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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

Palabras clave – provistas por la editorial

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No detectada	desde jul. 2012 / hasta dic. 2023	Nature.com
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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

Tabla de contenidos

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doi: 10.1038/s41586-021-03827-2

Dietary fructose improves intestinal cell survival and nutrient absorption

Samuel R. Taylor; Shakti Ramsamooj; Roger J. Liang; Alyna Katti; Rita Pozovskiy; Neil Vasan; Seo-Kyoung Hwang; Navid Nahiyaan; Nancy J. Francoeur; Emma M. Schatoff; Jared L. Johnson; Manish A. Shah; Andrew J. Dannenberg; Robert P. Sebra; Lukas E. Dow; Lewis C. Cantley; Kyu Y. Rhee; Marcus D. Goncalves

Palabras clave: Multidisciplinary.

Pp. 263-267

doi: 10.1038/s41586-021-03841-4

Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine

Valerie Oberhardt; Hendrik Luxenburger; Janine Kemming; Isabel Schulien; Kevin Ciminski; Sebastian Giese; Benedikt Csernalabics; Julia Lang-Meli; Iga Janowska; Julian Staniek; Katharina Wild; Kristi Basho; Mircea Stefan Marinescu; Jonas Fuchs; Fernando Topfstedt; Ales Janda; Oezlem Sogukpinar; Hanna Hilger; Katarina Stete; Florian Emmerich; Bertram Bengsch; Cornelius F. Waller; Siegbert Rieg; Sagar; Tobias Boettler; Katharina Zoldan; Georg Kochs; Martin Schwemmle; Marta Rizzi; Robert Thimme; Christoph Neumann-Haefelin; Maike Hofmann

<jats:title>Abstract</jats:title><jats:p>SARS-CoV-2 spike mRNA vaccines<jats:sup>1â€“3</jats:sup> mediate protection from severe disease as early as ten days after prime vaccination<jats:sup>3</jats:sup>, when neutralizing antibodies are hardly detectable<jats:sup>4â€“6</jats:sup>. Vaccine-induced CD8<jats:sup>+</jats:sup> T cells may therefore be the main mediators of protection at this early stage<jats:sup>7,8</jats:sup>. The details of their induction, comparison to natural infection, and association with other arms of vaccine-induced immunity remain, however, incompletely understood. Here we show on a single-epitope level that a stable and fully functional CD8<jats:sup>+</jats:sup> T cell response is vigorously mobilized one week after prime vaccination withÂ bnt162b2, when circulating CD4<jats:sup>+</jats:sup> T cells and neutralizing antibodies are still weakly detectable. Boost vaccination induced a robust expansion that generated highly differentiated effector CD8<jats:sup>+</jats:sup> T cells; however, neither the functional capacity nor the memory precursor T cell pool was affected. Compared with natural infection, vaccine-induced early memory T cells exhibited similar functional capacities but a different subset distribution. Our results indicate that CD8<jats:sup>+</jats:sup> T cells are important effector cells, areÂ expanded in the early protection window after prime vaccination, precede maturation of other effector arms of vaccine-induced immunity and are stably maintained after boost vaccination.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 268-273