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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

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doi: 10.1038/s41586-022-04747-5

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Ambre M. Bertholet; Andrew M. Natale; Paola Bisignano; Junji Suzuki; Andriy Fedorenko; James Hamilton; Tatiana Brustovetsky; Lawrence Kazak; Ryan Garrity; Edward T. Chouchani; Nickolay Brustovetsky; Michael Grabe; Yuriy Kirichok

Palabras clave: Multidisciplinary.

Pp. 180-187

doi: 10.1038/s41586-022-04727-9

Gibbin mesodermal regulation patterns epithelial development

Ann Collier; Angela Liu; Jessica Torkelson; Jillian Pattison; Sadhana Gaddam; Hanson Zhen; Tiffany Patel; Kelly McCarthy; Hana Ghanim; Anthony E. Oro

Palabras clave: Multidisciplinary.

Pp. 188-196

doi: 10.1038/s41586-022-04730-0

MCM complexes are barriers that restrict cohesin-mediated loop extrusion

Bart J. H. Dequeker; Matthias J. Scherr; Hugo B. Brandão; Johanna Gassler; Sean Powell; Imre Gaspar; Ilya M. Flyamer; Aleksandar Lalic; Wen Tang; Roman Stocsits; Iain F. Davidson; Jan-Michael Peters; Karl E. Duderstadt; Leonid A. Mirny; Kikuë Tachibana

<jats:title>Abstract</jats:title><jats:p>Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)<jats:sup>1â€“3</jats:sup>, which contribute to transcription, recombination and genomic stability<jats:sup>4,5</jats:sup>. Cohesin extrudes DNA into loops that are thought to lengthen until CTCF boundaries are encountered<jats:sup>6â€“12</jats:sup>. Little is known about whether loop extrusion is impeded by DNA-bound machines. Here we show that the minichromosome maintenance (MCM) complex is a barrier that restricts loop extrusion in G1 phase. Single-nucleus Hi-C (high-resolution chromosome conformation capture) of mouse zygotes reveals that MCM loading reduces CTCF-anchored loops and decreases TAD boundary insulation, which suggests that loop extrusion is impeded before reaching CTCF. This effect extends to HCT116 cells, in which MCMs affect the number of CTCF-anchored loops and gene expression. Simulations suggest that MCMs are abundant, randomly positioned and partially permeable barriers. Single-molecule imaging shows that MCMs are physical barriers that frequently constrain cohesin translocation in vitro. Notably, chimeric yeast MCMs that contain a cohesin-interaction motif from human MCM3 induce cohesin pausing, indicating that MCMs are â€˜activeâ€™ barriers with binding sites. These findings raise the possibility that cohesin can arrive by loop extrusion at MCMs, which determine the genomic sites at which sister chromatid cohesion is established. On the basis of in vivo, in silico and in vitro data, we conclude that distinct loop extrusion barriers shape the three-dimensional genome.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 197-203