderonke Abiodun; Mashael Alfarih; Zoe Alldis; Mervyn Andiapen; Jessica Artico; João B. Augusto; Georgina L. Baca; Sasha N. L. Bailey; Anish N. Bhuva; Alex Boulter; Ruth Bowles; Rosemary J. Boyton; Olivia V. Bracken; Ben O’Brien; Tim Brooks; Natalie Bullock; David K. Butler; Gabriella Captur; Nicola Champion; Carmen Chan; David Collier; Jorge Couto de Sousa; Xose Couto-Parada; Teresa Cutino-Mogue; Rhodri H. Davies; Brooke Douglas; Cecilia Di Genova; Keenan Dieobi-Anene; Anaya Ellis; Karen Feehan; Malcolm Finlay; Marianna Fontana; Nasim Forooghi; Celia Gaier; Derek Gilroy; Matt Hamblin; Gabrielle Harker; Jacqueline Hewson; Lauren M. Hickling; Aroon D. Hingorani; Lee Howes; Alun Hughes; Gemma Hughes; Rebecca Hughes; Ivie Itua; Victor Jardim; Wing-Yiu Jason Lee; Melanie Petra Jensen; Jessica Jones; Meleri Jones; George Joy; Vikas Kapil; Hibba Kurdi; Jonathan Lambourne; Kai-Min Lin; Sarah Louth; Vineela Mandadapu; Áine McKnight; Katia Menacho; Celina Mfuko; Oliver Mitchelmore; Christopher Moon; Diana Munoz-Sandoval; Sam M. Murray; Mahdad Noursadeghi; Ashley Otter; Susana Palma; Ruth Parker; Kush Patel; Babita Pawarova; Steffen E. Petersen; Brian Piniera; Franziska P. Pieper; Daniel Pope; Mary Prossora; Lisa Rannigan; Alicja Rapala; Catherine J. Reynolds; Amy Richards; Matthew Robathan; Genine Sambile; Amanda Semper; Andreas Seraphim; Mihaela Simion; Angelique Smit; Michelle Sugimoto; Stephen Taylor; Nigel Temperton; Stephen Thomas; George D. Thornton; Art Tucker; Jessry Veerapen; Mohit Vijayakumar; Sophie Welch; Theresa Wodehouse; Lucinda Wynne; Dan Zahedi; Lucy van Dorp; Francois Balloux; Áine McKnight; Mahdad Noursadeghi; Antonio Bertoletti; Mala K. Maini;
<jats:title>Abstract</jats:title><jats:p>Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute to the rapid clearance of SARS-CoV-2 and other coronavirus infections<jats:sup>1–3</jats:sup>. Here we hypothesize that pre-existing memory T cell responses, with cross-protective potential against SARS-CoV-2 (refs. <jats:sup>4–11</jats:sup>), would expand in vivo to support rapid viral control, aborting infection. We measured SARS-CoV-2-reactive T cells, including those against the early transcribed replication–transcription complex (RTC)<jats:sup>12,13</jats:sup>, in intensively monitored healthcare workers (HCWs) who tested repeatedly negative according to PCR, antibody binding and neutralization assays (seronegative HCWs (SN-HCWs)). SN-HCWs had stronger, more multispecific memory T cells compared with a cohort of unexposed individuals from before the pandemic (prepandemic cohort), and these cells were more frequently directed against the RTC than the structural-protein-dominated responses observed after detectable infection (matched concurrent cohort). SN-HCWs with the strongest RTC-specific T cells had an increase in <jats:italic>IFI27</jats:italic>, a robust early innate signature of SARS-CoV-2 (ref. <jats:sup>14</jats:sup>), suggesting abortive infection. RNA polymerase within RTC was the largest region of high sequence conservation across human seasonal coronaviruses (HCoV) and SARS-CoV-2 clades. RNA polymerase was preferentially targeted (among the regions tested) by T cells from prepandemic cohorts and SN-HCWs. RTC-epitope-specific T cells that cross-recognized HCoV variants were identified in SN-HCWs. Enriched pre-existing RNA-polymerase-specific T cells expanded in vivo to preferentially accumulate in the memory response after putative abortive compared to overt SARS-CoV-2 infection. Our data highlight RTC-specific T cells as targets for vaccines against endemic and emerging <jats:italic>Coronaviridae</jats:italic>.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 110-117