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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

Palabras clave – provistas por la editorial

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No detectada	desde jul. 2012 / hasta dic. 2023	Nature.com
No detectada	desde jul. 2006 / hasta ago. 2012	Ovid

Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

Tabla de contenidos

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doi: 10.1038/d41586-024-00232-3

Smoking’s lasting effect on the immune system

Yang Luo; Simon Stent

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-024-00420-1

Largest post-pandemic survey finds trust in scientists is high

Carissa Wong

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/s41586-024-07069-w

A single-cell time-lapse of mouse prenatal development from gastrula to birth

Chengxiang Qiu; Beth K. Martin; Ian C. Welsh; Riza M. Daza; Truc-Mai Le; Xingfan Huang; Eva K. Nichols; Megan L. Taylor; Olivia Fulton; Diana R. O’Day; Anne Roshella Gomes; Saskia Ilcisin; Sanjay Srivatsan; Xinxian Deng; Christine M. Disteche; William Stafford Noble; Nobuhiko Hamazaki; Cecilia B. Moens; David Kimelman; Junyue Cao; Alexander F. Schier; Malte Spielmann; Stephen A. Murray; Cole Trapnell; Jay Shendure

<jats:title>Abstract</jats:title><jats:p>The house mouse (<jats:italic>Mus musculus</jats:italic>) is an exceptional model system, combining genetic tractability with close evolutionary affinity to humans<jats:sup>1,2</jats:sup>. Mouse gestation lasts only 3 weeks, during which the genome orchestrates the astonishing transformation of a single-cell zygote into a free-living pup composed of more than 500 million cells. Here, to establish a global framework for exploring mammalian development, we applied optimized single-cell combinatorial indexing<jats:sup>3</jats:sup> to profile the transcriptional states of 12.4 million nuclei from 83 embryos, precisely staged at 2- to 6-hour intervals spanning late gastrulation (embryonic day 8) to birth (postnatal day 0). From these data, we annotate hundreds of cell types and explore the ontogenesis of the posterior embryo during somitogenesis and of kidney, mesenchyme, retina and early neurons. We leverage the temporal resolution and sampling depth of these whole-embryo snapshots, together with published data<jats:sup>4–8</jats:sup> from earlier timepoints, to construct a rooted tree of cell-type relationships that spans the entirety of prenatal development, from zygote to birth. Throughout this tree, we systematically nominate genes encoding transcription factors and other proteins as candidate drivers of the in vivo differentiation of hundreds of cell types. Remarkably, the most marked temporal shifts in cell states are observed within one hour of birth and presumably underlie the massive physiological adaptations that must accompany the successful transition of a mammalian fetus to life outside the womb.</jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible