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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Why are so many young people getting cancer? What the data say
Heidi Ledford
Palabras clave: Multidisciplinary.
Pp. 258-260
US oil and gas system emissions from nearly one million aerial site measurements
Evan D. Sherwin
; Jeffrey S. Rutherford; Zhan Zhang; Yuanlei Chen; Erin B. Wetherley; Petr V. Yakovlev; Elena S. F. Berman; Brian B. Jones; Daniel H. Cusworth; Andrew K. Thorpe; Alana K. Ayasse; Riley M. Duren; Adam R. Brandt
Palabras clave: Multidisciplinary.
Pp. 328-334
Adaptive foraging behaviours in the Horn of Africa during Toba supereruption
John Kappelman; Lawrence C. Todd; Christopher A. Davis; Thure E. Cerling; Mulugeta Feseha; Abebe Getahun; Racheal Johnsen; Marvin Kay; Gary A. Kocurek; Brett A. Nachman; Agazi Negash; Tewabe Negash; Kaedan O’Brien; Michael Pante; Minghua Ren; Eugene I. Smith; Neil J. Tabor; Dereje Tewabe; Hong Wang; Deming Yang; Solomon Yirga; Jordan W. Crowell; Matthew F. Fanuka; Teshager Habtie; Jayde N. Hirniak; Carla Klehm; Natalia D. Loewen; Sahleselasie Melaku; Sierra M. Melton; Timothy S. Myers; Sarah Millonig; Megan C. Plummer; Keenan J. Riordan; Nicholas A. Rosenau; Anne Skinner; Abraham K. Thompson; Lindsey M. Trombetta; Adrienne Witzel; Ephrem Assefa; Maria Bodansky; Ayenachew A. Desta; Christopher J. Campisano; Daniel Dalmas; Connor Elliott; Metasebia Endalamaw; Nicholas J. Ford; Frederick Foster; Tomas Getachew; Yibai Li Haney; Brittney H. Ingram; Jonayah Jackson; Curtis W. Marean; Sissi Mattox; Karla de la Cruz Medina; Gebretsadkan Mulubrhan; Keri Porter; Alexis Roberts; Perla Santillan; Alaric Sollenberger; Julia Sponholtz; Jessica Valdes; Lani Wyman; Meklit Yadeta; Sierra Yanny
Palabras clave: Multidisciplinary.
Pp. No disponible
Benchmarking highly entangled states on a 60-atom analogue quantum simulator
Adam L. Shaw; Zhuo Chen; Joonhee Choi; Daniel K. Mark; Pascal Scholl; Ran Finkelstein; Andreas Elben; Soonwon Choi; Manuel Endres
<jats:title>Abstract</jats:title><jats:p>Quantum systems have entered a competitive regime in which classical computers must make approximations to represent highly entangled quantum states<jats:sup>1,2</jats:sup>. However, in this beyond-classically-exact regime, fidelity comparisons between quantum and classical systems have so far been limited to digital quantum devices<jats:sup>2–5</jats:sup>, and it remains unsolved how to estimate the actual entanglement content of experiments<jats:sup>6</jats:sup>. Here, we perform fidelity benchmarking and mixed-state entanglement estimation with a 60-atom analogue Rydberg quantum simulator, reaching a high-entanglement entropy regime in which exact classical simulation becomes impractical. Our benchmarking protocol involves extrapolation from comparisons against an approximate classical algorithm, introduced here, with varying entanglement limits. We then develop and demonstrate an estimator of the experimental mixed-state entanglement<jats:sup>6</jats:sup>, finding our experiment is competitive with state-of-the-art digital quantum devices performing random circuit evolution<jats:sup>2–5</jats:sup>. Finally, we compare the experimental fidelity against that achieved by various approximate classical algorithms, and find that only the algorithm we introduce is able to keep pace with the experiment on the classical hardware we use. Our results enable a new model for evaluating the ability of both analogue and digital quantum devices to generate entanglement in the beyond-classically-exact regime, and highlight the evolving divide between quantum and classical systems.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Transcription–replication conflicts underlie sensitivity to PARP inhibitors
Michalis Petropoulos; Angeliki Karamichali; Giacomo G. Rossetti; Alena Freudenmann; Luca G. Iacovino; Vasilis S. Dionellis; Sotirios K. Sotiriou; Thanos D. Halazonetis
<jats:title>Abstract</jats:title><jats:p>An important advance in cancer therapy has been the development of poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of homologous recombination (HR)-deficient cancers<jats:sup>1–6</jats:sup>. PARP inhibitors trap PARPs on DNA. The trapped PARPs are thought to block replisome progression, leading to formation of DNA double-strand breaks that require HR for repair<jats:sup>7</jats:sup>. Here we show that PARP1 functions together with TIMELESS and TIPIN to protect the replisome in early S phase from transcription–replication conflicts. Furthermore, the synthetic lethality of PARP inhibitors with HR deficiency is due to an inability to repair DNA damage caused by transcription–replication conflicts, rather than by trapped PARPs. Along these lines, inhibiting transcription elongation in early S phase rendered HR-deficient cells resistant to PARP inhibitors and depleting PARP1 by small-interfering RNA was synthetic lethal with HR deficiency. Thus, inhibiting PARP1 enzymatic activity may suffice for treatment efficacy in HR-deficient settings.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Venous-plexus-associated lymphoid hubs support meningeal humoral immunity
Zachary Fitzpatrick; Nagela Ghabdan Zanluqui; Jared S. Rosenblum; Zewen Kelvin Tuong; Colin Y. C. Lee; Vikram Chandrashekhar; Maria Luciana Negro-Demontel; Andrew P. Stewart; David A. Posner; Monica Buckley; Kieren S. J. Allinson; Panagiotis Mastorakos; Prashant Chittiboina; Dragan Maric; Danielle Donahue; Adel Helmy; Tamara Tajsic; John R. Ferdinand; Anais Portet; Ana Peñalver; Eleanor Gillman; Zhengping Zhuang; Menna R. Clatworthy; Dorian B. McGavern
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Abel Prize for randomness mathematician Michel Talagrand
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
Motor neurons generate pose-targeted movements via proprioceptive sculpting
Benjamin Gorko; Igor Siwanowicz; Kari Close; Christina Christoforou; Karen L. Hibbard; Mayank Kabra; Allen Lee; Jin-Yong Park; Si Ying Li; Alex B. Chen; Shigehiro Namiki; Chenghao Chen; John C. Tuthill; Davi D. Bock; Hervé Rouault; Kristin Branson; Gudrun Ihrke; Stephen J. Huston
Palabras clave: Multidisciplinary.
Pp. No disponible
Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA deficiency
Emmanuel Martin; Sarah Winter; Cécile Garcin; Kay Tanita; Akihiro Hoshino; Christelle Lenoir; Benjamin Fournier; Mélanie Migaud; David Boutboul; Mathieu Simonin; Alicia Fernandes; Paul Bastard; Tom Le Voyer; Anne-Laure Roupie; Yassine Ben Ahmed; Marianne Leruez-Ville; Marianne Burgard; Geetha Rao; Cindy S. Ma; Cécile Masson; Claire Soudais; Capucine Picard; Jacinta Bustamante; Stuart G. Tangye; Nathalie Cheikh; Mikko Seppänen; Anne Puel; Mark Daly; Jean-Laurent Casanova; Bénédicte Neven; Alain Fischer; Sylvain Latour
Palabras clave: Multidisciplinary.
Pp. No disponible
Birds convey complex signals in simple songs
Kate T. Snyder; Nicole Creanza
Palabras clave: Multidisciplinary.
Pp. No disponible