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Now we come to the most important aspect of all. Can the new findings lead to formulation of innovative treatments to alter the course of, or possibly even eradicate, the disease?

I went on to do a study on pathological features of atheroma lesions in a group of patients who had received an anti- antibiotic for at least 6 months duration. The aim was to determine the effect of antibiotics on eradication of the germ and parameters of healing to the lesion [].

Antibiotic studies have been done on experimental animals. There are, however, differences in the pathological features of such lesions compared to humans, and such treatment has been of short duration. Because of this, there has been some criticism of these type of studies. Nevertheless, there were some beneficial effects with the use of the antibiotics azithromycin and clarithromycin. For example, there are studies showing that, in animal models, early treatment with azithromycin prevents development of atherosclerosis lesions, or results in decrease in the size of the lesion. Although antibiotic treatment blunts or eliminates the atherosclerotic response in animals, direct immunofluorescence reveals persistence of antigens, and culture-negative DNA is frequently recovered after treatment. These findings question whether complete eradication of the germ occurs with this type of treatment.

While treatment of heart attack patients has provided some information on the effect of treatment on the clinical outcome, it has not provided sufficient information on the effect of antibiotics on the atherosclerosis lesion per se. There are too many factors involved in causing heart attacks to really specifically pinpoint the exact effect and target of the treatment to the underlying atherosclerotic lesion.

There are an increasing number of articles showing that existing drugs may have beneficial effects on the atheroma lesion.

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