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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
New type of magnetism splits from convention
Carmine Autieri
Palabras clave: Multidisciplinary.
Pp. 482-483
Layered ferroelectric materials make waves — and vortices
Berit H. Goodge
Palabras clave: Multidisciplinary.
Pp. 488-489
Observation of plaid-like spin splitting in a noncoplanar antiferromagnet
Yu-Peng Zhu; Xiaobing Chen; Xiang-Rui Liu; Yuntian Liu; Pengfei Liu; Heming Zha; Gexing Qu; Caiyun Hong; Jiayu Li; Zhicheng Jiang; Xiao-Ming Ma; Yu-Jie Hao; Ming-Yuan Zhu; Wenjing Liu; Meng Zeng; Sreehari Jayaram; Malik Lenger; Jianyang Ding; Shu Mo; Kiyohisa Tanaka; Masashi Arita; Zhengtai Liu; Mao Ye; Dawei Shen; Jörg Wrachtrup; Yaobo Huang; Rui-Hua He; Shan Qiao; Qihang Liu; Chang Liu
Palabras clave: Multidisciplinary.
Pp. 523-528
Drug-resistant microbes: ‘brain drain’ is derailing the fight to stop them
Lilly Tozer
Palabras clave: Multidisciplinary.
Pp. No disponible
Why reciprocity is common in humans but rare in other animals
Sarah Mathew
Palabras clave: Multidisciplinary.
Pp. No disponible
Prevalence of persistent SARS-CoV-2 in a large community surveillance study
Mahan Ghafari; Matthew Hall; Tanya Golubchik; Daniel Ayoubkhani; Thomas House; George MacIntyre-Cockett; Helen R. Fryer; Laura Thomson; Anel Nurtay; Steven A. Kemp; Luca Ferretti; David Buck; Angie Green; Amy Trebes; Paolo Piazza; Lorne J. Lonie; Ruth Studley; Emma Rourke; Darren L. Smith; Matthew Bashton; Andrew Nelson; Matthew Crown; Clare McCann; Gregory R. Young; Rui Andre Nunes dos Santos; Zack Richards; Mohammad Adnan Tariq; Roberto Cahuantzi; Jeff Barrett; Christophe Fraser; David Bonsall; Ann Sarah Walker; Katrina Lythgoe; ; ;
<jats:title>Abstract</jats:title><jats:p>Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future outbreaks<jats:sup>1–5</jats:sup>, give rise to highly divergent lineages<jats:sup>6–8</jats:sup> and contribute to cases with post-acute COVID-19 sequelae (long COVID)<jats:sup>9,10</jats:sup>. However, the population prevalence of persistent infections, their viral load kinetics and evolutionary dynamics over the course of infections remain largely unknown. Here, using viral sequence data collected as part of a national infection survey, we identified 381 individuals with SARS-CoV-2 RNA at high titre persisting for at least 30 days, of which 54 had viral RNA persisting at least 60 days. We refer to these as ‘persistent infections’ as available evidence suggests that they represent ongoing viral replication, although the persistence of non-replicating RNA cannot be ruled out in all. Individuals with persistent infection had more than 50% higher odds of self-reporting long COVID than individuals with non-persistent infection. We estimate that 0.1–0.5% of infections may become persistent with typically rebounding high viral loads and last for at least 60 days. In some individuals, we identified many viral amino acid substitutions, indicating periods of strong positive selection, whereas others had no consensus change in the sequences for prolonged periods, consistent with weak selection. Substitutions included mutations that are lineage defining for SARS-CoV-2 variants, at target sites for monoclonal antibodies and/or are commonly found in immunocompromised people<jats:sup>11–14</jats:sup>. This work has profound implications for understanding and characterizing SARS-CoV-2 infection, epidemiology and evolution.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4
Ali Maisam Afzali; Lucy Nirschl; Christopher Sie; Monika Pfaller; Oleksii Ulianov; Tobias Hassler; Christine Federle; Elisabetta Petrozziello; Sudhakar Reddy Kalluri; Hsin Hsiang Chen; Sofia Tyystjärvi; Andreas Muschaweckh; Katja Lammens; Claire Delbridge; Andreas Büttner; Katja Steiger; Gönül Seyhan; Ole Petter Ottersen; Rupert Öllinger; Roland Rad; Sebastian Jarosch; Adrian Straub; Anton Mühlbauer; Simon Grassmann; Bernhard Hemmer; Jan P. Böttcher; Ingrid Wagner; Mario Kreutzfeldt; Doron Merkler; Irene Bonafonte Pardàs; Marc Schmidt Supprian; Veit R. Buchholz; Sylvia Heink; Dirk H. Busch; Ludger Klein; Thomas Korn
<jats:title>Abstract</jats:title><jats:p>Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen<jats:sup>1</jats:sup>. The immunopathology in neuromyelitis optica is largely driven by autoantibodies to AQP4<jats:sup>2</jats:sup>. However, the T cell response that is required for the generation of these anti-AQP4 antibodies is not well understood. Here we show that B cells endogenously express AQP4 in response to activation with anti-CD40 and IL-21 and are able to present their endogenous AQP4 to T cells with an AQP4-specific T cell receptor (TCR). A population of thymic B cells emulates a CD40-stimulated B cell transcriptome, including AQP4 (in mice and humans), and efficiently purges the thymic TCR repertoire of AQP4-reactive clones. Genetic ablation of <jats:italic>Aqp4</jats:italic> in B cells rescues AQP4-specific TCRs despite sufficient expression of AQP4 in medullary thymic epithelial cells, and B-cell-conditional AQP4-deficient mice are fully competent to raise AQP4-specific antibodies in productive germinal-centre responses. Thus, the negative selection of AQP4-specific thymocytes is dependent on the expression and presentation of AQP4 by thymic B cells. As AQP4 is expressed in B cells in a CD40-dependent (but not AIRE-dependent) manner, we propose that thymic B cells might tolerize against a group of germinal-centre-associated antigens, including disease-relevant autoantigens such as AQP4.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Evolutionary novelties underlie sound production in baleen whales
Coen P. H. Elemans; Weili Jiang; Mikkel H. Jensen; Helena Pichler; Bo R. Mussman; Jacob Nattestad; Magnus Wahlberg; Xudong Zheng; Qian Xue; W. Tecumseh Fitch
Palabras clave: Multidisciplinary.
Pp. No disponible
An innovative way for whales to sing
Joy S. Reidenberg
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Great ‘Stone Age’ wall discovered in Baltic Sea
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible