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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
What Japan’s election means for controversial defence research
Smriti Mallapaty
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Monarch butterflies are an endangered species
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
Electroreduction of nitrogen at almost 100% current-to-ammonia efficiency
Hoang-Long Du
; Manjunath Chatti; Rebecca Y. Hodgetts; Pavel V. Cherepanov; Cuong K. Nguyen; Karolina Matuszek; Douglas R. MacFarlane; Alexandr N. Simonov
Palabras clave: Multidisciplinary.
Pp. No disponible
It’s time to make science in remote places family-friendly
Melissa Ward Jones; Mette Bendixen
Palabras clave: Multidisciplinary.
Pp. No disponible
Monkeypox declared a global emergency: will it help contain the outbreaks?
Max Kozlov
Palabras clave: Multidisciplinary.
Pp. No disponible
Disco-ball satellite will put Einstein’s theory to strictest test yet
Davide Castelvecchi
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Why smells bring back such specific memories
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Congo Basin could be auctioned off to big oil
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
China approves first homegrown COVID antiviral
Yvaine Ye
Palabras clave: Multidisciplinary.
Pp. No disponible
Discovery, structure and mechanism of a tetraether lipid synthase
Cody T. Lloyd; David F. Iwig; Bo Wang; Matteo Cossu; William W. Metcalf; Amie K. Boal; Squire J. Booker
<jats:title>Abstract</jats:title><jats:p>Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to withstand extreme environmental conditions, such as high temperatures, high salinity, and low or high pH values<jats:sup>1–5</jats:sup>. In some archaea, such as <jats:italic>Methanocaldococcus jannaschii</jats:italic>, these lipids are further modified by forming carbon–carbon bonds between the termini of two lipid tails within one glycerophospholipid to generate the macrocyclic archaeol or forming two carbon–carbon bonds between the termini of two lipid tails from two glycerophospholipids to generate the macrocycle glycerol dibiphytanyl glycerol tetraether (GDGT)<jats:sup>1,2</jats:sup>. GDGT contains two 40-carbon lipid chains (biphytanyl chains) that span both leaflets of the membrane, providing enhanced stability to extreme conditions. How these specialized lipids are formed has puzzled scientists for decades. The reaction necessitates the coupling of two completely inert sp<jats:sup>3</jats:sup>-hybridized carbon centres, which, to our knowledge, has not been observed in nature. Here we show that the gene product of <jats:italic>mj0619</jats:italic> from <jats:italic>M. jannaschii</jats:italic>, which encodes a radical <jats:italic>S</jats:italic>-adenosylmethionine enzyme, is responsible for biphytanyl chain formation during synthesis of both the macrocyclic archaeol and GDGT membrane lipids<jats:sup>6</jats:sup>. Structures of the enzyme show the presence of four metallocofactors: three [Fe<jats:sub>4</jats:sub>S<jats:sub>4</jats:sub>] clusters and one mononuclear rubredoxin-like iron ion. In vitro mechanistic studies show that Csp<jats:sup>3</jats:sup>–Csp<jats:sup>3</jats:sup> bond formation takes place on fully saturated archaeal lipid substrates and involves an intermediate bond between the substrate carbon and a sulfur of one of the [Fe<jats:sub>4</jats:sub>S<jats:sub>4</jats:sub>] clusters. Our results not only establish the biosynthetic route for tetraether formation but also improve the use of GDGT in GDGT-based paleoclimatology indices<jats:sup>7–10</jats:sup>.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible