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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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No detectada	desde jul. 2012 / hasta dic. 2023	Nature.com
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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

Tabla de contenidos

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doi: 10.1038/s41586-022-05021-4

Scalable single-mode surface-emitting laser via open-Dirac singularities

Rushin Contractor; Wanwoo Noh; Walid Redjem; Wayesh Qarony; Emma Martin; Scott Dhuey; Adam Schwartzberg; Boubacar Kanté

Palabras clave: Multidisciplinary.

Pp. 692-698

doi: 10.1038/s41586-022-05004-5

Mechanical integrated circuit materials

Charles El Helou; Benjamin Grossmann; Christopher E. Tabor; Philip R. Buskohl; Ryan L. Harne

Palabras clave: Multidisciplinary.

Pp. 699-703

doi: 10.1038/s41586-022-04983-9

Fast-charging aluminiumâ€“chalcogen batteries resistant to dendritic shorting

Quanquan Pang; Jiashen Meng; Saransh Gupta; Xufeng Hong; Chun Yuen Kwok; Ji Zhao; Yingxia Jin; Like Xu; Ozlem Karahan; Ziqi Wang; Spencer Toll; Liqiang Mai; Linda F. Nazar; Mahalingam Balasubramanian; Badri Narayanan; Donald R. Sadoway

Palabras clave: Multidisciplinary.

Pp. 704-711

doi: 10.1038/s41586-022-05029-w

Microporous water with high gas solubilities

Daniel P. Erdosy; Malia B. Wenny; Joy Cho; Christopher DelRe; Miranda V. Walter; Felipe Jiménez-Ángeles; Baofu Qiao; Ricardo Sanchez; Yifeng Peng; Brian D. Polizzotti; Monica Olvera de la Cruz; Jarad A. Mason

Palabras clave: Multidisciplinary.

Pp. 712-718

doi: 10.1038/s41586-022-04968-8

Integrated ozone depletion as a metric for ozone recovery

John A. Pyle; James Keeble; Nathan Luke Abraham; Martyn P. Chipperfield; Paul T. Griffiths

Palabras clave: Multidisciplinary.

Pp. 719-723

doi: 10.1038/s41586-022-05072-7

Diverse mutational landscapes in human lymphocytes

Heather E. Machado; Emily Mitchell; Nina F. Øbro; Kirsten Kübler; Megan Davies; Daniel Leongamornlert; Alyssa Cull; Francesco Maura; Mathijs A. Sanders; Alex T. J. Cagan; Craig McDonald; Miriam Belmonte; Mairi S. Shepherd; Felipe A. Vieira Braga; Robert J. Osborne; Krishnaa Mahbubani; Iñigo Martincorena; Elisa Laurenti; Anthony R. Green; Gad Getz; Paz Polak; Kourosh Saeb-Parsy; Daniel J. Hodson; David G. Kent; Peter J. Campbell

<jats:title>Abstract</jats:title><jats:p>The lymphocyte genome is prone to many threats, including programmed mutation during differentiation<jats:sup>1</jats:sup>, antigen-driven proliferation and residency in diverse microenvironments. Here, after developing protocols for expansion of single-cell lymphocyte cultures, we sequenced whole genomes from 717 normal naive and memory B and T cells and haematopoietic stem cells. All lymphocyte subsets carried more point mutations and structural variants than haematopoietic stem cells, with higher burdens in memory cells than in naive cells, and with T cells accumulating mutations at a higher rate throughout life. Off-target effects of immunological diversification accounted for approximately half of the additional differentiation-associated mutations in lymphocytes. Memory B cells acquired, on average, 18 off-target mutations genome-wide for every on-target <jats:italic>IGHV</jats:italic> mutation during the germinal centre reaction. Structural variation was 16-fold higher in lymphocytes than in stem cells, with around 15% of deletions being attributable to off-target recombinase-activating gene activity. DNA damage from ultraviolet light exposure and other sporadic mutational processes generated hundreds to thousands of mutations in some memory cells. The mutation burden and signatures of normal B cells were broadly similar to those seen in many B-cell cancers, suggesting that malignant transformation of lymphocytes arises from the same mutational processes that are active across normal ontogeny. The mutational landscape of normal lymphocytes chronicles the off-target effects of programmed genome engineering during immunological diversification and the consequences of differentiation, proliferation and residency in diverse microenvironments.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 724-732

Accedé al texto completo

doi: 10.1038/s41586-022-05046-9

Live-seq enables temporal transcriptomic recording of single cells

Wanze Chen; Orane Guillaume-Gentil; Pernille Yde Rainer; Christoph G. Gäbelein; Wouter Saelens; Vincent Gardeux; Amanda Klaeger; Riccardo Dainese; Magda Zachara; Tomaso Zambelli; Julia A. Vorholt; Bart Deplancke

<jats:title>Abstract</jats:title><jats:p>Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize cellular heterogeneity<jats:sup>1</jats:sup>. However, scRNA-seq requires lysing cells, which impedes further molecular or functional analyses on the same cells. Here, we established Live-seq, a single-cell transcriptome profiling approach that preserves cell viability during RNA extraction using fluidic force microscopy<jats:sup>2,3</jats:sup>, thus allowing to couple a cellâ€™s ground-state transcriptome to its downstream molecular or phenotypic behaviour. To benchmark Live-seq, we used cell growth, functional responses and whole-cell transcriptome read-outs to demonstrate that Live-seq can accurately stratify diverse cell types and states without inducing major cellular perturbations. As a proof of concept, we show that Live-seq can be used to directly map a cellâ€™s trajectory by sequentially profiling the transcriptomes of individual macrophages before and after lipopolysaccharide (LPS) stimulation, and of adipose stromal cells pre- and post-differentiation. In addition, we demonstrate that Live-seq can function as a transcriptomic recorder by preregistering the transcriptomes of individual macrophages that were subsequently monitored by time-lapse imaging after LPS exposure. This enabled the unsupervised, genome-wide ranking of genes on the basis of their ability to affect macrophage LPS response heterogeneity, revealing basal <jats:italic>Nfkbia</jats:italic> expression level and cell cycle state as important phenotypic determinants, which we experimentally validated. Thus, Live-seq can address a broad range of biological questions by transforming scRNA-seq from an end-point to a temporal analysis approach.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 733-740